JPS5630933A - Production of diterpene alcohol - Google Patents
Production of diterpene alcoholInfo
- Publication number
- JPS5630933A JPS5630933A JP10789479A JP10789479A JPS5630933A JP S5630933 A JPS5630933 A JP S5630933A JP 10789479 A JP10789479 A JP 10789479A JP 10789479 A JP10789479 A JP 10789479A JP S5630933 A JPS5630933 A JP S5630933A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- molecular compound
- extract
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 4
- 229930004069 diterpene Natural products 0.000 title abstract 3
- 150000004141 diterpene derivatives Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000001110 calcium chloride Substances 0.000 abstract 3
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 2
- 241001448862 Croton Species 0.000 abstract 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 2
- 229910021380 Manganese Chloride Inorganic materials 0.000 abstract 2
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 abstract 2
- 239000011565 manganese chloride Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910021586 Nickel(II) chloride Inorganic materials 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 229910001622 calcium bromide Inorganic materials 0.000 abstract 1
- WGEFECGEFUFIQW-UHFFFAOYSA-L calcium dibromide Chemical compound [Ca+2].[Br-].[Br-] WGEFECGEFUFIQW-UHFFFAOYSA-L 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910001623 magnesium bromide Inorganic materials 0.000 abstract 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 abstract 1
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
- 229940099607 manganese chloride Drugs 0.000 abstract 1
- 235000002867 manganese chloride Nutrition 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: A diterpene alcohol in the extract from a croton plant is made into a solid molecular compound by the use of a compound such as calcium or manganese chloride and the molecular compound is readily decomposed with water to give the titled high-purity compound having activity of resisting peptic ulcer.
CONSTITUTION: A croton plant is extracted with a solvent such as methanol (the addition of aqueous sodium hydroxide is preferred) and a diterpene alcohol of the formula is isolated from the extract and purified wherein a compound of the formula: MX2 (M is divalent metal; X is halogen) such as CaCl2, MnCl2, MgCl2, CaBr2, MgBr2 or NiCl2 in which CaCl2 is the most suitable, is brought into contact with the extract to form a solid molecular compound selectively and the molecular compound is separated. The molecular compound is decomposed only by adding water to isolate efficiently the compound of the formula. When the compound of the formula: MX2 is added, the addition of a catalyst amount of an alcohol such as methanol promotes the reaction.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10789479A JPS5630933A (en) | 1979-08-24 | 1979-08-24 | Production of diterpene alcohol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10789479A JPS5630933A (en) | 1979-08-24 | 1979-08-24 | Production of diterpene alcohol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5630933A true JPS5630933A (en) | 1981-03-28 |
Family
ID=14470758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10789479A Pending JPS5630933A (en) | 1979-08-24 | 1979-08-24 | Production of diterpene alcohol |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5630933A (en) |
-
1979
- 1979-08-24 JP JP10789479A patent/JPS5630933A/en active Pending
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