JPS5526878A - Enzyme activating plasminogen and its preparation - Google Patents

Enzyme activating plasminogen and its preparation

Info

Publication number
JPS5526878A
JPS5526878A JP10037378A JP10037378A JPS5526878A JP S5526878 A JPS5526878 A JP S5526878A JP 10037378 A JP10037378 A JP 10037378A JP 10037378 A JP10037378 A JP 10037378A JP S5526878 A JPS5526878 A JP S5526878A
Authority
JP
Japan
Prior art keywords
dextran sulfate
enzyme
urokinase
room temperature
ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10037378A
Other languages
Japanese (ja)
Inventor
Akira Murakami
Shigeo Yoshizaki
Masao Oguchi
Toshito Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP10037378A priority Critical patent/JPS5526878A/en
Publication of JPS5526878A publication Critical patent/JPS5526878A/en
Pending legal-status Critical Current

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  • Enzymes And Modification Thereof (AREA)

Abstract

PURPOSE: To provide an enzyme activating plasminogen with stabilized activity (such as resistance to heat treatment, stability during transportation, or during freeze drying process) by combining specific substances.
CONSTITUTION: Urokinase and dextran sulfate of 1,000W20,000 molecular weight (instrinsic viscosity of 0.030W0.040, sulfur content of 3W6%) are combined at a ratio of 1:10W10:1 to form covalent bonds, thus giving said enzyme. The enzyme is obtained by effecting reaction between dextran sulfate and cyan halide under alkaline conditions (0.1W5 times amount, based on the dextran sulfate, of cyanogen halide is used at a pH of 8W13.0 and 0°C W room temperature), followed by acting urokinase on the activated dextran sulfate at a ratio of 1:10W10:1 urokinase to dextran sulfate at 0°C W room temperature under weak alkali conditions for 1W30hr.
COPYRIGHT: (C)1980,JPO&Japio
JP10037378A 1978-08-17 1978-08-17 Enzyme activating plasminogen and its preparation Pending JPS5526878A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10037378A JPS5526878A (en) 1978-08-17 1978-08-17 Enzyme activating plasminogen and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10037378A JPS5526878A (en) 1978-08-17 1978-08-17 Enzyme activating plasminogen and its preparation

Publications (1)

Publication Number Publication Date
JPS5526878A true JPS5526878A (en) 1980-02-26

Family

ID=14272225

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10037378A Pending JPS5526878A (en) 1978-08-17 1978-08-17 Enzyme activating plasminogen and its preparation

Country Status (1)

Country Link
JP (1) JPS5526878A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6141674U (en) * 1984-08-23 1986-03-17 ジャガー株式会社 Full-rotation hook of sewing machine
JPH07132085A (en) * 1980-04-03 1995-05-23 Abbott Lab Method for producing plasminogen activator protein

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07132085A (en) * 1980-04-03 1995-05-23 Abbott Lab Method for producing plasminogen activator protein
JPS6141674U (en) * 1984-08-23 1986-03-17 ジャガー株式会社 Full-rotation hook of sewing machine

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