JPS5535012A - Compound of epoxysuccinylamino acid - Google Patents

Compound of epoxysuccinylamino acid

Info

Publication number
JPS5535012A
JPS5535012A JP10776678A JP10776678A JPS5535012A JP S5535012 A JPS5535012 A JP S5535012A JP 10776678 A JP10776678 A JP 10776678A JP 10776678 A JP10776678 A JP 10776678A JP S5535012 A JPS5535012 A JP S5535012A
Authority
JP
Japan
Prior art keywords
formula
acid
proteinase
alkylene
activities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10776678A
Other languages
Japanese (ja)
Other versions
JPS6155508B2 (en
Inventor
Jiro Sawada
Kazunori Hanada
Masaharu Tamai
Shigeo Morimoto
Sadafumi Omura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Priority to JP10776678A priority Critical patent/JPS5535012A/en
Publication of JPS5535012A publication Critical patent/JPS5535012A/en
Publication of JPS6155508B2 publication Critical patent/JPS6155508B2/ja
Granted legal-status Critical Current

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  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The title compound (trans-form) of formula I (A is single bond, C1-4 alkylene; B is C1-5 alkylene; R is C3-10 cycloalkyl, C5-8 cycloalkenyl; R<2> is H, OH, phenyl, indolyl, etc.; R<3> is C1-4 alkyl, benzyl, etc.). EXAMPLE:N-( DL-3-cyclopentanepropyloxycarbonyloxirane-2-carbonyl )-L-leucine ethyl ester. USE:Inhibitor which strongly inhibits the activities of proteinase, e.g. papaine, ficin, bromelin, etc. The thiol group is the one exhibiting the activities of proteinase. Extremely low toxic, and no acceleration of blood vessel penetration. PROCESS:For example, an epoxysuccinic acid monoester of formula II (R<5> is H, alkali metal) is converted to the acid chloride with a halogenating agent, e.g. oxalyl chloride. The acid chloride is then treated with an amino acid ester of formula III to give the objective compound of formula I.
JP10776678A 1978-09-02 1978-09-02 Compound of epoxysuccinylamino acid Granted JPS5535012A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10776678A JPS5535012A (en) 1978-09-02 1978-09-02 Compound of epoxysuccinylamino acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10776678A JPS5535012A (en) 1978-09-02 1978-09-02 Compound of epoxysuccinylamino acid

Publications (2)

Publication Number Publication Date
JPS5535012A true JPS5535012A (en) 1980-03-11
JPS6155508B2 JPS6155508B2 (en) 1986-11-28

Family

ID=14467449

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10776678A Granted JPS5535012A (en) 1978-09-02 1978-09-02 Compound of epoxysuccinylamino acid

Country Status (1)

Country Link
JP (1) JPS5535012A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185149A (en) * 1987-03-27 1993-02-09 Merck & Co., Inc. Methods for thrombolytic therapy
US5545672A (en) * 1993-02-11 1996-08-13 The University Of Texas System Treatment of insulin resistance and type 2 diabetes mellitus with a thiol protease inhibitor
WO1999011640A1 (en) * 1997-09-04 1999-03-11 Nippon Chemiphar Co., Ltd. Epoxysuccinamide derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185149A (en) * 1987-03-27 1993-02-09 Merck & Co., Inc. Methods for thrombolytic therapy
US5545672A (en) * 1993-02-11 1996-08-13 The University Of Texas System Treatment of insulin resistance and type 2 diabetes mellitus with a thiol protease inhibitor
WO1999011640A1 (en) * 1997-09-04 1999-03-11 Nippon Chemiphar Co., Ltd. Epoxysuccinamide derivatives

Also Published As

Publication number Publication date
JPS6155508B2 (en) 1986-11-28

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