JPS579760A - Novel isothiourea derivative and its preparation - Google Patents
Novel isothiourea derivative and its preparationInfo
- Publication number
- JPS579760A JPS579760A JP8553180A JP8553180A JPS579760A JP S579760 A JPS579760 A JP S579760A JP 8553180 A JP8553180 A JP 8553180A JP 8553180 A JP8553180 A JP 8553180A JP S579760 A JPS579760 A JP S579760A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- derivative
- prepared
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002541 isothioureas Chemical class 0.000 title abstract 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002798 polar solvent Substances 0.000 abstract 2
- BGPJLYIFDLICMR-UHFFFAOYSA-N 1,4,2,3-dioxadithiolan-5-one Chemical compound O=C1OSSO1 BGPJLYIFDLICMR-UHFFFAOYSA-N 0.000 abstract 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- VKPPFDPXZWFDFA-UHFFFAOYSA-N 2-chloroethanamine Chemical compound NCCCl VKPPFDPXZWFDFA-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 abstract 1
- 229960001380 cimetidine Drugs 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000003947 ethylamines Chemical class 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- ZKQQMKNGNIZFET-UHFFFAOYSA-N methyl n'-(2-chloroethyl)-n-cyanocarbamimidothioate Chemical compound N#CNC(SC)=NCCCl ZKQQMKNGNIZFET-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:An isothiourea derivative of formula I (R is hydroxy group or chlorine).
EXAMPLE: N-Cyano-N'-(2-chloroethyl)-S-methyl isothiourea.
USE: Useful as an intermediate for the preparation of cimetidine which blocks histamine H2-receptor and has the remedying activity to gastric ulcer, duodenal ulcer, etc. The compound can be prepared from aminoethanol and chloroethylamine which are easily available in the market, and accordingly it has excellent industrial value.
PROCESS: The compound of formula I is prepared by reacting an ethylamine derivative of formula II with dimethylcyanoimide dithiocarbonate of formula III in a polar solvent at a temperature between room temperature and 110°C for 0.5W5 hours. The polar solvent is selected from those which do not directly concern with the reaction, e.g. alcohols.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8553180A JPS579760A (en) | 1980-06-23 | 1980-06-23 | Novel isothiourea derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8553180A JPS579760A (en) | 1980-06-23 | 1980-06-23 | Novel isothiourea derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS579760A true JPS579760A (en) | 1982-01-19 |
Family
ID=13861465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8553180A Pending JPS579760A (en) | 1980-06-23 | 1980-06-23 | Novel isothiourea derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS579760A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6359938U (en) * | 1986-10-07 | 1988-04-21 |
-
1980
- 1980-06-23 JP JP8553180A patent/JPS579760A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6359938U (en) * | 1986-10-07 | 1988-04-21 |
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