JPS5535009A - New antibiotic sf-1739hp-c and hp-f, their preparation and anticarcinogen having new antibiotic sf-1739hp-c and hp-f as active component - Google Patents
New antibiotic sf-1739hp-c and hp-f, their preparation and anticarcinogen having new antibiotic sf-1739hp-c and hp-f as active componentInfo
- Publication number
- JPS5535009A JPS5535009A JP10749278A JP10749278A JPS5535009A JP S5535009 A JPS5535009 A JP S5535009A JP 10749278 A JP10749278 A JP 10749278A JP 10749278 A JP10749278 A JP 10749278A JP S5535009 A JPS5535009 A JP S5535009A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- new antibiotic
- soluble
- methanol
- treated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 3
- 239000003005 anticarcinogenic agent Substances 0.000 title abstract 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- GATAXMKQDPALOM-QYPOQKIVSA-N antibiotic sf-1739 Chemical compound OC1=C(C)C(=O)C(=O)C([C@H]2CO)=C1[C@@H]1N3CCO[C@H]3[C@@H]3C[C@H]4N(C)[C@@H]3[C@@H]1N2[C@@H]4O GATAXMKQDPALOM-QYPOQKIVSA-N 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000936710 Streptomyces griseoplanus Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003217 anti-cancerogenic effect Effects 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 abstract 1
- 238000000921 elemental analysis Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 238000004809 thin layer chromatography Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
NEW MATERIAL:Antibiotic SF-1739HP-C. Elemental analysis (%): C 59.58, H 6.14, N 12.63, O 21.65 (rest) ; solubility: easily soluble in water and methanol, soluble in acetone and ethyl acetate and slightly soluble in hexane; Rf value of silica gel thin-layer chromatography: 0.40 (chloroform-methanol = 9:1) and 0.70 (ethyl acetate-methnol = 3:2), dark purple spot. Dark purple substance; does not show clear melting point, and gradually tirns to black from about 120W150°C.
USE: Anticarcinogens having low toxicity, and high antifungal and anticarcinogenic properties.
PROCESS: SF-1739HP substance is obtained by cultivating Streptomyces griseoplanus SF-1739 under aerobic conditions and treating the produced SF-1739 substance (Japanes Patent publication No.51-125798) with an acid. The SF-1739HP is treated with a cyanide to obtain SF-1739HP-C. Or the SF-1739HP is treated with formaldehyde to obtain SF-1739HP-F.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10749278A JPS5535009A (en) | 1978-09-04 | 1978-09-04 | New antibiotic sf-1739hp-c and hp-f, their preparation and anticarcinogen having new antibiotic sf-1739hp-c and hp-f as active component |
| GB7903605A GB2017079B (en) | 1978-02-08 | 1979-02-01 | Substance sf-1739 derivatives |
| US06/008,406 US4209509A (en) | 1978-02-08 | 1979-02-01 | Substance SF-1739 derivatives, process for preparing the same and antibacterial compositions containing the same |
| DE2904628A DE2904628C2 (en) | 1978-02-08 | 1979-02-07 | Substance SF-1739 HP-C, a process for its preparation and agents with antibacterial and antitumor effects which contain this substance |
| FR7903149A FR2416899A1 (en) | 1978-02-08 | 1979-02-07 | DERIVATIVES OF SUBSTANCE SF-1739, THEIR PREPARATION AND THEIR THERAPEUTIC USES |
| DE2954282A DE2954282C2 (en) | 1978-02-08 | 1979-02-07 | Substance SF-1739 HP, a process for its preparation, and agents with antibacterial and antitumor effects which contain this substance |
| NLAANVRAGE7904766,A NL186514C (en) | 1978-08-16 | 1979-06-19 | DERIVATIVES OF COMPOUND SF-1739, METHODS FOR THE PREPARATION THEREOF, AND ANTIBACTERIAL AND ANTITUMOR PREPARATIONS CONTAINING THESE COMPOUNDS |
| SE7905693A SE445921B (en) | 1978-08-16 | 1979-06-28 | Derivatives of Substance SF-1739, termed SF-1739 HP-C, PREPARED BY CULTIVATION OF STREPTOMYCES GRISEOPLANUS STEM SF-1739 (ATCC 31451) AND COMPOSITION CONTAINING SUBSTANCE |
| CH606479A CH642667A5 (en) | 1978-08-16 | 1979-06-28 | Derivatives of the substance SF-1739, process for the preparation of such derivatives and antibacterial and cancer-preventing preparations containing such derivatives |
| IT24026/79A IT1121986B (en) | 1978-08-16 | 1979-06-29 | ANTIBACTERIAL AND ANTI-TUMORAL ACTION COMPOUNDS, PROCEDURE FOR MANUFACTURING THEM AND COMPOSITIONS CONTAINING THEM |
| CA330,894A CA1105450A (en) | 1978-08-16 | 1979-06-29 | Substance sf-1739 derivatives, process for preparing the same and antibacterial and antitumor compositions containing the same |
| ES482569A ES482569A0 (en) | 1978-08-16 | 1979-06-29 | PROCEDURE FOR THE MANUFACTURE OF COMPLEX ANTIBIOTIC AND ANTIBACTERIAL ANTIBIOTICS. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10749278A JPS5535009A (en) | 1978-09-04 | 1978-09-04 | New antibiotic sf-1739hp-c and hp-f, their preparation and anticarcinogen having new antibiotic sf-1739hp-c and hp-f as active component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5535009A true JPS5535009A (en) | 1980-03-11 |
| JPS6230197B2 JPS6230197B2 (en) | 1987-07-01 |
Family
ID=14460572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10749278A Granted JPS5535009A (en) | 1978-02-08 | 1978-09-04 | New antibiotic sf-1739hp-c and hp-f, their preparation and anticarcinogen having new antibiotic sf-1739hp-c and hp-f as active component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5535009A (en) |
-
1978
- 1978-09-04 JP JP10749278A patent/JPS5535009A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6230197B2 (en) | 1987-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE39218L (en) | Mycophenolic acid derivatives | |
| IE831360L (en) | Inoculation of seeds with freeze-dried microorganisms | |
| JPS5547630A (en) | Optical resolution of phosphorus-containing amino acid | |
| JPS5535009A (en) | New antibiotic sf-1739hp-c and hp-f, their preparation and anticarcinogen having new antibiotic sf-1739hp-c and hp-f as active component | |
| JPS5557506A (en) | Agricultural and horticultural blight and pest control composition | |
| JPS53121998A (en) | Preparation of maytansiol, maytansine and maytansinol propionate | |
| JPS53111085A (en) | Preparation of phenylpyridazinone derivative | |
| JPS56113799A (en) | Glucoside derivative | |
| JPS5527132A (en) | Novel antibiotic substances sf-1739hp-3 and ph-5, their preparation, and carcinostatic agent containing novel antibiotic substances sf-1739hp-3 and hp-5 as effective components | |
| JPS5529972A (en) | Preparation of maytansinol | |
| JPS5687595A (en) | Novel bioactive substance herbimycin b, its preparation, and agricultural and horticultural agent containing said substance as effective component | |
| JPS5416357A (en) | Looper controller | |
| JPS579776A (en) | Production of anthracycline | |
| JPS5428893A (en) | Preparation of sarcosine oxidase | |
| JPS5639049A (en) | Phenyl acetate, its preparation, insecticide, and acaricide | |
| JPS54105235A (en) | Prophylactics and remedies for hog dysentery | |
| JPS53124692A (en) | Preparation of maytansinol, maytansine, and maytansinol, propionate | |
| JPS5522656A (en) | Preparation of 1alpha,24(s),25-trihydroxycholecalciferol | |
| JPS5579396A (en) | Novel antibiotic, sf-2012-l substance, and its preparation | |
| JPS53113093A (en) | Preparation of physiological active agent p9-12 | |
| JPS5212993A (en) | Method of producing antibiotics | |
| JPS55138395A (en) | Production of 9alpha-hydroxyandrosterone compound by microorganism | |
| JPS5791993A (en) | Novel antibiotic substance, its preparation and microorganism capable of producing the same | |
| JPS57131706A (en) | Fungicidal composition for rice field | |
| JPS56127085A (en) | Treatment of seepage from soil |