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RIKEN
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RIKEN
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Application filed by RIKENfiledCriticalRIKEN
Priority to JP11814380ApriorityCriticalpatent/JPS5914476B2/en
Publication of JPS5742696ApublicationCriticalpatent/JPS5742696A/en
Publication of JPS5914476B2publicationCriticalpatent/JPS5914476B2/en
USE: A substance for inducing nephritis and useful to obtain diseased animals.
PROCESS: The compound of formula I is prepared by the following successive steps: conversion of the tetra-O-acetyl-β-D-glucopyranosyl halide of formula II (Ac is acetyl; X is halogen) to azide compound, removal of acetyl groups, tritylation, re- acetylation, removal of trityl groups, reaction of the product with tetra-O-acetyl-α- D-glucopyranosyl halode of formula III, removal of acetyl group, tritylation, re- acetylation, removal of trityl group to obtain the compound of formula IV (R2 is H or trityl), reaction of the compound of formula IV with tetra-O-benzyl-α-D-glucopyranosyl halide, conversion of the product to azide compound, hydrolysis, removal of acetyl group, benzylation, hydrogenation, reaction of the product with the compound of formula V (Bn is benzyl), and catalytic reduction with hydrogen.
COPYRIGHT: (C)1982,JPO&Japio
JP11814380A1980-08-271980-08-27
Synthesis method of novel glycopeptides
ExpiredJPS5914476B2
(en)
Delta-1,3,5-3-chloro-11 beta, 16 alpha, 17 alpha, 21-tetrahydroxy-pregnan-20-one-16,17-acetonide derivatives, process for their preparation and pharmaceutical preparations containing them
2'-substituted-spiro(benzofuran-2(3h),1'-cycloalkanes)and intermediates thereof,a process for preparing same,pharmaceutical compositions containing such compounds and their use as medicaments