JPS562985A - Spiro compound and its preparation - Google Patents
Spiro compound and its preparationInfo
- Publication number
- JPS562985A JPS562985A JP7776279A JP7776279A JPS562985A JP S562985 A JPS562985 A JP S562985A JP 7776279 A JP7776279 A JP 7776279A JP 7776279 A JP7776279 A JP 7776279A JP S562985 A JPS562985 A JP S562985A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- spiro
- lower alkyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003413 spiro compounds Chemical class 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical class OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A spiro compound of formula I (R1 is H or lower alkyl; R2 is lower alkyl; R3 is esterified carboxy).
EXAMPLE: 1, 5-Dimethyl-3-oxo-4-ethoxycarbonyl-4-pyrroline-2-spiro-4'-( 1'-isonicotinoyl-1',4'-dihydropyridine).
USE: Medicine having antispasmodic and sedative activities.
PROCESS: The compound of formula I is prepared by reacting 1mol of a compound of formula II with >1mol, pref. about 4mol of a reactive derivative of isonicotinic acid of formula III (e.g. acid chloride, acid bromide, active ester, etc.) in a solvent such as methylene chloride, benzene, etc., under heating.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7776279A JPS562985A (en) | 1979-06-19 | 1979-06-19 | Spiro compound and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7776279A JPS562985A (en) | 1979-06-19 | 1979-06-19 | Spiro compound and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS562985A true JPS562985A (en) | 1981-01-13 |
Family
ID=13642938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7776279A Pending JPS562985A (en) | 1979-06-19 | 1979-06-19 | Spiro compound and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS562985A (en) |
-
1979
- 1979-06-19 JP JP7776279A patent/JPS562985A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS562985A (en) | Spiro compound and its preparation | |
| JPS5791953A (en) | 4-fluoro-4'-hydroxybiphenyl benzoic acid ester derivative | |
| JPS5576852A (en) | Novel derivative of anthranilic acid | |
| JPS55154950A (en) | Novel carboxylic acid amide derivative | |
| JPS5566592A (en) | 7-alkoxythiazolo 3,2-a pyrimidine derivative, its preparation, and drug containing the same | |
| JPS57212188A (en) | Imidazobenzoxazine derivative and its preparation | |
| JPS5562082A (en) | Tetrahydroxanthone derivative | |
| JPS5522617A (en) | 2-chloro-5-trichloromethylpyridine and its preparation | |
| JPS55104273A (en) | 4-phenylisoxazole derivative and its preparation | |
| JPS5620577A (en) | 4- n-alkylanilino quinazoline derivative and its preparation | |
| JPS54115356A (en) | 1-substituted-5,6,-dithiocalicene derivative and its preparation | |
| JPS5679700A (en) | 2'-deoxyguanosine derivative and its preparation | |
| JPS5625166A (en) | 5-fluorouracil derivative | |
| JPS55104266A (en) | Novel pyridone derivative | |
| JPS55108883A (en) | Ethyl-(gamma-acetamino-gamma-ethoxycarbonyl-gamma-cyanopropyl- methyl) phosphinate and its preparation | |
| JPS55147279A (en) | Preparation of 2,3-dipyridylquinazolinone derivative | |
| JPS5795940A (en) | 3-(2,2-dihalogenovinyloxy)-alpha-ethynylbenzyl ester and insecticide containing the same as active constituent | |
| JPS5679668A (en) | 1,4-dihydro-4-oxonicotinic acid derivatice and its preparation | |
| JPS55104274A (en) | Isoxazolin-3-one derivative and its preparation | |
| JPS5781479A (en) | Novel lactone and its preparation | |
| JPS5618985A (en) | Furoindole compound | |
| JPS5612390A (en) | Triazolopyridazine derivative | |
| JPS55147278A (en) | Nicotinoylaminotriazine derivative | |
| JPS54138574A (en) | 1,2,3,4-tetrahydroisoquinoline derivative | |
| JPS5721348A (en) | 2- 1-methyl-2-propenyl -3-hydroxyundecanoic derivative |