JPS5758886A - Preparation of immobilized physiologically active substance - Google Patents
Preparation of immobilized physiologically active substanceInfo
- Publication number
- JPS5758886A JPS5758886A JP13480380A JP13480380A JPS5758886A JP S5758886 A JPS5758886 A JP S5758886A JP 13480380 A JP13480380 A JP 13480380A JP 13480380 A JP13480380 A JP 13480380A JP S5758886 A JPS5758886 A JP S5758886A
- Authority
- JP
- Japan
- Prior art keywords
- active substance
- physiologically active
- copolymer
- vinyl acetate
- aminated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013543 active substance Substances 0.000 title abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 3
- 229920001577 copolymer Polymers 0.000 abstract 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical group CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 abstract 2
- 239000005038 ethylene vinyl acetate Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 abstract 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 abstract 1
- BXRFQSNOROATLV-UHFFFAOYSA-N 4-nitrobenzaldehyde Chemical compound [O-][N+](=O)C1=CC=C(C=O)C=C1 BXRFQSNOROATLV-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000005515 coenzyme Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003100 immobilizing effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Landscapes
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
PURPOSE: To prepare an immobilized physiologically active substance usable preferably in an aqueous medium and an organic solvent, having improved moldability, by aminating an ethylene-vinyl acetate copolymer, followed by immobilizing a physiologically active substance to the aminated copolymer by a covalent bond.
CONSTITUTION: An ethylene-vinyl acetate copolymer comprising 20W97wt%, preferably 40W95wt% vinyl acetate unit, having ≥80mol% saponified vinyl acetate unit, is reacted with an aminating agent containing a functional group capable of reacting with the hydroxyl group of the copolymer and an amino group or nitro group, e.g., P-nitrobenzaldehyde, γ-aminopropyltriethoxysilane, etc. The existing nitro group is reduced into an amino group to prepare an aminated polymer, and a physiologically active substance, e.g., enzyme, coenzyme, hormone, etc. is linked to the aminated copolymer through the amino group by a covalent bond.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13480380A JPS5758886A (en) | 1980-09-26 | 1980-09-26 | Preparation of immobilized physiologically active substance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13480380A JPS5758886A (en) | 1980-09-26 | 1980-09-26 | Preparation of immobilized physiologically active substance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5758886A true JPS5758886A (en) | 1982-04-08 |
| JPS5759759B2 JPS5759759B2 (en) | 1982-12-16 |
Family
ID=15136889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13480380A Granted JPS5758886A (en) | 1980-09-26 | 1980-09-26 | Preparation of immobilized physiologically active substance |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5758886A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59191166U (en) * | 1983-06-06 | 1984-12-18 | 株式会社 福島製作所 | Angular position detection device for trawl winch seine control |
| JPS60161443A (en) * | 1984-01-17 | 1985-08-23 | レ・カーブル・ドウ・リヨン | Refractory thermoplastic resin composition |
-
1980
- 1980-09-26 JP JP13480380A patent/JPS5758886A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59191166U (en) * | 1983-06-06 | 1984-12-18 | 株式会社 福島製作所 | Angular position detection device for trawl winch seine control |
| JPS60161443A (en) * | 1984-01-17 | 1985-08-23 | レ・カーブル・ドウ・リヨン | Refractory thermoplastic resin composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5759759B2 (en) | 1982-12-16 |
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