JPS5653660A - 4-phenylphthalazine derivative - Google Patents

4-phenylphthalazine derivative

Info

Publication number
JPS5653660A
JPS5653660A JP13043479A JP13043479A JPS5653660A JP S5653660 A JPS5653660 A JP S5653660A JP 13043479 A JP13043479 A JP 13043479A JP 13043479 A JP13043479 A JP 13043479A JP S5653660 A JPS5653660 A JP S5653660A
Authority
JP
Japan
Prior art keywords
formula
compound
phenylphthalazine
infarction
cerebral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13043479A
Other languages
Japanese (ja)
Other versions
JPS6242901B2 (en
Inventor
Eisaku Hayashi
Etsuo Oishi
Yasuhiro Morinaka
Motokuni Mori
Toshimoto Kanayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Yuka Pharmaceutical Co Ltd
Original Assignee
Mitsubishi Yuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Yuka Pharmaceutical Co Ltd filed Critical Mitsubishi Yuka Pharmaceutical Co Ltd
Priority to JP13043479A priority Critical patent/JPS5653660A/en
Priority to GB8030906A priority patent/GB2063249A/en
Priority to NL8005411A priority patent/NL8005411A/en
Priority to IT25206/80A priority patent/IT1148727B/en
Priority to FR8021530A priority patent/FR2468593A1/en
Priority to DE19803038166 priority patent/DE3038166A1/en
Publication of JPS5653660A publication Critical patent/JPS5653660A/en
Publication of JPS6242901B2 publication Critical patent/JPS6242901B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (X is NH or O; R is alkyl, alkoxy, halogen, alkoxycarbonyl, cyano, hydroxyl, carboxyl, alkylcarbonyl or trifluoro- methyl; n is in integer of 1W3) and its pharmacologically permissible salt.
EXAMPLE: 1-(4-Methylanilino)-4-phenylphthalazine.
USE: An agent for suppressing coagulation of blood platelet. It is supposed to be applicable to the remedy and prophylaxis of cerebral thrombosis, cerebral infarction, cardiac infarction an arteriosclerosis.
PROCESS: The compound of formula I is prepared by reacting a comound of formula II with a compound of formula III (X' is NH2 or OH) in the presence or absence of solvent, pref. in the presence of a catalyst such as ammonia, triethylamine, Na2CO3, NaOH, Mg, Na, etc., at -10W+180°C for 10min to 10hr.
COPYRIGHT: (C)1981,JPO&Japio
JP13043479A 1979-10-09 1979-10-09 4-phenylphthalazine derivative Granted JPS5653660A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP13043479A JPS5653660A (en) 1979-10-09 1979-10-09 4-phenylphthalazine derivative
GB8030906A GB2063249A (en) 1979-10-09 1980-09-25 4-Phenylphthalazine derivatives
NL8005411A NL8005411A (en) 1979-10-09 1980-09-30 4-PHENYLFTALAZINE DERIVATIVES.
IT25206/80A IT1148727B (en) 1979-10-09 1980-10-08 THERAPEUTIC ACTION 4-FENYL-PHTALAZINE DERIVATIVES
FR8021530A FR2468593A1 (en) 1979-10-09 1980-10-08 4-PHENYLPHTALAZINE DERIVATIVES AS INHIBITORY DRUGS IN THE AGGREGATION OF BLOOD PLAQUETTES, AND PROCESS FOR THEIR PREPARATION
DE19803038166 DE3038166A1 (en) 1979-10-09 1980-10-09 4-PHENYLPHTHALAZINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13043479A JPS5653660A (en) 1979-10-09 1979-10-09 4-phenylphthalazine derivative

Publications (2)

Publication Number Publication Date
JPS5653660A true JPS5653660A (en) 1981-05-13
JPS6242901B2 JPS6242901B2 (en) 1987-09-10

Family

ID=15034137

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13043479A Granted JPS5653660A (en) 1979-10-09 1979-10-09 4-phenylphthalazine derivative

Country Status (1)

Country Link
JP (1) JPS5653660A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324727A (en) * 1991-09-26 1994-06-28 Mitsubishi Chem Ind 3,6-disubstituted pyridazine derivatives
EP0682947A1 (en) 1994-05-19 1995-11-22 Mitsubishi Chemical Corporation Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324727A (en) * 1991-09-26 1994-06-28 Mitsubishi Chem Ind 3,6-disubstituted pyridazine derivatives
US5462941A (en) * 1991-09-26 1995-10-31 Mitsubishi Chemical Corporation 3,6-disubstituted pyradazine derivatives
EP0682947A1 (en) 1994-05-19 1995-11-22 Mitsubishi Chemical Corporation Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia

Also Published As

Publication number Publication date
JPS6242901B2 (en) 1987-09-10

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