JPS583631A - Water-in-oil type emulsion - Google Patents

Abstract

PURPOSE:To obtain a water-in-oil type emulsion having shelf life stability, dynamic stability and good feeling, by compounding a specific fatty acid ester of a trihydric alcohol and a carboxyvinyl polymer as emulsifiers in a specific ratio. CONSTITUTION:As emulsifiers, 1pt.wts monoester of a trihydric alcohol with an 8C or higher fatty acid, which is a liquid or a flowable paste at a room temp., such as glycerol monooleate, and 0.03-1pt.wt. carboxyvinyl polymer are compounded. A water-in-oil type emulsion prepared by using the obtained emulsifier composition has good shelf life stability and dynamic stability as well as is rich in compatibility with skin and shows a refreshing effect to skin.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to water-in-oil emulsions, and in particular to stable water-in-oil emulsion systems useful in the cosmetic and pharmaceutical formulation fields, which are unexpected in emulsion systems. Using a unique combination of emulsifiers that provides a degree of stability,
IIJ9 s This relates to a water-in-oil emulsion bottle that makes it possible to disperse a high percentage of the internal water phase in the external phase.

Conventionally, as a base for creams, etc., so-called water-in-oil emulsions, which contain water particles neutralized with general oil, have been used as bases for creams, etc. Compared to oil-in-water emulsion.

It is generally recognized that it is excellent in many respects, such as providing skin protection and flexibility. but,
There are several problems with the stability of the water-in-oil emulsion W7F1, and efforts are being made to improve the stability by increasing the amount of oil and increasing the viscosity. However, as a result, the feel of the emulsion is impaired and the emulsion becomes unnecessarily sticky or oily, which tends to be disliked by consumers. In order to improve these points, attempts have been made to reduce the amount of oil used in the seasonings and to use oil components that are less oily, but all of these methods have problems with stability, elegance of appearance, and use. There remains a problem with the sense of
At present, satisfactory results have not been obtained.

The need for water-in-oil emulsions with high aqueous phase content has been desired for cosmetics such as lotions in creams, toiletry products, and medicinal preparations. Water-in-oil type industrial multiw7 Base or carrier WSt is extremely difficult (9).Especially oils intended for cosmetics and medicinal preparations containing water-soluble active ingredients and drug ingredients. Although it has many advantages, the kernels that give high aqueous phase content to Nakamizuya emulsions etc. can be added to such emulsions by approximately 5° without affecting the shelf life or stability of the product. It was impossible to incorporate more water.

In this regard, because there is a large time lag between product manufacture and sale, short-term interactions may be a problem, especially when exposed to high or low temperatures that may be encountered during transportation or storage. It is not a good idea to use an emulsion pace that would destroy the emulsion.

We must maintain stability without any problems.

Water-in-oil emulsion bases are used in barrier products to cover the skin Wi with a thin oil film and medicinal preparations for closing skin openings. As the water content in the emulsion increases, the oily feel is reduced without compromising the overall usefulness of the formulation, and this high water content accelerates evaporation, resulting in cream and Food products formulated with the emulsifier composition according to the present invention have a less greasy feel when applied than conventional products, which has a more favorable appeal to users in terms of enhancing the cooling effect of the roan ron. This type of product has an excellent cooling sensation and has the required emollient properties and skin occlusive properties.

This time, the requirements required to obtain water-in-oil emulsion mushrooms)
ILB! By using nine types of water-soluble water-absorbing polymeric substances with relative compatibility with the lipophilic emulsifier ↓ seconds selected, water-in-oil molding can absorb a larger amount of water than expected! It turns out that it can be added to Luji's diet.

The water-in-oil emulsion according to the present invention is not only useful as a cosmetic base, but can also be particularly effectively used in medicinal formulation compositions such as topical ointments. For example, taking advantage of the high water content, salt, urea, and other water-soluble medicinal ingredients can be added without compromising the stability of the base.

As described above, the present invention provides a water-in-oil emulsion that has storage stability and dynamic stability, is highly homogeneous to the skin, and provides a light texture upon use.

In preparing the water-in-oil dishwashing liquid of the present invention, the emulsifiers used are (1) a fatty acid ester of a trihydric alcohol that is liquid at room temperature and exhibits a pasty state close to liquid; - The xyvinyl polymer and/or its salt are essential components, and the two components (1) and (b) are used to form a liquid or near-liquid paste at room temperature. Al is a fatty acid ester of a hydric alcohol,
If it is liquid at room temperature, it is very important that it be a paste close to liquid. This is because when preparing a water-in-oil emulsion using an emulsifier composition containing a high-melting fatty acid monoester that is solid at room temperature, the crystalline phase transitions over time at the oil/water interface rM in emulsion 1. This is because a solid interfacial film is formed, which lacks viscoelasticity and impairs the storage stability of the emulsion.

Components of the emulsifier used in the present invention (monoester of altia triglycerol and zhen fat men), the trihydric alcohol is preferably glycerin and/or trimethylolpropane, and the fatty acids are capric acid, lauric acid, Oleic acid and instearic acid at least 1 type selected from 8-carbon or Japanese fatty acids such as oleic acid, linoleic acid, ricinoleic acid, isooctanoic acid, impalmitin i#, and oyohiisostearic acid. is preferred.

Preferred components (-) include glyceryl monooleate, glyceryl monoinstearate, trimethylolpropane monooleate, and trimethylolpropane monoisostearate.

Ingredients used in the emulsion treatment of the present invention (bl t!
Examples of the base for forming a salt with the carboxyvinyl polymer and/or its salt include sodium, potassium, ammonia, alkanolamines, and basic amino acids. A typical carboxyvinyl polymer is one obtained by polymerizing acrylic acid, and is described, for example, in Cosmetic Raw Materials Standard Supplementary Commentary (published by Yakuji Nippo Co., Ltd.), pages 59 to 66. As for what is currently on the market.

Carboball (trade name) manufactured by Gutdrich Chemical Co., USA, and Ibis Wako manufactured by Wako Tsumugi Kogyo Co., Ltd. (b) component (t) 0.03 to 1.0 parts by weight are used.

The emulsifier composition of the present invention is superior because the carboxyvinyl polymer has a polymer structure having a large number of carboxyl groups, and is characterized by strong water absorption. In the water-in-oil emulsion bottle of the present invention, it plays an important role in stably dispersing water particles in the oil phase. This is clear from the fact that when a fatty acid monoester is mixed with an aqueous solution of divinyl polymer in a carboxylic acid, an extremely strong gel is formed, and the aqueous phase has the ability to maintain a seemingly solid state. Oily substances with different polarities can be used as the basic component in the water bottle. For example, aliphatic hydrocarbons such as mineral oil, petrolatum, nocturnal oil, squalane, isopropyl mi-state and inpropyl paldate, cetyl 2-ethylhexanoate and triglyceride 2-ethylhexanoate.
Synthetic ester oils such as J-Celite, OII-F oil, #joba oil, natural oils such as wheat germ oil and 2-ink oil, natural waxes such as Airou 1-wax, Karnara/< wax, hardened and mustard oil. Easy base emulsion solvents can be prepared using hydrogenated oils and the like. Although the main component of the aqueous component to be dispersed in the oily medium is water, water-soluble additives can be added that impart other functional properties, such as lowering the overall freezing temperature, and for this purpose. Examples include propylene glycol, butylene glycol,
Examples include water-soluble polyols such as salt, sorbitol, maltitol, and hexylene glycol, and water-soluble inorganic salts such as common salt and potassium salt.

Similarly, for pharmaceutical formulations, it must be possible to incorporate therapeutic agents into topical formulations without altering the emulsion properties of the overall composition.

- In addition, pharmaceutical emulsions must be effective over a relatively wide pHg range of about 3.5 to 9.0 without destroying the emulsification. In this regard, one of the features of the water-in-oil emulsion of the present invention is that it can contain large amounts of various water-soluble medicinal ingredients such as urea, lactic acid, and others in the aqueous phase.

When preparing the emulsion blind of the present invention, it is possible to emulsify sufficiently without using any other emulsifier other than the above-mentioned emulsifier, but this does not preclude the use of other emulsifiers as an auxiliary, such as Other so-called lipophilic emulsifiers with low HLB may also be added to the oil phase.

In the method of emulsion sealing t-l1i1 of the present invention, 3
A method of preparing an emulsifier composition tm by emulsifying a monoester of alcohol and a carboxyvinyl polymer, and adding a base oil component and an aqueous component to this to obtain an emulsion carbonate, and a method of adding a monoester to the oil component to obtain an aqueous component. Carboxyvinyl poly inside? No matter which method is selected, in which the two components are mixed and emulsified with a difference of 7jO to -1, the emulsification is completed completely and the desired emulsion can be obtained.

The emulsion of the present invention can be used as a base for cosmetics such as creams and medicinal preparations such as ointments. As shown in the examples below, the characteristics of this product are that we have developed a water-in-oil emulsion with a relatively high ratio of aqueous components to oily components, and this product is highly homogeneous to the skin.
When used, a product with a light feel and excellent moisturizing properties can be obtained.

The edema-in-oil emulsion of the present invention can be used with various other am preparations 1
For example, preservatives, antioxidants, bactericidal agents, fragrances, pigments, medicinal agents, etc. can be added.

The present invention will be described in detail with reference to Examples below.

The middle part of the example indicates the weight St.

Example 1 Preparation of Cuderm stored in a VWroll 1.0 part of glyceryl monooleate was stirred well, and divinyl polymer in Hecarpo was prepared as Carboball 934 (manufactured by Gutdrich Chemical Co., USA; trade name (hereinafter the same). 20 parts of IIG aqueous solution of )) was added in small amounts. Add an aqueous solution (thus, the product increases in hardness and a gel-like emulsifier composition is obtained. 4.0 parts of liquid paraffin is added to this composition.

2.0 parts of ceresin, 2.0 parts of silicone oil, and 2.0 parts of cetyl 2-ethylhexanoate were added, and the temperature was raised to 70C while stirring well. Meanwhile, 64.4 parts of water, 70
5 parts of sorbitol aqueous solution plus preservative (methylparaben)
The same applies hereinafter)) 0.1 part was added and heated to 70C.

The latter aqueous phase was added little by little to the former oil phase while stirring, and after the addition was completed, the mixture was stirred at 70C for 5 minutes, and then allowed to cool to room temperature while stirring to obtain a protective cream.

When the air resistance value was measured, it showed infinity, proving that water did not form a continuous phase, and it was recognized that it formed a W/ell structure. Divide this book into three parts: QC, 20C.

40CK was stored for 6 months, but there was no separation of oil and water.
The emulsion was kept stable.

Example 2 Preparation of W1011 trowel cream An emulsifier composition was obtained by using trimethylolpronoisostelate in place of glyceryl monooleate in Example 1, and a cream similar to that of Example 1 was prepared by the same procedure. I got it.

Example 3 Preparation of w7o* cleansing cream Glyceryl monoisostearate LOIS, sulfate ao part, fluidity (rough-in 20.0s, selenium LOIS)
11. White Vaseline! Mix the LO part and heat and dissolve?
Or. On the other hand, )゛0 sorbitol 6.01B,
14 water solution 1 [14.0 parts of Carbobo 3140 (U.S., Gutsud 1J Tsuchi Chemiru Co., Ltd. II: trade name (the same applies hereinafter)), 417 parts of water, and 0.2 parts of fat preservative in 72 cvc and uniformly
l! This was added to the oily component while stirring to emulsify it. ) Stir in OC for 5 minutes, then let it cool for 4SC.
When the temperature reached K, the flavoring agent was added and stirring was continued until the temperature reached vcsoc.

This product had a fine and glossy appearance. When the electrical resistance value was measured, it showed infinity of 1000 MΩ or more, and it was confirmed that a W10 type emulsion tube was formed. This thing f OC.

Emulsion stability was determined by repeating the freezing-thawing Sakai cycle three times, alternating every other week at -20C and -20C for 6 months at 2oC% and 40C, but the emulsion did not break in either case. In addition, regarding the feeling of use, it was found that there was no stickiness and the feel was rated at 9.

Example 4 Oil component glyceryl monooleate 1□0IB2-Ethylhexane storage ester! Loll diglycerine dioleade 10 parts liquid paraffin
° to, oIl white 9 seri/z, o s aqueous component glycerin! L011 Carbopol 94o 1 Vomit Solution 10.0 parts Preservative M
O, 1 part water
Using 60.9 parts, Skin Cree-5 was obtained using emulsification according to Example 3. From the electrical resistance value of this thing, W2
It was found to be type O, and when the emulsion stability was tested in the same manner as in Example 3, it was stable by all methods.

Example 5 Oil component Glyceryl monoinstearate 2.0 parts Liquid paraffin 10.0 parts Ethylhexanoic acid triglyceride 7.0 parts Ceresin
3.0 part White Waryu Rin
8. . Secret talk
2.0% aqueous component 7011 norpitot/' 10 parts Glycerin 10 parts 1'l Carbobol 934 aqueous solution (adjusted to pH 6.3 with NaOH) 1! L
oll preservative 0.21
Sodium 1-pyrrolidone-5-carboxylate 1.5s water
Emulsification was carried out according to Example 3 using 37.3 parts of both oil-based and aqueous components TL-75c. It was confirmed that it was a W10 type emulsion from the electrical resistance value, and as in Example 3 (an emulsion stability test was performed, it was found to be stable. It was not sticky during use).

Despite its light feel, it was noted to provide moisturizing properties to the skin.

Example 6 Preparation of W10 type urea ointment Oil component glyceryl monoinstearate 3.0 il semi-hardened soybean oil (melted, $37 tl') 18.0 II hydrogenated castor oil λos aqueous component 1.3-butylene glycol &0 parts 1 hour carb Ball 9'34. 'Aqueous solution 40.0ml preservative 0.2 parts water
11
．． After uniformly dissolving the 811 aqueous component at 80C,
After cooling at oct, 20.0 parts of the element was added and uniformly dissolved. Meanwhile, heat the oily component to 80C and homogenize it.
Dissolve the mixture and add the aqueous component to the mixture while stirring.

Stirring was performed while cooling until the temperature reached 30C. The electrical resistance value of the obtained product confirmed that it was a W10 type emulsion, and the same results as in Example 3 were obtained in the stability test.

Claims (1)

[Scope of Claims] 1. In a water-in-oil emulsion, as an emulsifier (a) a monoester of a trihydric alcohol and a fatty acid having 8 or more carbon atoms, which exhibits a liquid or near-liquid paste form at room temperature; Two components of divinyl polymer in carbo are essential components, and the usage ratio of heat and b is 1
A water-in-oil emulsion, characterized in that it is emulsified using 0.03 to 1.0 parts by weight of b to 1.0 parts by weight. 2. The emulsion according to claim 1, wherein in the monoester of 13-alcohol and fatty acid, the constituting trihydric alcohol is either glycerin or trimethylolpropane, or a mixture of both. 1. In monoesters of trihydric alcohols and fatty acids,
The emulgene according to claim 1, wherein the constituent fatty acid is either oleic acid or inostearic acid, or a mixture of both. 4. In the carboxypinyl carbon I) polymer, the divinyl polymer in the carboxylic acid contains the free acid, sodium salt, and divinyl polymer.
The emulgene according to claim 1, which is at least one of a lium salt, an ammonium salt, an ethanolamine salt, and a basic amino acid salt.