JPS5728056A - Dihydropyridazinone derivative - Google Patents
Dihydropyridazinone derivativeInfo
- Publication number
- JPS5728056A JPS5728056A JP10536380A JP10536380A JPS5728056A JP S5728056 A JPS5728056 A JP S5728056A JP 10536380 A JP10536380 A JP 10536380A JP 10536380 A JP10536380 A JP 10536380A JP S5728056 A JPS5728056 A JP S5728056A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- lower alkyl
- reacted
- dihydropyridazinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SSDAKJLEKSSAMH-UHFFFAOYSA-N 2,4-dihydro-1h-pyridazin-3-one Chemical class O=C1CC=CNN1 SSDAKJLEKSSAMH-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010020601 Hyperchlorhydria Diseases 0.000 abstract 1
- -1 N-Cyano-N'-[ 4-( 4,5-dihydro-6-phenyl-3-oxo-2-pyridazinyl )butyl ]-N"- methylguanidine Chemical compound 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- IULFXBLVJIPESI-UHFFFAOYSA-N bis(methylsulfanyl)methylidenecyanamide Chemical compound CSC(SC)=NC#N IULFXBLVJIPESI-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 150000002541 isothioureas Chemical class 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A dihydropyridazinone derivative of formula I (R1, R2 and R3 are H, halogen, lower alkyl or lower alkyloxy; R4 and R5 are H or lower alkyl; R6 is lower alkyl; m is an integer 1W5).
EXAMPLE: N-Cyano-N'-[ 4-( 4,5-dihydro-6-phenyl-3-oxo-2-pyridazinyl )butyl ]-N"- methylguanidine.
USE: Useful as a remedy and a preventing agent against peptic ulcers, e.g. gastric hyperacidity, gastric ulcer or duodenal ulcer, and having great prolonged action, low toxicity and improved chemical resistance.
PROCESS: An amine derivative of formula II is reacted with dimethyl cyanodithioimidocarbonate in the absence or presence of an inert solvent, e.g. ethanol, at room temperature or under cooling to give an isothiourea derivative of formula III, which is then reacted with an amide derivative of formula IV under heating to afford the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10536380A JPS5728056A (en) | 1980-07-29 | 1980-07-29 | Dihydropyridazinone derivative |
| EP19800304409 EP0030835B1 (en) | 1979-12-05 | 1980-12-05 | Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them |
| DE8080304409T DE3063196D1 (en) | 1979-12-05 | 1980-12-05 | Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10536380A JPS5728056A (en) | 1980-07-29 | 1980-07-29 | Dihydropyridazinone derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5728056A true JPS5728056A (en) | 1982-02-15 |
Family
ID=14405637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10536380A Pending JPS5728056A (en) | 1979-12-05 | 1980-07-29 | Dihydropyridazinone derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5728056A (en) |
-
1980
- 1980-07-29 JP JP10536380A patent/JPS5728056A/en active Pending
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