JPS567800A - 9alpha-hydroxysteroid - Google Patents
9alpha-hydroxysteroidInfo
- Publication number
- JPS567800A JPS567800A JP8362879A JP8362879A JPS567800A JP S567800 A JPS567800 A JP S567800A JP 8362879 A JP8362879 A JP 8362879A JP 8362879 A JP8362879 A JP 8362879A JP S567800 A JPS567800 A JP S567800A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- oil
- sterol
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930182558 Sterol Natural products 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003432 sterols Chemical class 0.000 abstract 3
- 235000003702 sterols Nutrition 0.000 abstract 3
- 239000003921 oil Substances 0.000 abstract 2
- 235000019198 oils Nutrition 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000186359 Mycobacterium Species 0.000 abstract 1
- 241000316848 Rhodococcus <scale insect> Species 0.000 abstract 1
- 241000158504 Rhodococcus hoagii Species 0.000 abstract 1
- 241000238371 Sepiidae Species 0.000 abstract 1
- 239000003470 adrenal cortex hormone Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 abstract 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 235000021323 fish oil Nutrition 0.000 abstract 1
- 229960001067 hydrocortisone acetate Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000005445 natural material Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
NEW MATERIAL:A 9α-hydroxy-3-oxopregna-4, 17(20)-diene-20-carboxylic acid methyl ester shown by the formula I.
USE: A synthetic intermediate for corticoid. For example, hydrocortisone acetate, predonisolone, etc. can be synthesized from a low-priced sterol as a starting material.
PROCESS: For example, a bacterium (e.g., belonging to the genus Rhodococcus, the genus R. equi ATCC21329) capable of introducing OH into 9α position is fermented using a compound shown by the formula II as a substrate to give a compound shown by the formula I. The fermentation is carried out by aerobic liquid cultivation. The compound shown by the formula II, for example, is obtained by fermenting Mycobacterium species NRRLB-8054 using various kinds of sterols as a substrate. A sterol-containing natural substance, e.g., dark oil obtained by cleaning fish oil and cuttlefish oil with an alkali, deodorized scrum of vegetable oil, etc. may be used as the raw material.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8362879A JPS567800A (en) | 1979-07-02 | 1979-07-02 | 9alpha-hydroxysteroid |
| US06/085,639 US4255344A (en) | 1978-11-08 | 1979-10-17 | 9-α-Hydroxy steroids |
| EP79104372A EP0011235B1 (en) | 1978-11-08 | 1979-11-07 | 9-alpha-hydroxy-3-oxopregna-4,17(20)-diene-20-carboxylic acid and its methyl ester and methods for the microbiological production thereof |
| DE7979104372T DE2963189D1 (en) | 1978-11-08 | 1979-11-07 | 9-alpha-hydroxy-3-oxopregna-4,17(20)-diene-20-carboxylic acid and its methyl ester and methods for the microbiological production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8362879A JPS567800A (en) | 1979-07-02 | 1979-07-02 | 9alpha-hydroxysteroid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS567800A true JPS567800A (en) | 1981-01-27 |
| JPS6159639B2 JPS6159639B2 (en) | 1986-12-17 |
Family
ID=13807728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8362879A Granted JPS567800A (en) | 1978-11-08 | 1979-07-02 | 9alpha-hydroxysteroid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS567800A (en) |
-
1979
- 1979-07-02 JP JP8362879A patent/JPS567800A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6159639B2 (en) | 1986-12-17 |
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