JPS579760A - Novel isothiourea derivative and its preparation - Google Patents

Novel isothiourea derivative and its preparation

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Publication number
JPS579760A
JPS579760A JP8553180A JP8553180A JPS579760A JP S579760 A JPS579760 A JP S579760A JP 8553180 A JP8553180 A JP 8553180A JP 8553180 A JP8553180 A JP 8553180A JP S579760 A JPS579760 A JP S579760A
Authority
JP
Japan
Prior art keywords
formula
preparation
derivative
prepared
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8553180A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Giichi Funatsukuri
Toshimitsu Shigeari
Koichi Seki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP8553180A priority Critical patent/JPS579760A/en
Publication of JPS579760A publication Critical patent/JPS579760A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:An isothiourea derivative of formula I (R is hydroxy group or chlorine).
EXAMPLE: N-Cyano-N'-(2-chloroethyl)-S-methyl isothiourea.
USE: Useful as an intermediate for the preparation of cimetidine which blocks histamine H2-receptor and has the remedying activity to gastric ulcer, duodenal ulcer, etc. The compound can be prepared from aminoethanol and chloroethylamine which are easily available in the market, and accordingly it has excellent industrial value.
PROCESS: The compound of formula I is prepared by reacting an ethylamine derivative of formula II with dimethylcyanoimide dithiocarbonate of formula III in a polar solvent at a temperature between room temperature and 110°C for 0.5W5 hours. The polar solvent is selected from those which do not directly concern with the reaction, e.g. alcohols.
COPYRIGHT: (C)1982,JPO&Japio
JP8553180A 1980-06-23 1980-06-23 Novel isothiourea derivative and its preparation Pending JPS579760A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8553180A JPS579760A (en) 1980-06-23 1980-06-23 Novel isothiourea derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8553180A JPS579760A (en) 1980-06-23 1980-06-23 Novel isothiourea derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS579760A true JPS579760A (en) 1982-01-19

Family

ID=13861465

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8553180A Pending JPS579760A (en) 1980-06-23 1980-06-23 Novel isothiourea derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS579760A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6359938U (en) * 1986-10-07 1988-04-21

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6359938U (en) * 1986-10-07 1988-04-21

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