JPS5587790A - Cephalosporin analog - Google Patents

Cephalosporin analog

Info

Publication number
JPS5587790A
JPS5587790A JP16200778A JP16200778A JPS5587790A JP S5587790 A JPS5587790 A JP S5587790A JP 16200778 A JP16200778 A JP 16200778A JP 16200778 A JP16200778 A JP 16200778A JP S5587790 A JPS5587790 A JP S5587790A
Authority
JP
Japan
Prior art keywords
formula
compound
carboxyl
reaction
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16200778A
Other languages
Japanese (ja)
Other versions
JPS5936915B2 (en
Inventor
Tadashi Hirata
Takehiro Ogasa
Hiromitsu Saito
Yoshihiro Nakamizo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP53162007A priority Critical patent/JPS5936915B2/en
Priority to NO790956A priority patent/NO790956L/en
Priority to SE7902599A priority patent/SE7902599L/en
Priority to DK120179A priority patent/DK120179A/en
Priority to AU45368/79A priority patent/AU527128B2/en
Priority to NL7902321A priority patent/NL7902321A/en
Priority to CA000324074A priority patent/CA1178956A/en
Priority to FR7907415A priority patent/FR2420538A1/en
Priority to DE2911787A priority patent/DE2911787C2/en
Priority to CH279079A priority patent/CH640855A5/en
Priority to IT67623/79A priority patent/IT1165187B/en
Priority to GB7910507A priority patent/GB2017103B/en
Publication of JPS5587790A publication Critical patent/JPS5587790A/en
Publication of JPS5936915B2 publication Critical patent/JPS5936915B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Cephalosporin analogs of formula I (X is acyl; R1 is H, carboxyl- protecting group) and their salts.
EXAMPLE: ( ± )cis-7β-[ ( R )-2-phenyl-2-aminoacetamide ]-4β-methyl-2-carboxy- 1-azabicyclo[4,2,0]oct-2-en-8-one trifluoroacetate.
USE: Antibiotic and its synthetic intermediates. The analogs with R1 of H has outstanding antibacterial activity against gram-positive and negative bacteria.
PREPARATION: For example, the reaction of a compound of formula II' and a carboxylic acid corresponding to acyl group X or its reactive derivative gives the compound of formula I. When necessary, a base is used in the reaction. When R1 is a carboxyl-protecting group, it is removed and the product is converted into the antibacterial compound with R1 of H.
COPYRIGHT: (C)1980,JPO&Japio
JP53162007A 1978-03-25 1978-12-26 Cephalosporin analogs Expired JPS5936915B2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP53162007A JPS5936915B2 (en) 1978-12-26 1978-12-26 Cephalosporin analogs
NO790956A NO790956L (en) 1978-03-25 1979-03-21 ANALOGICAL PROCEDURES FOR THE PREPARATION OF CEPHALOSPORINE ANALOG OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
SE7902599A SE7902599L (en) 1978-03-25 1979-03-22 CEPHALOSPIRINFORENINGAR
DK120179A DK120179A (en) 1978-03-25 1979-03-23 CEPHALOSPORINE ANALOG AND METHOD OF MANUFACTURE
AU45368/79A AU527128B2 (en) 1978-03-25 1979-03-23 Cephalosporin analogs
NL7902321A NL7902321A (en) 1978-03-25 1979-03-23 CEPHALOSPORIN DERIVATIVES.
CA000324074A CA1178956A (en) 1978-03-25 1979-03-23 Cephalosporin analogs
FR7907415A FR2420538A1 (en) 1978-03-25 1979-03-23 7-ACYLAMINO-1-CARBA-3-CEPHEM-4-CARBOXYLIC ACIDS, AS COMPOUNDS SIMILAR TO CEPHALOSPORIN, AND PROCESS FOR THE PREPARATION
DE2911787A DE2911787C2 (en) 1978-03-25 1979-03-26 Carbacephem derivatives and their uses
CH279079A CH640855A5 (en) 1978-03-25 1979-03-26 CEPHALOSPORIN ANALOGS AND METHOD FOR THE PRODUCTION THEREOF.
IT67623/79A IT1165187B (en) 1978-03-25 1979-03-26 Cephalosporin analogues and procedure for their preparation
GB7910507A GB2017103B (en) 1978-03-25 1979-03-26 Cephalosporin analogues

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53162007A JPS5936915B2 (en) 1978-12-26 1978-12-26 Cephalosporin analogs

Publications (2)

Publication Number Publication Date
JPS5587790A true JPS5587790A (en) 1980-07-02
JPS5936915B2 JPS5936915B2 (en) 1984-09-06

Family

ID=15746263

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53162007A Expired JPS5936915B2 (en) 1978-03-25 1978-12-26 Cephalosporin analogs

Country Status (1)

Country Link
JP (1) JPS5936915B2 (en)

Also Published As

Publication number Publication date
JPS5936915B2 (en) 1984-09-06

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