JPS5519217A - Aminophenyl ether derivative and its preparation - Google Patents
Aminophenyl ether derivative and its preparationInfo
- Publication number
- JPS5519217A JPS5519217A JP9129278A JP9129278A JPS5519217A JP S5519217 A JPS5519217 A JP S5519217A JP 9129278 A JP9129278 A JP 9129278A JP 9129278 A JP9129278 A JP 9129278A JP S5519217 A JPS5519217 A JP S5519217A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- cis
- aryl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GOJFAKBEASOYNM-UHFFFAOYSA-N 2-(2-aminophenoxy)aniline Chemical class NC1=CC=CC=C1OC1=CC=CC=C1N GOJFAKBEASOYNM-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- HVXJILXIZHJUAE-UHFFFAOYSA-N 1-[4-[2-(4-methylcyclohexyl)propan-2-yloxy]phenyl]piperidine Chemical compound C1CC(C)CCC1C(C)(C)OC1=CC=C(N2CCCCC2)C=C1 HVXJILXIZHJUAE-UHFFFAOYSA-N 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 102000015779 HDL Lipoproteins Human genes 0.000 abstract 1
- 108010010234 HDL Lipoproteins Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:Aminophenyl ether derivatives of formula I [R is H, halogen, alkyl; R1 is H, alkyl; R2 is cyclohexyl; R3 is H, alkyl, phenyl; R4 is H, alkyl, aryl; R5 is H, aryl, -COR6, -CH2R6 (R6 is H, alkyl, cyclohexyl, aryl): where R2 and R2 may incorporate to form cyclohexane; R4 and R5 may combine to form pyrrolidine or piperidine ring].
EXAMPLE: cis-1-[4-(P-menthane-8-yloxy)phenyl]piperidine.
USE: Anticholesteremic; they have activities of lowering cholesterol and triglyceride and increasing selectively high-density lipoprotein in blood.
PREPARATION: For example, the cis- or trans-isomer of an alcohol of formula II is reacted with a compound of formula III (X is halogen) in the presence of a strong base and the product is reduced to give the cis- or trans-isomer of the compound of formula I (R4, R5 are H).
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9129278A JPS5519217A (en) | 1978-07-26 | 1978-07-26 | Aminophenyl ether derivative and its preparation |
| GB8124879A GB2086377B (en) | 1977-12-29 | 1978-12-15 | Cyclic aminophenyl ether compounds |
| GB7848658A GB2011888B (en) | 1977-12-29 | 1978-12-15 | Aminophenyl ether compoungd |
| CA318,098A CA1110248A (en) | 1977-12-29 | 1978-12-18 | Method of producing aminophenyl ether compound |
| DE19782854595 DE2854595A1 (en) | 1977-12-29 | 1978-12-18 | AMINOPHENYL ETHER COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND USE |
| FR7836263A FR2413382A1 (en) | 1977-12-29 | 1978-12-22 | AMINOPHENYL ETHER COMPOUNDS USED FOR THE TREATMENT OF ARTERIOSCLEROSIS |
| NL7812574A NL7812574A (en) | 1977-12-29 | 1978-12-27 | AMINOPHENYL ETHERS COMPOUNDS, METHODS FOR PREPARING THEM, AND PHARMACEUTICAL PREPARATIONS. |
| DK584978A DK584978A (en) | 1977-12-29 | 1978-12-28 | METHOD OF MAKING AMINOPHENYLETHERE |
| NO784394A NO784394L (en) | 1977-12-29 | 1978-12-28 | PROCEDURES FOR THE PREPARATION OF AMINOPHENYL ETHER COMPOUNDS |
| SE7813355A SE7813355L (en) | 1977-12-29 | 1978-12-28 | AMINOPHENYLETHER ASSOCIATIONS |
| IT7869973A IT7869973A0 (en) | 1977-12-29 | 1978-12-28 | AMINOPHENYL ETHERS PARTICULARLY USEFUL IN THERAPY AND PROCEDURE FOR THEIR PREPARATION |
| ES476458A ES476458A1 (en) | 1977-12-29 | 1978-12-28 | Aminophenyl Ether Compounds |
| AU43017/78A AU4301778A (en) | 1977-12-29 | 1978-12-29 | Aminophenyl ether compounds |
| AT0935778A AT367738B (en) | 1977-12-29 | 1978-12-29 | METHOD FOR PRODUCING NEW AMINOPHENYL ETHER COMPOUNDS AND THEIR SALTS |
| ES481504A ES481504A1 (en) | 1977-12-29 | 1979-06-12 | Aminophenyl Ether Compounds |
| ES481505A ES481505A1 (en) | 1977-12-29 | 1979-06-12 | Aminophenyl Ether Compounds |
| CA356,441A CA1110246A (en) | 1977-12-29 | 1980-07-17 | Method of producing cyclic-aminophenyl ether compound |
| FR8016962A FR2457863A1 (en) | 1977-12-29 | 1980-07-31 | AMINOPHENYL ETHER COMPOUNDS FOR THE TREATMENT OF ARTERIOSCLEROSIS |
| NO820355A NO820355L (en) | 1977-12-29 | 1982-02-05 | PROCEDURES FOR THE PREPARATION OF CYCLIC AMINOPHENYL ETHER COMPOUNDS. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9129278A JPS5519217A (en) | 1978-07-26 | 1978-07-26 | Aminophenyl ether derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5519217A true JPS5519217A (en) | 1980-02-09 |
Family
ID=14022381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9129278A Pending JPS5519217A (en) | 1977-12-29 | 1978-07-26 | Aminophenyl ether derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5519217A (en) |
-
1978
- 1978-07-26 JP JP9129278A patent/JPS5519217A/en active Pending
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