JPS55100376A - Novel analogue of prostacycline and its manufacture - Google Patents

Novel analogue of prostacycline and its manufacture

Info

Publication number: JPS55100376A
Authority: JP; Japan
Prior art keywords: prostacycline; manufacture; preparation; action; novel analogue
Prior art date: 1979-01-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP769280A

Other languages

English (en)

Inventor

Barutoman Buiruherumu

Kontsu Erumaru

Reruhi Ururitsuhi

Shierukensu Berunbuaruto

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee

Hoechst AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-01-25

Filing date

1980-01-25

Publication date

1980-07-31

1980-01-25 Application filed by Hoechst AG filed Critical Hoechst AG

1980-07-31 Publication of JPS55100376A publication Critical patent/JPS55100376A/ja

Status Pending legal-status Critical Current

Links

KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical class O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
KAQKFAOMNZTLHT-OZUDYXHBSA-N prostaglandin I2 Chemical compound O1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-OZUDYXHBSA-N 0.000 abstract 2
101000862089 Clarkia lewisii Glucose-6-phosphate isomerase, cytosolic 1A Proteins 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
238000004220 aggregation Methods 0.000 abstract 1
210000001772 blood platelet Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
210000004351 coronary vessel Anatomy 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229960001123 epoprostenol Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003815 prostacyclins Chemical class 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Paints Or Removers (AREA)
Furan Compounds (AREA)

JP769280A 1979-01-25 1980-01-25 Novel analogue of prostacycline and its manufacture Pending JPS55100376A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19792902809 DE2902809A1 (de)	1979-01-25	1979-01-25	Neue analoga von prostacyclin

Publications (1)

Publication Number	Publication Date
JPS55100376A true JPS55100376A (en)	1980-07-31

Family

ID=6061363

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP769280A Pending JPS55100376A (en)	1979-01-25	1980-01-25	Novel analogue of prostacycline and its manufacture

Country Status (11)

Country	Link
US (1)	US4312882A (ja)
EP (1)	EP0013955B1 (ja)
JP (1)	JPS55100376A (ja)
AT (1)	ATE3640T1 (ja)
AU (1)	AU539763B2 (ja)
CA (1)	CA1207761A (ja)
DE (2)	DE2902809A1 (ja)
ES (1)	ES487818A0 (ja)
HU (1)	HU184767B (ja)
IL (1)	IL59209A (ja)
ZA (1)	ZA80441B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3029984C2 (de) *	1980-08-08	1983-12-15	Grünenthal GmbH, 5190 Stolberg	2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel
DE3107100A1 (de) *	1981-02-20	1982-09-09	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Azaprostacycline, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE3147714A1 (de) *	1981-11-27	1983-06-01	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue prostacycline und verfahren zu ihrer herstellung
JPS6130554A (ja) *	1984-07-23	1986-02-12	Ono Pharmaceut Co Ltd	プロスタグランジン類似化合物のある特定の立体配置を有する異性体及びそれらを有効成分として含有する治療剤
US5221689A (en) *	1984-07-23	1993-06-22	Ono Pharmaceutical Co., Ltd.	Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them
CN107129495B (zh) *	2017-05-18	2019-04-19	厦门大学	一种毒扁豆碱前体化合物的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS53103464A (en) *	1977-02-21	1978-09-08	Ono Pharmaceut Co Ltd	Prostaglandin x analogues and process for their preparation
JPS53116365A (en) *	1977-03-22	1978-10-11	Ono Pharmaceut Co Ltd	Prostaglandin x analogous compounds and process for their preparation
JPS5481259A (en) *	1977-11-25	1979-06-28	Erba Carlo Spa	155epiiprostacycline*analogue prostacyclines and their manufacture
JPS54115368A (en) *	1978-03-01	1979-09-07	Ono Pharmaceut Co Ltd	Prostaglandin i2 analog, its preparation, and drug composition containing it as active constituent
JPS54115367A (en) *	1978-03-01	1979-09-07	Ono Pharmaceut Co Ltd	Prostaglandin i2 analog, its preparation, and drug composition containing it as active constituent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2351112A1 (fr) *	1975-10-21	1977-12-09	Wellcome Found	Derive de prostaglandine et medicament contenant ce derive
US4158667A (en) *	1976-02-04	1979-06-19	The Upjohn Company	6-Keto PGF analogs
US4178367A (en) *	1977-02-21	1979-12-11	Ono Pharmaceutical Co. Ltd.	Prostaglandin I2 analogues
HU182583B (en) *	1977-03-01	1984-02-28	Chinoin Gyogyszer Es Vegyeszet	Process for preparing prostacyclin and analogues thereof
AU524786B2 (en) *	1977-03-07	1982-10-07	The Upjohn Company	Prostacyclins
JPS53136513A (en)	1977-05-06	1978-11-29	Ono Pharmaceut Co Ltd	Stabilization of prostaglandin-x-related compounds
DE2753244A1 (de) *	1977-11-25	1979-06-07	Schering Ag	Neue prostacyclinderivate und verfahren zu ihrer herstellung

1979
- 1979-01-25 DE DE19792902809 patent/DE2902809A1/de not_active Withdrawn
1980
- 1980-01-18 ES ES487818A patent/ES487818A0/es active Granted
- 1980-01-21 AT AT80100262T patent/ATE3640T1/de not_active IP Right Cessation
- 1980-01-21 DE DE8080100262T patent/DE3063556D1/de not_active Expired
- 1980-01-21 EP EP80100262A patent/EP0013955B1/de not_active Expired
- 1980-01-23 US US06/114,684 patent/US4312882A/en not_active Expired - Lifetime
- 1980-01-23 IL IL59209A patent/IL59209A/xx unknown
- 1980-01-24 ZA ZA00800441A patent/ZA80441B/xx unknown
- 1980-01-24 HU HU80146A patent/HU184767B/hu unknown
- 1980-01-24 CA CA000344316A patent/CA1207761A/en not_active Expired
- 1980-01-24 AU AU54902/80A patent/AU539763B2/en not_active Ceased
- 1980-01-25 JP JP769280A patent/JPS55100376A/ja active Pending

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS53103464A (en) *	1977-02-21	1978-09-08	Ono Pharmaceut Co Ltd	Prostaglandin x analogues and process for their preparation
JPS53116365A (en) *	1977-03-22	1978-10-11	Ono Pharmaceut Co Ltd	Prostaglandin x analogous compounds and process for their preparation
JPS5481259A (en) *	1977-11-25	1979-06-28	Erba Carlo Spa	155epiiprostacycline*analogue prostacyclines and their manufacture
JPS54115368A (en) *	1978-03-01	1979-09-07	Ono Pharmaceut Co Ltd	Prostaglandin i2 analog, its preparation, and drug composition containing it as active constituent
JPS54115367A (en) *	1978-03-01	1979-09-07	Ono Pharmaceut Co Ltd	Prostaglandin i2 analog, its preparation, and drug composition containing it as active constituent

Also Published As

Publication number	Publication date
AU5490280A (en)	1980-07-31
US4312882A (en)	1982-01-26
DE3063556D1 (en)	1983-07-07
EP0013955A1 (de)	1980-08-06
HU184767B (en)	1984-10-29
ES8102563A1 (es)	1981-01-16
EP0013955B1 (de)	1983-06-01
DE2902809A1 (de)	1980-08-07
AU539763B2 (en)	1984-10-18
ATE3640T1 (de)	1983-06-15
ES487818A0 (es)	1981-01-16
CA1207761A (en)	1986-07-15
IL59209A0 (en)	1980-05-30
ZA80441B (en)	1981-01-28
IL59209A (en)	1987-10-30

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