JPS567765A - 4,4'-methylenebis-(1-substituted-3-phenylamino-5-oxo-3,4-dehydropiperidine) derivative - Google Patents
4,4'-methylenebis-(1-substituted-3-phenylamino-5-oxo-3,4-dehydropiperidine) derivativeInfo
- Publication number
- JPS567765A JPS567765A JP8322479A JP8322479A JPS567765A JP S567765 A JPS567765 A JP S567765A JP 8322479 A JP8322479 A JP 8322479A JP 8322479 A JP8322479 A JP 8322479A JP S567765 A JPS567765 A JP S567765A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- phenylamino
- oxo
- derivative
- dehydropiperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- KIBFBTVPDRASNT-UHFFFAOYSA-N piperidine-3,5-dione Chemical class O=C1CNCC(=O)C1 KIBFBTVPDRASNT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound and its salt of formula I (R is phenylalkyl, lower alkanoyl, lower alkoxycarbonyl, lower alkanesulfonyl, or phenylsulfonyl which may have lower alkyl as a substitution group).
EXAMPLE: 4,4'-Methylene-bis-(1-benzyl-3-phenylamino-5-oxo-3,4-dehydro-piperidine).
USE: An analgesic, sedative, tranquillizer, antipyretic, antispasmodic, remedy for diabetes, and antiphlogistic.
PROCESS: The compound of formula I is prepared, for example, by reacting a piperidine-3,5-dione derivative of formula II with aniline in a proper solvent at 50W100°C, and then heating and reacting the resulting compound of formula III with formaldehyde in a proper solvent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8322479A JPS567765A (en) | 1979-06-29 | 1979-06-29 | 4,4'-methylenebis-(1-substituted-3-phenylamino-5-oxo-3,4-dehydropiperidine) derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8322479A JPS567765A (en) | 1979-06-29 | 1979-06-29 | 4,4'-methylenebis-(1-substituted-3-phenylamino-5-oxo-3,4-dehydropiperidine) derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS567765A true JPS567765A (en) | 1981-01-27 |
| JPS6125710B2 JPS6125710B2 (en) | 1986-06-17 |
Family
ID=13796338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8322479A Granted JPS567765A (en) | 1979-06-29 | 1979-06-29 | 4,4'-methylenebis-(1-substituted-3-phenylamino-5-oxo-3,4-dehydropiperidine) derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS567765A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758575A (en) * | 1985-02-22 | 1988-07-19 | Ciba-Geigy Corporation | Bi-2H-pyrroli(di)nediones |
-
1979
- 1979-06-29 JP JP8322479A patent/JPS567765A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758575A (en) * | 1985-02-22 | 1988-07-19 | Ciba-Geigy Corporation | Bi-2H-pyrroli(di)nediones |
| US4789674A (en) * | 1985-02-22 | 1988-12-06 | Ciba-Geigy Corporation | Bi-2H-pyrroli(di)nediones |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6125710B2 (en) | 1986-06-17 |
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