JPS5777687A - Novel preparation of 2-chloro-3,4-dihydrothieno(2,3-d) pyrimidine compound - Google Patents
Novel preparation of 2-chloro-3,4-dihydrothieno(2,3-d) pyrimidine compoundInfo
- Publication number
- JPS5777687A JPS5777687A JP15494980A JP15494980A JPS5777687A JP S5777687 A JPS5777687 A JP S5777687A JP 15494980 A JP15494980 A JP 15494980A JP 15494980 A JP15494980 A JP 15494980A JP S5777687 A JPS5777687 A JP S5777687A
- Authority
- JP
- Japan
- Prior art keywords
- boron hydride
- compound shown
- compound
- novel
- dihydrothieno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 2-chloro-3,4-dihydrothieno(2,3-d) pyrimidine compound Chemical class 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 229910010277 boron hydride Inorganic materials 0.000 abstract 2
- MOOAHMCRPCTRLV-UHFFFAOYSA-N boron sodium Chemical compound [B].[Na] MOOAHMCRPCTRLV-UHFFFAOYSA-N 0.000 abstract 2
- VCJCJLZVNOZZLS-UHFFFAOYSA-N [1]benzothiolo[2,3-d]pyrimidine Chemical compound C1=NC=C2C3=CC=CC=C3SC2=N1 VCJCJLZVNOZZLS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- PPTSBERGOGHCHC-UHFFFAOYSA-N boron lithium Chemical compound [Li].[B] PPTSBERGOGHCHC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- KUDPGZONDFORKU-UHFFFAOYSA-N n-chloroaniline Chemical compound ClNC1=CC=CC=C1 KUDPGZONDFORKU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as an intermediate for a compound having an inhibiting action on blood platelet aggregation, by reacting a novel pyrimidine compound with an alkali metal boron hydride.
CONSTITUTION: A novel compound shown by the formulaI(R 1 and R2 are H, alkyl, halogen, etc.) is reacted with an alkali metal boron hydride (e.g., sodium boron hydride, lithium boron hydride) to give the desired compound shown by the formula II. The compound shown by the formulaIis in a solvent (e.g., methanol, ethanol) in the reaction which is carried out at room temperature W about 60°C for 1W20hr. For the novel compound shown by the formulaI, for example, 2,4-dichloro- 5,6,7,8-teterahydro[1]benzothieno[2,3-d]pyrimidine is reacted with sodium boron hydride and with chloroaniline in benzene, to give a compound shown by the formulaIwherein R1=R2=H.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15494980A JPS5777687A (en) | 1980-11-04 | 1980-11-04 | Novel preparation of 2-chloro-3,4-dihydrothieno(2,3-d) pyrimidine compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15494980A JPS5777687A (en) | 1980-11-04 | 1980-11-04 | Novel preparation of 2-chloro-3,4-dihydrothieno(2,3-d) pyrimidine compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5777687A true JPS5777687A (en) | 1982-05-15 |
Family
ID=15595433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15494980A Pending JPS5777687A (en) | 1980-11-04 | 1980-11-04 | Novel preparation of 2-chloro-3,4-dihydrothieno(2,3-d) pyrimidine compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5777687A (en) |
-
1980
- 1980-11-04 JP JP15494980A patent/JPS5777687A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5795964A (en) | Preparation of 2-substituted-3(2h)-pyridazinone derivative | |
| JPS56104890A (en) | Preparation of organosilane | |
| JPS5777687A (en) | Novel preparation of 2-chloro-3,4-dihydrothieno(2,3-d) pyrimidine compound | |
| JPS57136581A (en) | Preparation of 1,5-benzothiazepin derivative | |
| JPS57175186A (en) | Novel vitamin e derivative and its preparation | |
| JPS52285A (en) | Preparation of n1 *22tetrahydrofuryl**55fluorouracil | |
| JPS55122785A (en) | Preparation of benzopyranopyridine derivative | |
| JPS56118081A (en) | Preparation of 6-methoxy-1,8-naphthyridine | |
| JPS53141205A (en) | Preparation of 3,7-dimethyl-2,6-octadienylamine derivatives | |
| JPS527994A (en) | Process for preparing novel pyrimido (4,5-d) pyrimidine derivatives | |
| JPS56100786A (en) | 1-azaerythrinan derivative | |
| JPS55164682A (en) | 1-alkyl-2-oxo-2h-1,8-naphthyridine derivative and its preparation | |
| JPS5436274A (en) | Preparation of propiophenone derivative | |
| JPS56139486A (en) | Pyrano 2,3-b indolizine derivative and its preparation | |
| JPS51143697A (en) | A process for preparing novel pyrimido (4,5-d) pyrimidine derivatives | |
| JPS5353695A (en) | Preparation of pyrimido 5,4-d pyrimidine derivatives | |
| JPS56131588A (en) | Preparation of furo(3,2-b)(1,8)naphthyridine-7-carboxylic acid | |
| JPS5547651A (en) | Production of sulfoxyimine | |
| JPS55102561A (en) | 2-aroylformyl-substituted pyrrole derivative and its preparation | |
| JPS55136293A (en) | Thiazolo 3,2-a pyrimidine derivative and its preparation | |
| JPS56125386A (en) | Pyrido (2,3-d)pyrimidine derivative and its preparation | |
| JPS5742652A (en) | Preparation of hydroxyphenylacetic acid and catalyst for preparing it | |
| JPS52144696A (en) | Novel pyrido (2,3-d) pyprole (1,2-a) pyrimidine derivatives | |
| JPS5750967A (en) | Preparation of 1-alkyl-3-methylpyrazole compound | |
| JPS55120590A (en) | Preparation of gamma-amino-gamma-carboxypropyl-methylphosphinic acid |