JPS5636468A - 44hydroxyy66arylpyrimidines - Google Patents

44hydroxyy66arylpyrimidines

Info

Publication number
JPS5636468A
JPS5636468A JP11016380A JP11016380A JPS5636468A JP S5636468 A JPS5636468 A JP S5636468A JP 11016380 A JP11016380 A JP 11016380A JP 11016380 A JP11016380 A JP 11016380A JP S5636468 A JPS5636468 A JP S5636468A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11016380A
Other languages
English (en)
Other versions
JPS578107B2 (ja
Inventor
Jiyooji Do Anjierisu Gerarudo
Jiyaagen Aansuto Hesu Hansu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Original Assignee
PFIZER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER filed Critical PFIZER
Publication of JPS5636468A publication Critical patent/JPS5636468A/ja
Publication of JPS578107B2 publication Critical patent/JPS578107B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP11016380A 1970-10-05 1980-08-11 44hydroxyy66arylpyrimidines Granted JPS5636468A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7821670A 1970-10-05 1970-10-05

Publications (2)

Publication Number Publication Date
JPS5636468A true JPS5636468A (en) 1981-04-09
JPS578107B2 JPS578107B2 (ja) 1982-02-15

Family

ID=22142671

Family Applications (2)

Application Number Title Priority Date Filing Date
JP7823771A Pending JPS5648511B1 (ja) 1970-10-05 1971-10-05
JP11016380A Granted JPS5636468A (en) 1970-10-05 1980-08-11 44hydroxyy66arylpyrimidines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP7823771A Pending JPS5648511B1 (ja) 1970-10-05 1971-10-05

Country Status (16)

Country Link
US (1) US3707560A (ja)
JP (2) JPS5648511B1 (ja)
AT (4) AT314540B (ja)
AU (1) AU465734B2 (ja)
BE (1) BE773484A (ja)
CA (1) CA988519A (ja)
CH (4) CH554346A (ja)
DE (2) DE2149249C3 (ja)
DK (1) DK131858C (ja)
ES (4) ES395676A1 (ja)
FI (1) FI55502C (ja)
FR (1) FR2110227B1 (ja)
GB (2) GB1373536A (ja)
NL (1) NL168511C (ja)
SE (2) SE390304B (ja)
ZA (1) ZA716615B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01279874A (ja) * 1988-01-29 1989-11-10 Ube Ind Ltd ４―ヒドロキシピリミジン類の製造方法
JP2009164373A (ja) * 2008-01-08 2009-07-23 Toshiba Corp 半導体装置

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3908012A (en) * 1970-10-05 1975-09-23 Pfizer Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
US3895112A (en) * 1970-10-05 1975-07-15 Pfizer Arylpyrimidines in the relaxation of smooth muscle
US3859288A (en) * 1970-10-05 1975-01-07 Pfizer Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
US3835132A (en) * 1972-02-01 1974-09-10 Shell Oil Co Morpholino-piperazinyl pyrimidines
US3950525A (en) * 1973-06-19 1976-04-13 Pfizer Inc. Relaxation of smooth muscle in a mammal
DE2343419A1 (de) * 1973-08-29 1975-03-13 Gruenenthal Chemie Verfahren zur herstellung von pyrimidinderivaten
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
US4935516A (en) * 1988-01-29 1990-06-19 Ube Industries, Ltd. Process for preparing 4-hydroxypyrimidine
DE3825647A1 (de) * 1988-07-28 1990-02-01 Geyer Gmbh & Co Christian Vorrichtung zur befestigung eines elektrischen schaltgeraetes
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
EP1196411B1 (en) 1999-07-15 2003-09-17 Pharmacopeia, Inc. Bradykinin b1 receptor antagonists
AU2003214110A1 (en) * 2002-03-15 2003-09-29 Ciba Specialty Chemicals Holding Inc. 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces
PL375552A1 (en) * 2002-05-22 2005-11-28 Amgen Inc. Vanilloid receptor ligands and their medical applications
WO2004085433A2 (en) * 2003-03-28 2004-10-07 Pharmacia & Upjohn Company Llc Positive allosteric modulators of the nicotinic acetylcholine receptor
WO2006113769A1 (en) * 2005-04-15 2006-10-26 Amgen Inc. Vanilloid receptor ligands and their use in treatments
CN102811620B (zh) * 2010-01-25 2015-03-25 Chdi基金会股份有限公司 一些犬尿氨酸-3-单加氧酶抑制剂、药物组合物及其使用方法
BR112014004741B1 (pt) 2011-08-30 2021-10-13 Chdi Foundation, Inc Entidade química, seu uso e composição farmacêutica compreendendo a mesma
AU2012300246A1 (en) 2011-08-30 2014-03-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
AU2015289492B2 (en) 2014-07-17 2020-02-20 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3047462A (en) * 1959-03-06 1962-07-31 Lab Jacques Logeais Soc D Expl Quinazolone anti-inflammatory composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3047462A (en) * 1959-03-06 1962-07-31 Lab Jacques Logeais Soc D Expl Quinazolone anti-inflammatory composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01279874A (ja) * 1988-01-29 1989-11-10 Ube Ind Ltd ４―ヒドロキシピリミジン類の製造方法
JP2009164373A (ja) * 2008-01-08 2009-07-23 Toshiba Corp 半導体装置

Also Published As

Publication number Publication date
CH554876A (fr) 1974-10-15
GB1373535A (en) 1974-11-13
AU3425971A (en) 1973-04-12
DE2149249B2 (de) 1974-11-07
ES420211A1 (es) 1976-03-16
JPS5648511B1 (ja) 1981-11-16
CH542218A (fr) 1973-11-15
ES420209A1 (es) 1976-06-01
NL168511B (nl) 1981-11-16
FR2110227A1 (ja) 1972-06-02
DE2149249C3 (de) 1975-07-03
GB1373536A (en) 1974-11-13
AT317229B (de) 1974-08-26
CA988519A (en) 1976-05-04
ZA716615B (en) 1972-06-28
DE2165962C2 (de) 1982-05-13
ES420210A1 (es) 1976-06-01
NL168511C (nl) 1982-04-16
BE773484A (fr) 1972-04-05
CH554875A (fr) 1974-10-15
NL7113670A (ja) 1972-04-07
SE385885B (sv) 1976-07-26
AT315856B (de) 1974-05-15
AT314540B (de) 1974-04-10
CH554346A (fr) 1974-09-30
FI55502C (fi) 1979-08-10
AT316563B (de) 1974-06-15
DE2165962A1 (de) 1972-08-31
FR2110227B1 (ja) 1975-02-07
US3707560A (en) 1972-12-26
JPS578107B2 (ja) 1982-02-15
SE7410488L (ja) 1974-08-16
DK131858C (da) 1976-02-16
AU465734B2 (en) 1975-10-09
DK131858B (da) 1975-09-15
SE390304B (sv) 1976-12-13
DE2149249A1 (de) 1972-04-13
FI55502B (fi) 1979-04-30
ES395676A1 (es) 1974-10-16

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