JPS5559151A - Aminoacid derivative - Google Patents

Aminoacid derivative

Info

Publication number
JPS5559151A
JPS5559151A JP13339378A JP13339378A JPS5559151A JP S5559151 A JPS5559151 A JP S5559151A JP 13339378 A JP13339378 A JP 13339378A JP 13339378 A JP13339378 A JP 13339378A JP S5559151 A JPS5559151 A JP S5559151A
Authority
JP
Japan
Prior art keywords
formula
compound
naphthyl
give
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13339378A
Other languages
Japanese (ja)
Other versions
JPS5827784B2 (en
Inventor
Setsuo Fujii
Mamoru Sugimoto
Takashi Yaegashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii Pharmaceutical Co Ltd
Original Assignee
Torii Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii Pharmaceutical Co Ltd filed Critical Torii Pharmaceutical Co Ltd
Priority to JP13339378A priority Critical patent/JPS5827784B2/en
Priority to GB7937424A priority patent/GB2034718B/en
Priority to DE19792943582 priority patent/DE2943582C2/en
Priority to FR7926782A priority patent/FR2440356A1/en
Publication of JPS5559151A publication Critical patent/JPS5559151A/en
Publication of JPS5827784B2 publication Critical patent/JPS5827784B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/30—Naphthol derivatives, e.g. alpha-naphthyl-esters, i.e. alpha-NE, beta-naphthyl-esters, i.e. beta-NE
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96455—Kallikrein (3.4.21.34; 3.4.21.35)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:Aminoacid derivatives of formula I (R1 is H, benzoyl; R2 is naphthyl, 6-bromo-2-naphthyl).
EXAMPLE: L-prolyl-L-phenylalanyl-L-alginyl-1-naphthyl ester hydrochloride.
USE: Agent for measuring the activity of enzymes as tripsin or Rallikrein.
PREPARATION: A compound of formula II and an alginine derivative of formula III is dissolved in a solvent as chloroform or dimethylformamide, an esterification accelerator as DCC or DPPA is added, and, when necessary, triethylamine is added. They are stirred at 0W40°C to give a compound of formula IV, from which groups protecting amino groups are removed, e.g., by hydrogenation using Pd-C catalyst to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP13339378A 1978-10-30 1978-10-30 amino acid derivative Expired JPS5827784B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP13339378A JPS5827784B2 (en) 1978-10-30 1978-10-30 amino acid derivative
GB7937424A GB2034718B (en) 1978-10-30 1979-10-29 Prolyl-phenylalanylarginine derivatives process for their preparation and their use for measuring enzyme activity
DE19792943582 DE2943582C2 (en) 1978-10-30 1979-10-29 L-prolyl-L-phenylalanyl-L-arginine derivatives, process for their preparation and their use
FR7926782A FR2440356A1 (en) 1978-10-30 1979-10-29 PROLYLPHENYLALANYLARGININ DERIVATIVES, THEIR PREPARATION METHOD, AND THEIR USE FOR MEASURING THE ACTIVITY OF ENZYMES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13339378A JPS5827784B2 (en) 1978-10-30 1978-10-30 amino acid derivative

Publications (2)

Publication Number Publication Date
JPS5559151A true JPS5559151A (en) 1980-05-02
JPS5827784B2 JPS5827784B2 (en) 1983-06-11

Family

ID=15103689

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13339378A Expired JPS5827784B2 (en) 1978-10-30 1978-10-30 amino acid derivative

Country Status (4)

Country Link
JP (1) JPS5827784B2 (en)
DE (1) DE2943582C2 (en)
FR (1) FR2440356A1 (en)
GB (1) GB2034718B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335203A (en) * 1980-07-10 1982-06-15 The Regents Of The University Of California Method for identifying potential contrast media reactors
US4395401A (en) 1981-09-09 1983-07-26 Smithkline Beckman Corporation Renally active dipeptides
US4386075A (en) * 1982-02-17 1983-05-31 Smithkline Beckman Corporation Renally active tetrapeptides
US4387049A (en) * 1982-02-22 1983-06-07 Smithkline Beckman Corporation Adamantyl containing peptides
JPS6117956A (en) * 1984-07-04 1986-01-25 Nitto Boseki Co Ltd Novel substrate for measuring kallikrein in urine
CN114184562B (en) * 2021-11-19 2024-07-26 北京赛升药业股份有限公司 Method for measuring urokinase activity by chromogenic substrate method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2527932C2 (en) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Acid addition salts of tripeptide derivatives and their use as substrates for the determination of plasma kallikrein

Also Published As

Publication number Publication date
FR2440356B1 (en) 1983-11-25
GB2034718A (en) 1980-06-11
JPS5827784B2 (en) 1983-06-11
GB2034718B (en) 1983-01-06
FR2440356A1 (en) 1980-05-30
DE2943582C2 (en) 1982-11-18
DE2943582A1 (en) 1980-05-29

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