JPS5585592A - Demethylmaytansinoid compound - Google Patents
Demethylmaytansinoid compoundInfo
- Publication number
- JPS5585592A JPS5585592A JP16078778A JP16078778A JPS5585592A JP S5585592 A JPS5585592 A JP S5585592A JP 16078778 A JP16078778 A JP 16078778A JP 16078778 A JP16078778 A JP 16078778A JP S5585592 A JPS5585592 A JP S5585592A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- demethylmaytansinoid
- maytansinoid
- bacillus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Demethylmaytansinoid compounds of formula I (X is Cl or H; R1 is H, acyl). USE:Antimildew and antiprotozoal. Antitumorigenic agent. They have low toxicity. They also are useful as synthetic intermeidates of medicines. PREPARATION:A microorganism that belongs to Bacillus, Streptomyces or Actynomyces, capable of converting the methoxy group in the 20 position of a maytansinoid of formula II into hydroxyl group, or its treated product is brought into contact with a maytansinoid compound of formula II to form title compound of formula I. The microoranism is, e.g., Bacillus megaterium (IFO-12108) and the concentration of the compound in the reaction mixture is preferably 1-20 microgram/ml, the temperature is 20-50 deg.C and the pH is suitably 5-10. The reaction is effected under standing or shaking or air-passing or stirring.
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16078778A JPS5585592A (en) | 1978-12-22 | 1978-12-22 | Demethylmaytansinoid compound |
| GR58533A GR63147B (en) | 1978-03-24 | 1979-03-07 | Preparation process of demethyl maytansinoids |
| ES478706A ES478706A1 (en) | 1978-03-24 | 1979-03-16 | Demethyl maytansinoids and methods for producing them. |
| CA000323717A CA1144096A (en) | 1978-03-24 | 1979-03-19 | Demethyl maytansinoids |
| AU45246/79A AU519911B2 (en) | 1978-03-24 | 1979-03-19 | Demethyl maytansinoids |
| PL1979214307A PL124051B1 (en) | 1978-03-24 | 1979-03-22 | Process for preparing novel demethylmaytansynoidic compounds |
| PT69382A PT69382A (en) | 1978-03-24 | 1979-03-22 | Demethyl maytansinoids |
| DE7979300469T DE2961940D1 (en) | 1978-03-24 | 1979-03-23 | Demethyl maytansinoids and methods for producing them |
| AT0219179A AT362872B (en) | 1978-03-24 | 1979-03-23 | METHOD FOR PRODUCING NEW DEMETHYLMAYTANSINOIDS |
| EP79300469A EP0004466B1 (en) | 1978-03-24 | 1979-03-23 | Demethyl maytansinoids and methods for producing them |
| DK121279A DK121279A (en) | 1978-03-24 | 1979-03-23 | DEMETHYLMAYTANSINOIDS AND METHODS FOR MANUFACTURE THEREOF |
| US06/153,522 US4307016A (en) | 1978-03-24 | 1980-05-27 | Demethyl maytansinoids |
| US06/290,943 US4361650A (en) | 1978-03-24 | 1981-08-07 | Fermentation process of preparing demethyl maytansinoids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16078778A JPS5585592A (en) | 1978-12-22 | 1978-12-22 | Demethylmaytansinoid compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5585592A true JPS5585592A (en) | 1980-06-27 |
| JPS6213958B2 JPS6213958B2 (en) | 1987-03-30 |
Family
ID=15722432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16078778A Granted JPS5585592A (en) | 1978-03-24 | 1978-12-22 | Demethylmaytansinoid compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5585592A (en) |
-
1978
- 1978-12-22 JP JP16078778A patent/JPS5585592A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6213958B2 (en) | 1987-03-30 |
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