JPS5522657A - Reactive compound - Google Patents
Reactive compoundInfo
- Publication number
- JPS5522657A JPS5522657A JP16491178A JP16491178A JPS5522657A JP S5522657 A JPS5522657 A JP S5522657A JP 16491178 A JP16491178 A JP 16491178A JP 16491178 A JP16491178 A JP 16491178A JP S5522657 A JPS5522657 A JP S5522657A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- bioactive substance
- group
- reactive
- equimolor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 230000000975 bioactive effect Effects 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 108010093096 Immobilized Enzymes Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- -1 hapten Substances 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:A reactive compound of formula I (R is benzothiazolyl, 2- pyridyl-N-oxide; X1 is a spacer; X2 is bonding group; A is residue of bioactive substance).
EXAMPLE: A reactive compound of insulin wherein the amino group of the 29- position lysine of the B-chain is bonded to 3-(benzothiazol-2'-yldithio)propionyl group through an amide linkage.
USE: A compound useful for enzymatic immunoassay, solid component of immobilized enzyme, immunizing component, etc.
PROCESS: A compound II is reacted with nearly equimolor amount of a compound III (X3 is a group reactive with a bioactive substance) in an inert solvent such as benzene, at 10W70°C to afford the compound IV, which is made to react with nearly equimolor amount of a bioactive substance (e.g. hapten, antigen, etc.) in an inert solvent such as acetone, to afford the objective compound I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16491178A JPS5522657A (en) | 1978-12-28 | 1978-12-28 | Reactive compound |
| FR7918007A FR2430943A1 (en) | 1978-07-13 | 1979-07-11 | NEW DISULFIDE DERIVATIVES |
| GB7924336A GB2029825B (en) | 1978-07-13 | 1979-07-12 | Benzothiazolyl and pyndyl n oxide disulphide derivatives |
| DE19792928384 DE2928384A1 (en) | 1978-07-13 | 1979-07-13 | DISULFID DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16491178A JPS5522657A (en) | 1978-12-28 | 1978-12-28 | Reactive compound |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53085900A Division JPS6058232B2 (en) | 1978-07-13 | 1978-07-13 | Novel disulfide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5522657A true JPS5522657A (en) | 1980-02-18 |
Family
ID=15802196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16491178A Pending JPS5522657A (en) | 1978-07-13 | 1978-12-28 | Reactive compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5522657A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58500480A (en) * | 1981-04-06 | 1983-03-31 | フア−マシア・アクチエボラ−グ | therapeutically active compounds |
-
1978
- 1978-12-28 JP JP16491178A patent/JPS5522657A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58500480A (en) * | 1981-04-06 | 1983-03-31 | フア−マシア・アクチエボラ−グ | therapeutically active compounds |
| US5124441A (en) * | 1981-04-06 | 1992-06-23 | Pharmacia Aktiebolag | Therapeutically active compound and its use |
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