JPS55111469A - Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient - Google Patents

Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient

Info

Publication number
JPS55111469A
JPS55111469A JP1721879A JP1721879A JPS55111469A JP S55111469 A JPS55111469 A JP S55111469A JP 1721879 A JP1721879 A JP 1721879A JP 1721879 A JP1721879 A JP 1721879A JP S55111469 A JPS55111469 A JP S55111469A
Authority
JP
Japan
Prior art keywords
formula
preparation
active ingredient
antitumor drug
geldanamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1721879A
Other languages
Japanese (ja)
Other versions
JPS6334866B2 (en
Inventor
Kazuya Sasaki
Yukio Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Kaken Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd, Kaken Chemical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Priority to JP1721879A priority Critical patent/JPS55111469A/en
Priority to US06/109,314 priority patent/US4261989A/en
Priority to AU54430/80A priority patent/AU532333B2/en
Priority to GB8001321A priority patent/GB2042523B/en
Priority to FR8002589A priority patent/FR2449084A1/en
Priority to NL8000857A priority patent/NL8000857A/en
Priority to CA345,489A priority patent/CA1113935A/en
Priority to DE19803006097 priority patent/DE3006097A1/en
Priority to IT20017/80A priority patent/IT1147315B/en
Publication of JPS55111469A publication Critical patent/JPS55111469A/en
Publication of JPS6334866B2 publication Critical patent/JPS6334866B2/ja
Granted legal-status Critical Current

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  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The title compound shown by the formula I (one of R1 and R2 is H, the other is 2≤C saturated alkyl, unsaturated alkyl, substituted lower alkyl, cycloalkyl, aralkyl; R1 and R2 form alkylene together).
EXAMPLE: 17-n-Propylamino geldanamycin
USE: A synthetic intermediate for an antitumor agent, a drug for a veterinarian, or other derivative. A daily dose for an adult is 0.5W80mg/kg in the case of nonoral administration and 1W100mg/kg in the case of oral administration.
PROCESS: A geldanamycin shown by the formula II is reacted with an amine, e.g. n-propylamine, ehtyleneimine, shown by the formula III preferably in the presence of an organic solvent, e.g., chloroform at room temperature to give the desired compound shown by the formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP1721879A 1979-02-19 1979-02-19 Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient Granted JPS55111469A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP1721879A JPS55111469A (en) 1979-02-19 1979-02-19 Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient
US06/109,314 US4261989A (en) 1979-02-19 1980-01-03 Geldanamycin derivatives and antitumor drug
AU54430/80A AU532333B2 (en) 1979-02-19 1980-01-08 Geldanamycin derivatives
GB8001321A GB2042523B (en) 1979-02-19 1980-01-15 Geldanamycin derivatives and anti-tumor drug
FR8002589A FR2449084A1 (en) 1979-02-19 1980-02-06 NOVEL GELDANAMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
NL8000857A NL8000857A (en) 1979-02-19 1980-02-12 MONEY ANAMYCIN DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE AS A MEDICINAL PRODUCT.
CA345,489A CA1113935A (en) 1979-02-19 1980-02-13 Geldanamycin derivatives and antitumor drug
DE19803006097 DE3006097A1 (en) 1979-02-19 1980-02-19 MONEY AMININE DERIVATIVES AND ANTITUARY MEDICINES WITH THE SAME
IT20017/80A IT1147315B (en) 1979-02-19 1980-02-19 GELDANAMYCIN DERIVATIVES AND ANTI-CANCER DRUGS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1721879A JPS55111469A (en) 1979-02-19 1979-02-19 Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient

Publications (2)

Publication Number Publication Date
JPS55111469A true JPS55111469A (en) 1980-08-28
JPS6334866B2 JPS6334866B2 (en) 1988-07-12

Family

ID=11937794

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1721879A Granted JPS55111469A (en) 1979-02-19 1979-02-19 Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient

Country Status (1)

Country Link
JP (1) JPS55111469A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55111419A (en) * 1979-02-20 1980-08-28 Kaken Pharmaceut Co Ltd Antitumorigenic agent
JP2002520369A (en) * 1998-07-17 2002-07-09 アメリカ合衆国 Water-soluble drug and method for producing the same
JP2002532535A (en) * 1998-12-22 2002-10-02 アメリカ合衆国 Water-insoluble drug delivery system
JP2002541255A (en) * 1999-04-09 2002-12-03 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Methods and compositions for degrading and / or inhibiting HER family tyrosine kinases
US6890917B2 (en) 2001-03-30 2005-05-10 The United States Of America As Represented By The Department Of Health And Human Services Geldanamycin derivative and method of treating cancer using same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55111419A (en) * 1979-02-20 1980-08-28 Kaken Pharmaceut Co Ltd Antitumorigenic agent
JP2002520369A (en) * 1998-07-17 2002-07-09 アメリカ合衆国 Water-soluble drug and method for producing the same
JP2002532535A (en) * 1998-12-22 2002-10-02 アメリカ合衆国 Water-insoluble drug delivery system
JP2002541255A (en) * 1999-04-09 2002-12-03 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Methods and compositions for degrading and / or inhibiting HER family tyrosine kinases
US6890917B2 (en) 2001-03-30 2005-05-10 The United States Of America As Represented By The Department Of Health And Human Services Geldanamycin derivative and method of treating cancer using same

Also Published As

Publication number Publication date
JPS6334866B2 (en) 1988-07-12

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