JPS5576852A - Novel derivative of anthranilic acid - Google Patents
Novel derivative of anthranilic acidInfo
- Publication number
- JPS5576852A JPS5576852A JP14920078A JP14920078A JPS5576852A JP S5576852 A JPS5576852 A JP S5576852A JP 14920078 A JP14920078 A JP 14920078A JP 14920078 A JP14920078 A JP 14920078A JP S5576852 A JPS5576852 A JP S5576852A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- formula
- acid
- anthranilic acid
- novel derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 title abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- XPMYQNSUVAGTKP-UHFFFAOYSA-N 4-chloro-2-[3-(3,4-dimethoxyphenyl)prop-2-enoylamino]benzoic acid Chemical compound C1=C(OC)C(OC)=CC=C1C=CC(=O)NC1=CC(Cl)=CC=C1C(O)=O XPMYQNSUVAGTKP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical class OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000001976 improved effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
NEW MATERIAL:A derivative of anthranilic acid of formula I (X is halogen; R1 is H or lower alkyl; R2 is benzoyl etc. substituted with 1W3 methoxy groups at arbitrary positions).
EXAMPLE: N-(3,4-Dimethoxycinnamoyl)-4-chloroanthranilic acid.
USE: Drug having an anti-allergic activity and anti-inflammatory activity, improved pharmaceutical activities, and low side effects.
PROCESS: The title derivative of formula I is obtained by the reaction of a derivative of anthranilic acid of formula II with a reactive derivative of aromatic carboxylic acid of formula III (e.g. acid halide.) in an organic solvent, e.g. acetone.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14920078A JPS5576852A (en) | 1978-12-01 | 1978-12-01 | Novel derivative of anthranilic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14920078A JPS5576852A (en) | 1978-12-01 | 1978-12-01 | Novel derivative of anthranilic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5576852A true JPS5576852A (en) | 1980-06-10 |
| JPS6154018B2 JPS6154018B2 (en) | 1986-11-20 |
Family
ID=15470003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14920078A Granted JPS5576852A (en) | 1978-12-01 | 1978-12-01 | Novel derivative of anthranilic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5576852A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0360417A3 (en) * | 1988-08-24 | 1991-10-23 | Schering Agrochemicals Limited | Derivatives of 4-fluoroanthranilic acid and their use as fungicides |
| JP2009541363A (en) * | 2006-07-05 | 2009-11-26 | フィブロテック セラピューティクス プロプライエタリー リミテッド | Therapeutic compounds |
| US8624056B2 (en) | 2007-12-21 | 2014-01-07 | Fibrotech Therapeutics Pty Ltd | Halogenated analogues of anti-fibrotic agents |
| US9951087B2 (en) | 2009-10-22 | 2018-04-24 | Fibrotech Therapeutics Pty Ltd | Fused ring analogues of anti-fibrotic agents |
| US11014873B2 (en) | 2017-02-03 | 2021-05-25 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0634780U (en) * | 1992-10-13 | 1994-05-10 | 古河機械金属株式会社 | Construction vehicle with floor cleaning device |
-
1978
- 1978-12-01 JP JP14920078A patent/JPS5576852A/en active Granted
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0360417A3 (en) * | 1988-08-24 | 1991-10-23 | Schering Agrochemicals Limited | Derivatives of 4-fluoroanthranilic acid and their use as fungicides |
| JP2009541363A (en) * | 2006-07-05 | 2009-11-26 | フィブロテック セラピューティクス プロプライエタリー リミテッド | Therapeutic compounds |
| US8765812B2 (en) | 2006-07-05 | 2014-07-01 | Fibrotech Therapeutics Pty Ltd | Therapeutic compounds |
| US9561201B2 (en) | 2006-07-05 | 2017-02-07 | Fibrotech Therapeutics Pty Ltd | Therapeutic compounds |
| US8624056B2 (en) | 2007-12-21 | 2014-01-07 | Fibrotech Therapeutics Pty Ltd | Halogenated analogues of anti-fibrotic agents |
| US9951087B2 (en) | 2009-10-22 | 2018-04-24 | Fibrotech Therapeutics Pty Ltd | Fused ring analogues of anti-fibrotic agents |
| US11014873B2 (en) | 2017-02-03 | 2021-05-25 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
| US11603349B2 (en) | 2017-02-03 | 2023-03-14 | Certa Therapeutics Pty Ltd | Anti-fibrotic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6154018B2 (en) | 1986-11-20 |
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