JPS5767520A - Preparation of antitumor agent - Google Patents
Preparation of antitumor agentInfo
- Publication number
- JPS5767520A JPS5767520A JP55142578A JP14257880A JPS5767520A JP S5767520 A JPS5767520 A JP S5767520A JP 55142578 A JP55142578 A JP 55142578A JP 14257880 A JP14257880 A JP 14257880A JP S5767520 A JPS5767520 A JP S5767520A
- Authority
- JP
- Japan
- Prior art keywords
- water
- fraction
- raw material
- antitumor agent
- precipitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
- 239000002994 raw material Substances 0.000 abstract 3
- 102000006395 Globulins Human genes 0.000 abstract 2
- 108010044091 Globulins Proteins 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000010257 thawing Methods 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare an antitumor agent containing a globulin fraction insoluble in cold water as a main component, by using human blood or its fraction as a raw material, and repeating the steps comprising freezing, thawing recovery of precipitate by centrifugation under cooling, and dissolution in warm aqueous solution.
CONSTITUTION: Human blood (added with heparin) or its fraction is used as the raw material. After removing solid components, the raw material is frozen, thawed at room tepm. or in water, and separated by centrifugal separator under cooling at 0W4°C. The precipitate is collected, and dissolved in warm water of 10W40°C. The water pref. contains a tripsin-inhibitor, an anticoagulant, and bivalent ions. The solution is again frozen, and the above procedures are repeated at least once more to obtain an antitumor agent containing a globulin fraction which is insoluble in cold water, as a main component.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55142578A JPS5767520A (en) | 1980-10-13 | 1980-10-13 | Preparation of antitumor agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55142578A JPS5767520A (en) | 1980-10-13 | 1980-10-13 | Preparation of antitumor agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5767520A true JPS5767520A (en) | 1982-04-24 |
Family
ID=15318566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55142578A Pending JPS5767520A (en) | 1980-10-13 | 1980-10-13 | Preparation of antitumor agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5767520A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59206312A (en) * | 1983-04-28 | 1984-11-22 | ア−マ− フア−マシユ−テイカル カンパニ− | Pharmaceutical blend containing purified fibronectin |
-
1980
- 1980-10-13 JP JP55142578A patent/JPS5767520A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59206312A (en) * | 1983-04-28 | 1984-11-22 | ア−マ− フア−マシユ−テイカル カンパニ− | Pharmaceutical blend containing purified fibronectin |
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