JPS5632461A - Preparation of 2,2,6,6-tetrakis (nicotinoyloxymethyl) cyclohexanol - Google Patents
Preparation of 2,2,6,6-tetrakis (nicotinoyloxymethyl) cyclohexanolInfo
- Publication number
- JPS5632461A JPS5632461A JP10932579A JP10932579A JPS5632461A JP S5632461 A JPS5632461 A JP S5632461A JP 10932579 A JP10932579 A JP 10932579A JP 10932579 A JP10932579 A JP 10932579A JP S5632461 A JPS5632461 A JP S5632461A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- chlorinating agent
- nicotinic acid
- agent
- cyclohexanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- VRAHPESAMYMDQI-UHFFFAOYSA-N Nicomol Chemical compound C1CCC(COC(=O)C=2C=NC=CC=2)(COC(=O)C=2C=NC=CC=2)C(O)C1(COC(=O)C=1C=NC=CC=1)COC(=O)C1=CC=CN=C1 VRAHPESAMYMDQI-UHFFFAOYSA-N 0.000 title 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 4
- 239000012320 chlorinating reagent Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000012024 dehydrating agents Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- ICVIFRMLTBUBGF-UHFFFAOYSA-N 2,2,6,6-tetrakis(hydroxymethyl)cyclohexan-1-ol Chemical compound OCC1(CO)CCCC(CO)(CO)C1O ICVIFRMLTBUBGF-UHFFFAOYSA-N 0.000 abstract 2
- 229960003512 nicotinic acid Drugs 0.000 abstract 2
- 235000001968 nicotinic acid Nutrition 0.000 abstract 2
- 239000011664 nicotinic acid Substances 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- VMKIGRVZOIQOBB-UHFFFAOYSA-N C(C1=CN=CC=C1)(=O)O.C1(CCCCC1)N=C=NC1CCCCC1 Chemical compound C(C1=CN=CC=C1)(=O)O.C1(CCCCC1)N=C=NC1CCCCC1 VMKIGRVZOIQOBB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 abstract 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002351 wastewater Substances 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound in high yields by a simple operation without fear of pollution, by reacting nicotinic acid or its salt with 2,2,6,6-tetramethylolcyclohexanol in the presence of a chlorinating agent or dehydrating agent.
CONSTITUTION: In the presence of a chlorinating agent such as thionyl chloride, sulfuryl chloride, phosphorus pentachloride, phosphorus trichloride, phosphorus oxychloride, or a dehydrating agent such as dicyclohexylcarbodiimide nicotinic acid or its salt is reacted with 2,2,6,6-tetramethylolcyclohexanol, to give the desired compound shown by the formula. An amount of nicotinic acid or its salt is 2W10mol based on 1mol of cyclohexanol as a raw material, and an amount of the chlorinating agent or dehydrating agent is about 1W5mol.
EFFECT: High-purity product is obtained. When a chlorinating agent is used, waste water is only neutralized by an alkali so that there is no problem at all.
USE: A compound effective against atherosclerosis.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10932579A JPS5632461A (en) | 1979-08-28 | 1979-08-28 | Preparation of 2,2,6,6-tetrakis (nicotinoyloxymethyl) cyclohexanol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10932579A JPS5632461A (en) | 1979-08-28 | 1979-08-28 | Preparation of 2,2,6,6-tetrakis (nicotinoyloxymethyl) cyclohexanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5632461A true JPS5632461A (en) | 1981-04-01 |
Family
ID=14507360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10932579A Pending JPS5632461A (en) | 1979-08-28 | 1979-08-28 | Preparation of 2,2,6,6-tetrakis (nicotinoyloxymethyl) cyclohexanol |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5632461A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58210362A (en) * | 1982-05-18 | 1983-12-07 | エキップマン エレクトロニク モツール | Starter for heat engine with supporter reinforcing member |
-
1979
- 1979-08-28 JP JP10932579A patent/JPS5632461A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58210362A (en) * | 1982-05-18 | 1983-12-07 | エキップマン エレクトロニク モツール | Starter for heat engine with supporter reinforcing member |
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