JPS5673069A - Pyrazolecarboxylic acid derivative - Google Patents
Pyrazolecarboxylic acid derivativeInfo
- Publication number
- JPS5673069A JPS5673069A JP14909979A JP14909979A JPS5673069A JP S5673069 A JPS5673069 A JP S5673069A JP 14909979 A JP14909979 A JP 14909979A JP 14909979 A JP14909979 A JP 14909979A JP S5673069 A JPS5673069 A JP S5673069A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- methyl
- acid derivative
- phenyl
- pyrazolecarboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KOPFEFZSAMLEHK-UHFFFAOYSA-N 1h-pyrazole-5-carboxylic acid Chemical class OC(=O)C=1C=CNN=1 KOPFEFZSAMLEHK-UHFFFAOYSA-N 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- JLHCQGQSDULOAV-UHFFFAOYSA-N 1-methyl-5-nonylpyrazole-3-carboxylic acid Chemical compound CCCCCCCCCC1=CC(C(O)=O)=NN1C JLHCQGQSDULOAV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002402 anti-lipaemic effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- -1 monosubstituted hydrazine sulfate Chemical class 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A pyrazolecarboxylic acid derivative expressed by formula I [R1 is straight chain alkyl of CnH2n+1 (n is an integer 1W13); R2 is methyl or phenyl].
EXAMPLE: 1-Methyl-5-n-nonylpyrazole-3-carboxylic acid.
USE: A medicine having improved antilipemic action with low toxicity.
PROCESS: An enolate sodium salt of formula II and a monosubstituted hydrazine sulfate of formula III (m is 1 when R2 is methyl, and 2 when R2 is phenyl) are dissolved in purified water or methanol, and the solution is heated in aqueous solution of NaOH for 1W2hr to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14909979A JPS5673069A (en) | 1979-11-16 | 1979-11-16 | Pyrazolecarboxylic acid derivative |
| ES497143A ES497143A0 (en) | 1979-11-16 | 1980-11-13 | PROCEDURE FOR THE MANUFACTURE OF PYRAZOLE DERIVATIVES |
| EP19800304106 EP0029363A1 (en) | 1979-11-16 | 1980-11-14 | Pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14909979A JPS5673069A (en) | 1979-11-16 | 1979-11-16 | Pyrazolecarboxylic acid derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5673069A true JPS5673069A (en) | 1981-06-17 |
Family
ID=15467668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14909979A Pending JPS5673069A (en) | 1979-11-16 | 1979-11-16 | Pyrazolecarboxylic acid derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5673069A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002523401A (en) * | 1998-08-17 | 2002-07-30 | バイエル アクチェンゲゼルシャフト | Method for producing 1-alkyl-pyrazole-5-carboxylic acid ester III |
| KR100352924B1 (en) * | 1999-06-18 | 2002-09-16 | 미쯔이카가쿠 가부시기가이샤 | 5-aminopyrazole-4-carboxylate derivative and process for preparing the same |
-
1979
- 1979-11-16 JP JP14909979A patent/JPS5673069A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002523401A (en) * | 1998-08-17 | 2002-07-30 | バイエル アクチェンゲゼルシャフト | Method for producing 1-alkyl-pyrazole-5-carboxylic acid ester III |
| KR100352924B1 (en) * | 1999-06-18 | 2002-09-16 | 미쯔이카가쿠 가부시기가이샤 | 5-aminopyrazole-4-carboxylate derivative and process for preparing the same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5692859A (en) | Preparation of hydroxyalkylaminosulfnonic acid | |
| JPS57142962A (en) | Cyclodextrin clathrate compound of sulfur-containing compound | |
| JPS5791997A (en) | 5'-o-acylnucleoside and its preparation | |
| JPS5673069A (en) | Pyrazolecarboxylic acid derivative | |
| JPS5631492A (en) | Stabilization of residual chlorine | |
| JPS574997A (en) | Platina compound and its drug composition | |
| JPS5740496A (en) | Low toxic derivative of istamycin antibiotic | |
| JPS54112873A (en) | Preparation of 2,2,6,6-tetramethyl-4-oxopiperidine | |
| JPS5716852A (en) | Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same | |
| JPS5732260A (en) | Mercaptofatty acid derivative and its preparation | |
| JPS5663991A (en) | Glucosamine derivative and its preparation | |
| JPS53132584A (en) | 18-cyano-18-substituted amino-18-deoxy-macrolide anibiotic substance derivative | |
| JPS56127378A (en) | 2-alkoxyindolizine derivative and its preparation | |
| JPS5455562A (en) | Lactam compound | |
| JPS5671081A (en) | Thiazolinedicarboxylic acid derivative | |
| JPS57193466A (en) | Novel 1,2,4-triazole derivative | |
| JPS5721400A (en) | Novel fortimicin derivative | |
| JPS5673070A (en) | Pyrazolecarboxylic acid derivative | |
| JPS5721321A (en) | Antihyperlipemic agent | |
| JPS5639080A (en) | Benzisothiazole derivative | |
| JPS5714597A (en) | K-41 derivative | |
| JPS56158786A (en) | Novel camptothecin derivative and its preparation | |
| JPS5759856A (en) | Benzene derivative | |
| IE43426L (en) | Ureidoacetic acid fungicides. | |
| JPS5538301A (en) | New derivative of antibiotics fortimicin and its preparation |