JPS5771395A - Preparation of optically active monoalkyl beta-(r)-aminoglutarate - Google Patents

Preparation of optically active monoalkyl beta-(r)-aminoglutarate

Info

Publication number
JPS5771395A
JPS5771395A JP14634580A JP14634580A JPS5771395A JP S5771395 A JPS5771395 A JP S5771395A JP 14634580 A JP14634580 A JP 14634580A JP 14634580 A JP14634580 A JP 14634580A JP S5771395 A JPS5771395 A JP S5771395A
Authority
JP
Japan
Prior art keywords
aminoglutarate
monoalkyl
ester
beta
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14634580A
Other languages
Japanese (ja)
Inventor
Masaji Ono
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP14634580A priority Critical patent/JPS5771395A/en
Priority to AT81108343T priority patent/ATE10835T1/en
Priority to EP81108343A priority patent/EP0050799B1/en
Priority to DE8181108343T priority patent/DE3167862D1/en
Publication of JPS5771395A publication Critical patent/JPS5771395A/en
Pending legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain a β-(R)-aminoglutaric monoester, having an antimicrobial activity, and capable of being a synthetic intermediate for thienamycin, by hydrolyzing a dialkyl β-aminoglutarate with an ester hydrolytic enzyme.
CONSTITUTION: A dialkyl β-aminoglutarate of formulaIis treated with an esterase derived from a hog liver in a phosphoric acid buffer solution at a pH of 8.0 and 25°C for 1.5hr, and the resultant product is then extracted under neutral conditions and purified to give a monoalkyl β-(R)-aminoglutarate of formula II. The methyl and the ethyl esters exhibit an antimicrobial activity against staphylococci and is easily converted into a synthetic intermediate for thienamycin. Furthermore, the resultant monoalkyl ester can be converted into a β-(S)-aminoglutaric monoester by the ester interchange.
COPYRIGHT: (C)1982,JPO&Japio
JP14634580A 1980-10-21 1980-10-21 Preparation of optically active monoalkyl beta-(r)-aminoglutarate Pending JPS5771395A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP14634580A JPS5771395A (en) 1980-10-21 1980-10-21 Preparation of optically active monoalkyl beta-(r)-aminoglutarate
AT81108343T ATE10835T1 (en) 1980-10-21 1981-10-15 PROCESS FOR THE PRODUCTION OF DI-ALKYLESTERS AND OPTICALLY ACTIVE MONO-ALKYLESTERS OF 3AMINOGLUTARS[URE.
EP81108343A EP0050799B1 (en) 1980-10-21 1981-10-15 New processes for the production of di-alkyl esters and optically active mono-alkyl esters of 3-aminoglutaric acid
DE8181108343T DE3167862D1 (en) 1980-10-21 1981-10-15 New processes for the production of di-alkyl esters and optically active mono-alkyl esters of 3-aminoglutaric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14634580A JPS5771395A (en) 1980-10-21 1980-10-21 Preparation of optically active monoalkyl beta-(r)-aminoglutarate

Publications (1)

Publication Number Publication Date
JPS5771395A true JPS5771395A (en) 1982-05-04

Family

ID=15405597

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14634580A Pending JPS5771395A (en) 1980-10-21 1980-10-21 Preparation of optically active monoalkyl beta-(r)-aminoglutarate

Country Status (1)

Country Link
JP (1) JPS5771395A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01225489A (en) * 1988-03-07 1989-09-08 Dai Ichi Seiyaku Co Ltd Production of optically active bisacetic acid monoester

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01225489A (en) * 1988-03-07 1989-09-08 Dai Ichi Seiyaku Co Ltd Production of optically active bisacetic acid monoester

Similar Documents

Publication Publication Date Title
ATE146519T1 (en) METHOD FOR PRODUCING FATTY ACID ALKYL ESTERS
ATE8995T1 (en) HYDROXYLALKYL PURINE ESTER, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THESE ESTERS AS ACTIVE INGREDIENTS.
BE889728A (en) PROCESS FOR THE PRODUCTION OF THE ENZYME CHOLESTERASE AND HYDROLYSIS OF FATTY ACID CHOLESTEROL ESTERS USING THE ENZYME ITSELF
ES8206624A1 (en) Process for esterification of alpha -L-aspartyl-L-phenylalanine
JPS5771395A (en) Preparation of optically active monoalkyl beta-(r)-aminoglutarate
JPS57198098A (en) Preparation of optically active monoester monocarboxylic acid
DE3664212D1 (en) Process for preparing l-homoalanin-4-yl(methyl)-phosphinic acids, as well as their alkyl esters
JPS578787A (en) Esterification by enzyme
GB1496492A (en) Optically active lysergic acid derivatives
DE69033833D1 (en) Process for the preparation of butanetetracarboxylic acid
Mounter et al. Specificity and properties of wheat-germ esterase
FR2431496A1 (en) PROCESS FOR THE PREPARATION OF 10-BROMO-VINCAMINIC ACID ESTERS AND SIMILAR COMPOUNDS
JPS5771394A (en) Preparation of optically active monoalkyl beta-(s)-aminoglutarate
ZA916502B (en) Process for the preparation of aminomethylphosphonic acid and aminomethylphosphinic acids
JPS57212105A (en) Plant growth regulating agent
DE3585646D1 (en) FERMENTATION METHOD FOR THE PRODUCTION OF CARBONIC ACID ALKYL ESTERS.
JPS557244A (en) Ester interchange by use of alkoxy copper phenoxide
JPS5572182A (en) Optical resolution of pantolactone
JPS57152894A (en) Preparation of optically active carboxylic acid ester and optically active carboxylic acid
JPS57115184A (en) Preparation of optical active (s)-beta-aminoglutaric acid monoalkyl ester
JPS579784A (en) Production of penem-3-carboxylic derivative
FR2364923A1 (en) NEW PHOSPHORIC ESTER AMIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS INSECTICIDES AND ACARICIDES
AU561146B2 (en) Fermentation process to produce lower alkyl esters of alpha- l-aspartyl-lphenyl-alanine
DE59103853D1 (en) Process for the resolution of 2,2-dimethylcyclopropanecarboxylic acid.
IT1200462B (en) METHYL DIPHYPHONIC ACID ESTER HYDROLYSIS PROCEDURE SUBSTITUTED