JPS56103192A - Novel platinum complex - Google Patents

Novel platinum complex

Info

Publication number
JPS56103192A
JPS56103192A JP440380A JP440380A JPS56103192A JP S56103192 A JPS56103192 A JP S56103192A JP 440380 A JP440380 A JP 440380A JP 440380 A JP440380 A JP 440380A JP S56103192 A JPS56103192 A JP S56103192A
Authority
JP
Japan
Prior art keywords
formula
compound
stilbenediamine
platinum complex
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP440380A
Other languages
Japanese (ja)
Inventor
Yoshinori Kitani
Masahide Nomichi
Hiromi Gochi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP440380A priority Critical patent/JPS56103192A/en
Publication of JPS56103192A publication Critical patent/JPS56103192A/en
Pending legal-status Critical Current

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NEW MATERIAL:A platinum complex of formula I (R1 and R2 are the same and halogen or NO3 or different SO4 or OH2 or together form group of formula II; the steric configuration of stilbenediamine is meso, trans-d-, or trans-l-).
EXAMPLE: Dichloro(meso-stilbenediamine)platinum (II) complex.
USE: An antitumor agent.
PROCESS: s-Stilbenediamine is reacted with K2PtX4 (X is halogen) in a solvent, e.g. water, to give the compound of formula I (R1 is R2 are X), which is then reacted with AgNO3 or Ag2SO4 if necessary to afford the compound of formula I (R1 and R2 are NO3, SO4 and OH2). The resultant compound is further reacted with a D-glucuronate and converted into the compound of formula I (R1 and R2 are groups of formula II).
COPYRIGHT: (C)1981,JPO&Japio
JP440380A 1980-01-18 1980-01-18 Novel platinum complex Pending JPS56103192A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP440380A JPS56103192A (en) 1980-01-18 1980-01-18 Novel platinum complex

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP440380A JPS56103192A (en) 1980-01-18 1980-01-18 Novel platinum complex

Publications (1)

Publication Number Publication Date
JPS56103192A true JPS56103192A (en) 1981-08-18

Family

ID=11583359

Family Applications (1)

Application Number Title Priority Date Filing Date
JP440380A Pending JPS56103192A (en) 1980-01-18 1980-01-18 Novel platinum complex

Country Status (1)

Country Link
JP (1) JPS56103192A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598091A (en) * 1983-02-18 1986-07-01 Degussa Aktiengesellschaft (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds
EP0219936A1 (en) 1985-08-27 1987-04-29 Nippon Kayaku Kabushiki Kaisha Novel platinum complexes
US4956459A (en) * 1987-07-17 1990-09-11 Georgetown University Platinum compounds suitable for use as pharmaceuticals
WO1996035696A1 (en) * 1995-05-09 1996-11-14 Kreatech Biotechnology B.V. Methods for the production of platinum-based linkers between labels and bio-organic molecules, for labelling bio-organic molecules, for detecting biological substances of interest and diagnostic test kits
EP1068870A4 (en) * 1998-04-03 2003-02-12 Ajinomoto Kk ANTITUMOR AGENTS

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598091A (en) * 1983-02-18 1986-07-01 Degussa Aktiengesellschaft (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds
EP0219936A1 (en) 1985-08-27 1987-04-29 Nippon Kayaku Kabushiki Kaisha Novel platinum complexes
EP0219936B1 (en) * 1985-08-27 1989-12-13 Nippon Kayaku Kabushiki Kaisha Novel platinum complexes
US4956459A (en) * 1987-07-17 1990-09-11 Georgetown University Platinum compounds suitable for use as pharmaceuticals
WO1996035696A1 (en) * 1995-05-09 1996-11-14 Kreatech Biotechnology B.V. Methods for the production of platinum-based linkers between labels and bio-organic molecules, for labelling bio-organic molecules, for detecting biological substances of interest and diagnostic test kits
EP1068870A4 (en) * 1998-04-03 2003-02-12 Ajinomoto Kk ANTITUMOR AGENTS
KR100598474B1 (en) * 1998-04-03 2006-07-11 아지노모토 가부시키가이샤 Antitumor agents

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