JPS5589257A - New easily-absorbable sulfur-containing prodrug of non- steroidal antiphlogistic, and their drug compositions - Google Patents

New easily-absorbable sulfur-containing prodrug of non- steroidal antiphlogistic, and their drug compositions

Info

Publication number: JPS5589257A
Authority: JP; Japan
Prior art keywords: formula; compounds; drug compositions; containing prodrug; steroidal
Prior art date: 1978-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP16746179A

Other languages

English (en)

Inventor

Esu Boodaa Nikorasu

Bii Suroon Kenesu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kanebo Ltd

Original Assignee

Kanebo Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-12-22

Filing date

1979-12-21

Publication date

1980-07-05

1979-12-21 Application filed by Kanebo Ltd filed Critical Kanebo Ltd

1980-07-05 Publication of JPS5589257A publication Critical patent/JPS5589257A/ja

Status Pending legal-status Critical Current

Links

230000001741 anti-phlogistic effect Effects 0.000 title abstract 3
230000003637 steroidlike Effects 0.000 title abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1
229910052717 sulfur Inorganic materials 0.000 title 1
239000011593 sulfur Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
210000004400 mucous membrane Anatomy 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000002085 irritant Substances 0.000 abstract 1
231100000021 irritant Toxicity 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
210000004379 membrane Anatomy 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
KBFOBMYHWKFFLX-UHFFFAOYSA-N methylsulfanylmethyl 2-hydroxybenzoate Chemical compound CSCOC(=O)C1=CC=CC=C1O KBFOBMYHWKFFLX-UHFFFAOYSA-N 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
239000012466 permeate Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Emergency Medicine (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

JP16746179A 1978-12-22 1979-12-21 New easily-absorbable sulfur-containing prodrug of non- steroidal antiphlogistic, and their drug compositions Pending JPS5589257A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US97224378A	1978-12-22	1978-12-22

Publications (1)

Publication Number	Publication Date
JPS5589257A true JPS5589257A (en)	1980-07-05

Family

ID=25519402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP16746179A Pending JPS5589257A (en)	1978-12-22	1979-12-21	New easily-absorbable sulfur-containing prodrug of non- steroidal antiphlogistic, and their drug compositions

Country Status (4)

Country	Link
JP (1)	JPS5589257A (ja)
DK (1)	DK551579A (ja)
NO (1)	NO148595C (ja)
SE (1)	SE7910590L (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS572252A (en) *	1980-04-21	1982-01-07	Merck & Co Inc	Novel precursor drug of biological activator containing mercapto group
CN106957251A (zh) *	2017-04-06	2017-07-18	武汉大学	一种制备烷基硫甲基酯类化合物的方法

1979
- 1979-12-21 DK DK551579A patent/DK551579A/da not_active Application Discontinuation
- 1979-12-21 NO NO794244A patent/NO148595C/no unknown
- 1979-12-21 JP JP16746179A patent/JPS5589257A/ja active Pending
- 1979-12-21 SE SE7910590A patent/SE7910590L/xx not_active Application Discontinuation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS572252A (en) *	1980-04-21	1982-01-07	Merck & Co Inc	Novel precursor drug of biological activator containing mercapto group
CN106957251A (zh) *	2017-04-06	2017-07-18	武汉大学	一种制备烷基硫甲基酯类化合物的方法

Also Published As

Publication number	Publication date
NO148595C (no)	1983-11-09
SE7910590L (sv)	1980-06-23
NO148595B (no)	1983-08-01
NO794244L (no)	1980-06-24
DK551579A (da)	1980-06-23

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