JPS5651452A - Derivative of acylated indole, its preparation and blood platelet coagulation suppressing agent containing said compound as effective component - Google Patents
Derivative of acylated indole, its preparation and blood platelet coagulation suppressing agent containing said compound as effective componentInfo
- Publication number
- JPS5651452A JPS5651452A JP12672579A JP12672579A JPS5651452A JP S5651452 A JPS5651452 A JP S5651452A JP 12672579 A JP12672579 A JP 12672579A JP 12672579 A JP12672579 A JP 12672579A JP S5651452 A JPS5651452 A JP S5651452A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- derivative
- preparation
- indole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 210000001772 blood platelet Anatomy 0.000 title abstract 2
- 230000015271 coagulation Effects 0.000 title abstract 2
- 238000005345 coagulation Methods 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title abstract 2
- -1 (substituted) phenyl Chemical group 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 230000003449 preventive effect Effects 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- XYLYYSLTPSMHJR-UHFFFAOYSA-N 3-(3-benzoyl-2-methylindol-1-yl)butan-2-one Chemical compound C12=CC=CC=C2N(C(C(C)=O)C)C(C)=C1C(=O)C1=CC=CC=C1 XYLYYSLTPSMHJR-UHFFFAOYSA-N 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003527 fibrinolytic agent Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002980 postoperative effect Effects 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical class FC(F)(F)* 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:Derivatives of acylated indole of formula I [R1 is lower alkyl or (substituted) phenyl; R2 is H or lower alkyl; R3 and R4 are H, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, amino, lower alkyl-substituted amino, trifluoromethyl, etc., or R3 and R4 together form methylenedioxy or ethylenedioxy; ϕ is aryl or alicyclic group].
EXAMPLE: 3-Benzoyl-2-methyl-1-(3-oxo-2-butyl) indole.
USE: Preventive agent for cardiac vascular infarction, preventive and treatment agent for post-operative diseases, antiinflamatory agent, fibrinolytic agent etc. It has excellent activity to suppress the coagulation of blood platelets.
PROCESS: A compound of formula I is obtained by the reaction of e.g. a compound of formula II with a compound of formula III (X is halogen) in the presence of a basic compound.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12672579A JPS5651452A (en) | 1979-10-03 | 1979-10-03 | Derivative of acylated indole, its preparation and blood platelet coagulation suppressing agent containing said compound as effective component |
| DE8080302180T DE3062613D1 (en) | 1979-06-28 | 1980-06-27 | Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them |
| EP19800302180 EP0022634B1 (en) | 1979-06-28 | 1980-06-27 | Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12672579A JPS5651452A (en) | 1979-10-03 | 1979-10-03 | Derivative of acylated indole, its preparation and blood platelet coagulation suppressing agent containing said compound as effective component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5651452A true JPS5651452A (en) | 1981-05-09 |
| JPS6241499B2 JPS6241499B2 (en) | 1987-09-03 |
Family
ID=14942319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12672579A Granted JPS5651452A (en) | 1979-06-28 | 1979-10-03 | Derivative of acylated indole, its preparation and blood platelet coagulation suppressing agent containing said compound as effective component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5651452A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6487110A (en) * | 1987-09-29 | 1989-03-31 | Aizawa Tekkosho Kk | Blade part gap regulating device for shearing machine |
-
1979
- 1979-10-03 JP JP12672579A patent/JPS5651452A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6241499B2 (en) | 1987-09-03 |
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