JPS5629549A - Preparation of 1-aryloxy-3-isopropylaminopropan-2-ol - Google Patents
Preparation of 1-aryloxy-3-isopropylaminopropan-2-olInfo
- Publication number
- JPS5629549A JPS5629549A JP10535179A JP10535179A JPS5629549A JP S5629549 A JPS5629549 A JP S5629549A JP 10535179 A JP10535179 A JP 10535179A JP 10535179 A JP10535179 A JP 10535179A JP S5629549 A JPS5629549 A JP S5629549A
- Authority
- JP
- Japan
- Prior art keywords
- isopropylamine
- amine
- epoxy compound
- low
- stabilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004593 Epoxy Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- -1 4-indolyl Chemical group 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004327 boric acid Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000007142 ring opening reaction Methods 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 238000009834 vaporization Methods 0.000 abstract 1
- 230000008016 vaporization Effects 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as a remedy for cardiopathy such as arrythmia, etc., easily, in high yield, in a short time, at a low temperature, by treating isopropylamine with a weak acid, and reacting thus stabilized isopropylamine with a specific epoxy compound.
CONSTITUTION: An epoxy compound of formula I (Ar is 1-naphthyl or 4-indolyl) is made to react with a stabilized isopropylamine to afford 1-aryloxy-3-isopropylaminopropan-2-ol of formula II. The stabilization of isopropylamine is carried out by treating the amine with stoichiometric neutralization amount of organic monobasic or dibasic acid having a 1W10C straight or branched chain, or substituted or nonsubstituted aromatic or heterocyclic group, or an inorganic weak acid such as boric acid, monoalkali phosphate, etc., as an agent for preventing the vaporization of a low-boiling amine and promoting the ring-opening reaction of epoxy ring. The reaction temperature is 20W50°C. The amount of the amine is as low as 1W1.3 times mole of the epoxy compound.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10535179A JPS5629549A (en) | 1979-08-18 | 1979-08-18 | Preparation of 1-aryloxy-3-isopropylaminopropan-2-ol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10535179A JPS5629549A (en) | 1979-08-18 | 1979-08-18 | Preparation of 1-aryloxy-3-isopropylaminopropan-2-ol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5629549A true JPS5629549A (en) | 1981-03-24 |
Family
ID=14405303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10535179A Pending JPS5629549A (en) | 1979-08-18 | 1979-08-18 | Preparation of 1-aryloxy-3-isopropylaminopropan-2-ol |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5629549A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485258A (en) * | 1981-08-20 | 1984-11-27 | Mitsubishi Chemical Industries Limited | Pharmaceutically active (3-aminopropoxy)bibenzyl derivatives |
-
1979
- 1979-08-18 JP JP10535179A patent/JPS5629549A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485258A (en) * | 1981-08-20 | 1984-11-27 | Mitsubishi Chemical Industries Limited | Pharmaceutically active (3-aminopropoxy)bibenzyl derivatives |
| US4599419A (en) * | 1981-08-20 | 1986-07-08 | Mitsubishi Chemical Industries, Inc. | Pharmaceutically active (3-cyclic aminopropoxy)bibenzyls as inhibitors of platelet aggregation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8707731A1 (en) | A PROCEDURE FOR THE PREPARATION OF OXINDOL DERIVATIVES | |
| JPS5629549A (en) | Preparation of 1-aryloxy-3-isopropylaminopropan-2-ol | |
| ES2056072T3 (en) | ACID PREPARATION PROCEDURES (+/-) - 1,2-DIHYDRO-3H-PIRROLO (1,2-A) PIRROL-1-CARBOXILICO AND RELATED COMPOUNDS. | |
| GB1078410A (en) | New secondary amines and process for their manufacture | |
| GB1211625A (en) | Process for the production of n-carboxy anhydrides of amino acids and derivatives thereof | |
| JPS5562094A (en) | Preparation of phosphoric acid ester and thiophosphoric acid ester | |
| JPS5629550A (en) | Novel preparation of 1-aryloxy-3-isopropylaminopropan-2-ol | |
| ES8105303A1 (en) | A process for the preparation of substituted 2-aminopyrazines. | |
| JPS5592348A (en) | Preparation of 1,17-diamino-9-azaheptadecane | |
| JPS5476544A (en) | Preparation of p-cyanophenol | |
| JPS5750953A (en) | Preparation of hydroxybenzonitriles | |
| JPS5444675A (en) | Production of 3-hydroxy-4-pyrone analog | |
| JPS57188551A (en) | N-(p-chloro-alpha-methylbenzyl)-alpha-bromo-tert-pentylacetamide, its preparation, and agricultural and horticultural fungicide containing said compound as active component | |
| JPS5726677A (en) | Preparation of oxirane compound | |
| JPS54125629A (en) | Preparation of azine | |
| ES8604901A1 (en) | A PROCEDURE FOR THE PREPARATION OF A TRIAZOLE | |
| JPS5547639A (en) | Preparation of alkylanthraquinone | |
| JPS55102561A (en) | 2-aroylformyl-substituted pyrrole derivative and its preparation | |
| JPS5742679A (en) | Preparation of phenylpiperazine derivative | |
| GB890477A (en) | New biguanides and process for their manufacture | |
| ES2121917T3 (en) | A COMPOSITION WITH ANTIOZONANTE ACTIVITY IN RUBBER THAT CONTAINS DIENE. | |
| JPS5659727A (en) | Preparation of substituted phenol | |
| JPS54157555A (en) | Preparation of ester | |
| JPS55139346A (en) | Preparation of bis(8-guanidinooctyl)amine acetic acid salt | |
| JPS5350187A (en) | Preparation of plyisocyanates |