JPS5562901A - Preparation of high polymer having thyroliberyl group - Google Patents
Preparation of high polymer having thyroliberyl groupInfo
- Publication number
- JPS5562901A JPS5562901A JP13613578A JP13613578A JPS5562901A JP S5562901 A JPS5562901 A JP S5562901A JP 13613578 A JP13613578 A JP 13613578A JP 13613578 A JP13613578 A JP 13613578A JP S5562901 A JPS5562901 A JP S5562901A
- Authority
- JP
- Japan
- Prior art keywords
- high polymer
- thyroliberyl
- group
- amino group
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 title abstract 6
- 125000003277 amino group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 abstract 2
- 229920000936 Agarose Polymers 0.000 abstract 1
- 239000004952 Polyamide Substances 0.000 abstract 1
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229920002647 polyamide Polymers 0.000 abstract 1
- 229920000570 polyether Polymers 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000001646 thyrotropic effect Effects 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Landscapes
- Polyamides (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
PURPOSE: To obtain the title polymer capable of retaining the secretion promotion action of thyrotropic hormone in vivo for a long time, by reacting a high polymer having at least one amino group with an ω-thyroliberyl-alkanoic acid (derivative).
CONSTITUTION: (A) A natural high polymer, e.g. polysaccharide or protein, a synthetic high polymer, e.g. polyamide, polyvinyl compound, or polyether, such as a condensate of agarose and hexamethylenediamine having at least one amino group, is reacted with (B) about 1W3 equivalents per equivalent of free amino group in (A) of an ω-thyroliberyl-alkanoic acid of formula I: (PCA-His-Pro- is pyroglutamylhistidylprolyl group; n is an integer 1W12) or its reactive derivative to give a high polymer having at least one residue of formula II.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13613578A JPS5562901A (en) | 1978-11-04 | 1978-11-04 | Preparation of high polymer having thyroliberyl group |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13613578A JPS5562901A (en) | 1978-11-04 | 1978-11-04 | Preparation of high polymer having thyroliberyl group |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5562901A true JPS5562901A (en) | 1980-05-12 |
| JPS5737161B2 JPS5737161B2 (en) | 1982-08-07 |
Family
ID=15168115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13613578A Granted JPS5562901A (en) | 1978-11-04 | 1978-11-04 | Preparation of high polymer having thyroliberyl group |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5562901A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108350796A (en) | 2015-10-26 | 2018-07-31 | 株式会社Ihi | Nozzle drive mechanism and supercharger |
-
1978
- 1978-11-04 JP JP13613578A patent/JPS5562901A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5737161B2 (en) | 1982-08-07 |
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