JPS55348A - Antibiotic of cephalosporin analogue - Google Patents
Antibiotic of cephalosporin analogueInfo
- Publication number
- JPS55348A JPS55348A JP15803078A JP15803078A JPS55348A JP S55348 A JPS55348 A JP S55348A JP 15803078 A JP15803078 A JP 15803078A JP 15803078 A JP15803078 A JP 15803078A JP S55348 A JPS55348 A JP S55348A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- thienyl
- alpha
- compound
- cephalosporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Compounds of formula I (Ar is 2-thienyl, 3-thienyl, phenyl, p-alkanoyloxyphenyl, etc.; B<1> and B<2> are H, alkyl, aralkyl, aryl) or their salts. EXAMPLE:7beta-[alpha-Carboxy-alpha-(3-thienyl)acetamide]-7alpha-methox y-3-(1-methyltetrazole-5-yl)thiomethyl-1-oxadethia-3-cepham-4-carboxylic acid. USE:Antibacterial and bactericidal agent or their synthetic intermediates, being effective on both gram-positive and -negative bacteria and further on bacteria producing beta-lactamase and resisting cephalosporin. PREPARATION:The compound of formula II is made to react with a malonic derivative of formula III or its reactive derivative to produce the compound of formula I. The reaction is carried out in a solvent and, when necessary, a condensation agent, acid acceptor, and an organic base are added.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15803078A JPS55348A (en) | 1978-12-18 | 1978-12-18 | Antibiotic of cephalosporin analogue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15803078A JPS55348A (en) | 1978-12-18 | 1978-12-18 | Antibiotic of cephalosporin analogue |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5029576A Division JPS52133997A (en) | 1976-03-25 | 1976-04-30 | Cephalosporin antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55348A true JPS55348A (en) | 1980-01-05 |
Family
ID=15662730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15803078A Pending JPS55348A (en) | 1978-12-18 | 1978-12-18 | Antibiotic of cephalosporin analogue |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55348A (en) |
-
1978
- 1978-12-18 JP JP15803078A patent/JPS55348A/en active Pending
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