JPS5572182A - Optical resolution of pantolactone - Google Patents
Optical resolution of pantolactoneInfo
- Publication number
- JPS5572182A JPS5572182A JP14601178A JP14601178A JPS5572182A JP S5572182 A JPS5572182 A JP S5572182A JP 14601178 A JP14601178 A JP 14601178A JP 14601178 A JP14601178 A JP 14601178A JP S5572182 A JPS5572182 A JP S5572182A
- Authority
- JP
- Japan
- Prior art keywords
- pantolactone
- carboxylic acid
- organic carboxylic
- ester
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Furan Compounds (AREA)
Abstract
PURPOSE: To separate an optically active D-pantolactone ester of an organic carboxylic acid from L-pantolactone, by hydrolyzing a D,L-pantolactone ester of an organic carboxylic acid in the presence of a specific hydrolase.
CONSTITUTION: Hydrolase produced by microorganisms of the genus Aspergillus, enzyme No.E.C.3.1.1.3, e.g. lipase AP, is made to act on a D,L-pantolactone ester of an organic carboxylic acid in water as a solvent at a pH of 8.5W3.0 and -10W80°C to hydrolyze only the L-isomer. The optically active compound of the formula (R is alkyl or alkenyl group) is then separated from L-pantolactone by distillation.
USE: The hydrolyzed compound of formula is usable as a raw material for food additives and medicines, and L-pantolactone is a material by racemization.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14601178A JPS5572182A (en) | 1978-11-28 | 1978-11-28 | Optical resolution of pantolactone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14601178A JPS5572182A (en) | 1978-11-28 | 1978-11-28 | Optical resolution of pantolactone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5572182A true JPS5572182A (en) | 1980-05-30 |
Family
ID=15398066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14601178A Pending JPS5572182A (en) | 1978-11-28 | 1978-11-28 | Optical resolution of pantolactone |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5572182A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0794251A4 (en) * | 1995-09-13 | 2000-01-12 | Fuji Yakuhin Kogyo Kk | D-pantolactone hydrolase and gene encoding the same |
| WO2001032890A1 (en) * | 1999-10-29 | 2001-05-10 | Basf Aktiengesellschaft | L-pantolactone-hydrolase and a method for producing d-pantolactone |
| CN108102926A (en) * | 2017-11-27 | 2018-06-01 | 苏州百福安酶技术有限公司 | The Aspergillus niger strain BFA010-7 of the left-handed lactone hydrolase of high yield and its application in D-pantoyl lactone is prepared |
-
1978
- 1978-11-28 JP JP14601178A patent/JPS5572182A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0794251A4 (en) * | 1995-09-13 | 2000-01-12 | Fuji Yakuhin Kogyo Kk | D-pantolactone hydrolase and gene encoding the same |
| US6794171B2 (en) | 1995-09-13 | 2004-09-21 | Fuji Yakuhin Kogyo Kabushiki Kaisha | D-pantolactone hydrolase and gene encoding the same |
| WO2001032890A1 (en) * | 1999-10-29 | 2001-05-10 | Basf Aktiengesellschaft | L-pantolactone-hydrolase and a method for producing d-pantolactone |
| AU782517B2 (en) * | 1999-10-29 | 2005-08-04 | Basf Aktiengesellschaft | L-pantolactone-hydrolase and a method for producing D-pantolactone |
| CN108102926A (en) * | 2017-11-27 | 2018-06-01 | 苏州百福安酶技术有限公司 | The Aspergillus niger strain BFA010-7 of the left-handed lactone hydrolase of high yield and its application in D-pantoyl lactone is prepared |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU94019422A (en) | Method of fluorinated carboxylic acids isolation | |
| SE8206580L (en) | PREPARATION OF 3-HYDROXY-ML-236B DERIVATE | |
| FI890388A0 (en) | Process for Preparation of (S) -ketoprofen | |
| GR3008107T3 (en) | ||
| KR860000236A (en) | Process for producing ester of triterphenyl of organic acid | |
| JPS5572182A (en) | Optical resolution of pantolactone | |
| BE889728A (en) | PROCESS FOR THE PRODUCTION OF THE ENZYME CHOLESTERASE AND HYDROLYSIS OF FATTY ACID CHOLESTEROL ESTERS USING THE ENZYME ITSELF | |
| JPS54119593A (en) | Biodegradation of copolyester-amide | |
| JPS5648888A (en) | Preparation of optical active compound | |
| JPS57198098A (en) | Preparation of optically active monoester monocarboxylic acid | |
| JPS57152894A (en) | Preparation of optically active carboxylic acid ester and optically active carboxylic acid | |
| JPS53147018A (en) | Preparation of carboxylic acid glycidyl ester | |
| JPS54144332A (en) | Racemization of optically active 2-(4-chlorophenyl)-3- methylbutyric acid | |
| JPS55118428A (en) | Biochemical resolution | |
| AU585703B2 (en) | Process for the enzymatic resolution of racemic 2-amino- 1-alkanols | |
| EP0264429A4 (en) | ENZYMATIC PROCESS FOR PREPARING OPTICALLY-ACTIVE 1,2-DIHYDRO-3H-PYRROLO 1,2a]PYRROLE-1-CARBOXYLIC ACID DERIVATIVES. | |
| JPS5332194A (en) | Resolution of dl-lysine | |
| JPS57155967A (en) | Hydrolysis of protein and enzyme therefor | |
| JPS57132891A (en) | Preparation of optically active beta-(s)-aminoglutaric monoalkyl ester | |
| JP2555129B2 (en) | Optical resolution of (±) -1-para-substituted phenylethanol | |
| JPS5771395A (en) | Preparation of optically active monoalkyl beta-(r)-aminoglutarate | |
| JPS6463539A (en) | Optically active ethanol derivative and production thereof | |
| ES2055122T3 (en) | PROCEDURE FOR THE PREPARATION OF 2-ARYLOXY- OR 2-ARYLTIO-ALCANOIC ACIDS. | |
| JPS57115184A (en) | Preparation of optical active (s)-beta-aminoglutaric acid monoalkyl ester | |
| JPS57177696A (en) | Production of optically active beta-(s)-aminoglutaric monoalkyl ester |