JPS5646884A - Novel cephamycin derivative and its preparation - Google Patents
Novel cephamycin derivative and its preparationInfo
- Publication number
- JPS5646884A JPS5646884A JP12315979A JP12315979A JPS5646884A JP S5646884 A JPS5646884 A JP S5646884A JP 12315979 A JP12315979 A JP 12315979A JP 12315979 A JP12315979 A JP 12315979A JP S5646884 A JPS5646884 A JP S5646884A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- novel
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UCKZMPLVLCKKMO-LHLIQPBNSA-N cephamycin Chemical class S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](C)[C@]21OC UCKZMPLVLCKKMO-LHLIQPBNSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal hydrogencarbonate Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound expressed by formula I (A and B are 1W5C alkylenes; x is 0 or 1; R1 is heterocylic ring or -S-heterocyclic ring).
EXAMPLE: 7 -β- ( 3D-3-Amino-3-carboxypropylthioacetamido ) -7α- methoxy-3-( 1- methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid.
USE: A remedy for bacterial diseases having a powerful antimicrobial activity against a wide range of bacteria, particularly against Gram-positive and Gram-negative bacteria.
PROCESS: A compound of formula II (Z is halogen) or a salt thereof is reacted with a compound of formula III or a salt thereof in a solvent, e.g. water, methanol or acetone, in the presence of an acid binder, e.g. an alkali metal hydrogencarbonate or pyridine, at room temperature or below to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12315979A JPS5646884A (en) | 1979-09-27 | 1979-09-27 | Novel cephamycin derivative and its preparation |
| IL58939A IL58939A (en) | 1978-12-18 | 1979-12-12 | 7 alpha-methoxycephalosporin derivatives and their production |
| AU53869/79A AU528886B2 (en) | 1978-12-18 | 1979-12-14 | 7-alpha-methoxycephalosporin derivatives |
| GB7943159A GB2040926B (en) | 1978-12-18 | 1979-12-14 | 7a - methoxysephalosporin derivative and process for producing the same |
| PT70602A PT70602A (en) | 1978-12-18 | 1979-12-17 | Process for preparing 7alpha-methoxycephalosporin derivatives |
| YU3086/79A YU41900B (en) | 1978-12-18 | 1979-12-17 | Process for obtaining the 7-alpha-methoxy - cephalosporin derivative |
| CH1114979A CH643851A5 (en) | 1978-12-18 | 1979-12-17 | 7ALPHA-METHOXYCEPHALOSPORIN DERIVATIVES AND PROCESSES FOR THEIR PREPARATION. |
| SI7913086A SI7913086A8 (en) | 1978-12-18 | 1979-12-17 | Process for obtaining the 7-alpha-methoxy-cephalosporin derivate |
| IT51101/79A IT1162424B (en) | 1978-12-18 | 1979-12-17 | DERIVATIVES OF 7 ALPHA-METOXYPHALOSPORIN AND PROCEDURE TO PRODUCE THEM |
| FR7930864A FR2444684A1 (en) | 1978-12-18 | 1979-12-17 | 7A-METHOXYCEPHALOSPORIN DERIVATIVE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME |
| SE7910387A SE446535B (en) | 1978-12-18 | 1979-12-17 | 7ALFA METOXICE PHALOSPORINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION THEREOF |
| DE2950990A DE2950990C2 (en) | 1978-12-18 | 1979-12-18 | 7? -Methoxycephalosporin derivatives, processes for their preparation and medicaments containing them |
| ES487040A ES487040A0 (en) | 1978-12-18 | 1979-12-18 | A DERIVATIVE OF 7X-METOXICEFALOSPORINA |
| GR60791A GR73909B (en) | 1978-12-18 | 1979-12-18 | |
| NLAANVRAGE7909104,A NL186161C (en) | 1978-12-18 | 1979-12-18 | PHARMACEUTICAL PREPARATION WITH ANTIBACTERIAL ACTION, AND 7BETA- (2- (SUBSTITUTED THIO) ACETAMIDO) -7ALFA-METHOXY-3- (SUBSTITUTED METHYL) -3-CEFEM-4-CARBONIC ACID DERIVATIVE. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12315979A JPS5646884A (en) | 1979-09-27 | 1979-09-27 | Novel cephamycin derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5646884A true JPS5646884A (en) | 1981-04-28 |
| JPH0154355B2 JPH0154355B2 (en) | 1989-11-17 |
Family
ID=14853635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12315979A Granted JPS5646884A (en) | 1978-12-18 | 1979-09-27 | Novel cephamycin derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5646884A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS549294A (en) * | 1977-06-22 | 1979-01-24 | Asahi Chem Ind Co Ltd | 7alpha-methoxycephalosporins and process for their preparation |
| JPS6118555A (en) * | 1984-07-05 | 1986-01-27 | 日立金属株式会社 | Welding truck for steel plate |
-
1979
- 1979-09-27 JP JP12315979A patent/JPS5646884A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS549294A (en) * | 1977-06-22 | 1979-01-24 | Asahi Chem Ind Co Ltd | 7alpha-methoxycephalosporins and process for their preparation |
| JPS6118555A (en) * | 1984-07-05 | 1986-01-27 | 日立金属株式会社 | Welding truck for steel plate |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0154355B2 (en) | 1989-11-17 |
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