JPS6186940A - Oil in water type emulsion composition - Google Patents

Oil in water type emulsion composition

Info

Publication number
JPS6186940A
JPS6186940A JP59206513A JP20651384A JPS6186940A JP S6186940 A JPS6186940 A JP S6186940A JP 59206513 A JP59206513 A JP 59206513A JP 20651384 A JP20651384 A JP 20651384A JP S6186940 A JPS6186940 A JP S6186940A
Authority
JP
Japan
Prior art keywords
oil
composition
emulsion composition
alkyl phosphate
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP59206513A
Other languages
Japanese (ja)
Inventor
Ichiro Sukai
一郎 須貝
Yoshinori Takema
武馬　吉則
Masatoshi Arisawa
有沢　正俊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Priority to JP59206513A priority Critical patent/JPS6186940A/en
Publication of JPS6186940A publication Critical patent/JPS6186940A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/556—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Colloid Chemistry (AREA)

Abstract

PURPOSE:To reduce the irritation to the skin and to improve stability, by adding an oil component to a mixture of polyhydric alcohol having two or more hydroxyl groups in the molecule thereof, alkyl phosphate and a base before further adding water thereto. CONSTITUTION:5-98wt% (on the basis of a total composition, same hereinbelow) of polyhydric alcohol having two or more of hydroxyl groups in the molecule thereof, 0.1-5wt% of alkyl phosphate and 0.01-4wt% of a base are mixed under heating to prepare a gel like composition. 1-90wt% of an oil component is added to this composition to prepare an oil in water type emulsion composition. As alkyl phosphate, a compound represented by formula I or II (wherein R1 and R4 are an 8-22C straight chain alkyl group or an 8-22C straight chain alkenyl group, R3 and R4 are an ethylene group or a propyl group and m and n are 0-30) is designated.

Description

【発明の詳細な説明】 〔産業上の利用分野〕 本発明は水中油型乳化組成物、更に詳細には、乳化剤と
してアルキルリン酸エステル塩を利用した、安全性が高
く、使用感が良好で、刺激性が少ない、化粧料又は医薬
品基剤として好適な水中油型乳化組成物に関する。[Detailed Description of the Invention] [Field of Industrial Application] The present invention provides an oil-in-water emulsion composition, more specifically, an oil-in-water emulsion composition, which uses an alkyl phosphate ester salt as an emulsifier, is highly safe and has a good feeling of use. , relates to an oil-in-water emulsion composition that is less irritating and suitable as a cosmetic or pharmaceutical base.

〔従来の技術〕[Conventional technology]

従来、化粧料等に用いられる水中油型乳化組成物は、一
般に油基剤を通常の界面活性剤で乳化する方法によって
製造されていた。しかし、従来使用されていた界面活性
剤は大量に使用すると皮膚刺激を与えるという問題点が
あった、そのため皮膚刺激のない安全な乳化剤について
の研究がなされ、近年、シヨ塘脂肪酸エステルと非イオ
ン界面活性剤を用いて多価アル占−ル中油型乳化組成物
を得る方法が報告された（％開昭５６−５５３０６号）
。Conventionally, oil-in-water emulsion compositions used in cosmetics and the like have generally been produced by emulsifying an oil base with a common surfactant. However, conventionally used surfactants have had the problem of irritating the skin when used in large quantities.Therefore, research has been conducted into safe emulsifiers that do not irritate the skin, and in recent years, surfactants such as Siyotang fatty acid esters and nonionic interfaces have been developed. A method for obtaining an oil-in-polyhydric alkaline emulsion composition using an activator was reported (% 1983-55306).
.

〔発明が解決しようとする問題点〕[Problem that the invention seeks to solve]

しかしながら、この方法によって得られた多価アルコー
ル中油型乳化組成物に水を加えてなる水中油型乳化組成
物は乳化安定性はよいが、使用時のべとつき、保存後の
変色、脂肪酸臭の発生等に問題がある。However, although the oil-in-water emulsion composition obtained by adding water to the oil-in-polyhydric alcohol emulsion composition obtained by this method has good emulsion stability, it is sticky during use, discolors after storage, and produces fatty acid odor. etc. There is a problem.

〔問題点を解決するための手段〕[Means for solving problems]

本発明者は、皮膚に対する刺激性が低く、かつ、安定性
、使用感ともに優れた乳化組成物を得るべく鋭意研究を
重ねた結果、多価アルコールにアルキルリン酸エステル
及び塩基を加えて加熱混合して得られるゲル状組成物に
油分を加え、更に水を加えて混合することにより上記目
的に叶った水中油型乳化組成物が得られることを見出し
、本発明を完成したつ すなわち本発明は、分子内に２個以上の水酸基を有する
多価アルコール、アルキルリン酸エステル及び塩基を加
熱混合して得られるゲル状組成物に油分を加え、更に水
を加えてなる水中油型乳化組成物を提供するものである
。As a result of extensive research in order to obtain an emulsified composition that is less irritating to the skin and has excellent stability and usability, the present inventor added an alkyl phosphate ester and a base to a polyhydric alcohol and mixed it with heat. It has been discovered that an oil-in-water emulsion composition that satisfies the above objectives can be obtained by adding an oil component to the gel-like composition obtained by adding water, and then mixing the resulting gel composition, and has completed the present invention. An oil-in-water emulsion composition is obtained by adding an oil component to a gel-like composition obtained by heating and mixing a polyhydric alcohol having two or more hydroxyl groups in the molecule, an alkyl phosphate ester, and a base, and further adding water. This is what we provide.

本発明で使用されるアルキルリン酸エステルは、置換度
２以下の化合物であり、例えば次式（Ｉ）又は／及び（
旧 Ｒ ■ Ｒ１−Ｇ−ＯＲ２−）ＨＯ−π−ＯＨ ０−４４３−０輻Ｒ４ Ｒｌ−４−ＯＲ２＋ｎ　ＯＰ　　ＯＨ（ＩＩ　）（式中
、Ｒ１及びＲ４は炭素数８〜２２の直鎖アルキル基又は
直鎖アルケニル基を示し、Ｒ３及びＲ４はエチレン基又
はプロピレン基を示し、ｍ及びｎは０〜３０の数を示す
） で表わされるものが好適なものとして挙げられる。The alkyl phosphate ester used in the present invention is a compound having a degree of substitution of 2 or less, for example, the following formula (I) or/and (
Former R ■ R1-G-OR2-) HO-π-OH 0-443-0 R4 Rl-4-OR2+n OP OH (II) (wherein, R1 and R4 are linear alkyl groups having 8 to 22 carbon atoms or a linear alkenyl group, R3 and R4 represent an ethylene group or a propylene group, and m and n represent numbers from 0 to 30).

アルキルリン酸エステルは、本発明の水中油型乳化組成
物の全組成に対し０．１〜１５．０重量％（以下、単に
チで示す）、好ましくは１．０〜１０，０％配合される
。０．１％よυ少ない場合には、当該ゲル状組成物を形
成せず、１５．０％を超える場合にはゲルが固化してし
まい好ましくない。なお、アルキルリン酸ニステルハ、
モノエステル／ジエステル比（重量比）が１以上となる
ように使用するのが好ましい。The alkyl phosphate ester is blended in an amount of 0.1 to 15.0% by weight (hereinafter simply indicated as H), preferably 1.0 to 10.0%, based on the total composition of the oil-in-water emulsion composition of the present invention. Ru. If it is less than 0.1%, the gel-like composition will not be formed, and if it exceeds 15.0%, the gel will solidify, which is not preferable. In addition, alkyl phosphate Nistelha,
It is preferable to use them so that the monoester/diester ratio (weight ratio) is 1 or more.

本発明で使用される塩基としては、例えば水酸化ナトリ
ウム、水酸化カリウム、水酸化リチウム等のアルキル金
属水酸化物；トリエタノールアミン、ジェタノールアミ
ン、モノエタノールアミン等の炭素数２又は３のヒドロ
キシアルキル基を有するアルカノールアミン；ＤＬ−ア
ルギニン、Ｄ−アルギニン、Ｌ−アルギニン、ＤＬ−リ
ジン、Ｄ−リジン、Ｌ−リジン、ＤＬ−オルニチン、Ｄ
−オルニテン、Ｌ−オルニチン等の塩基性アミノ酸が挙
げられ、就中特に塩基性アミノ酸が好ましい。これらの
塩基は、単独で又は２種以上を組み合せて、本発明の水
中油型組成物の全組成に対し０．０１〜１４．０％、好
ましくは０．５〜１０．０％配合される。Examples of the base used in the present invention include alkyl metal hydroxides such as sodium hydroxide, potassium hydroxide, and lithium hydroxide; Alkanolamines having an alkyl group; DL-arginine, D-arginine, L-arginine, DL-lysine, D-lysine, L-lysine, DL-ornithine, D
-ornithine, L-ornithine, and other basic amino acids, among which basic amino acids are particularly preferred. These bases may be used alone or in combination of two or more in an amount of 0.01 to 14.0%, preferably 0.5 to 10.0%, based on the total composition of the oil-in-water composition of the present invention. .

また、本発明で使用される分子内に２個以上の水酸基を
有する多価アルコールとしては、例えばプロピレングリ
コール、１，３−ブタンジオール、ジプロピレングリコ
ール、グリセリン、ジグリセリン、ポリグリセリン、ト
リメチロールプロパン、エリスリトール、ペンタエリス
リトール、ンルビタン、グルコース、ンルビトール、マ
ルチトール、サッカロース、トレハロース、ポリオキシ
エチレンメチルグルコシド、ポリオキシプロピレンメチ
ルグルコシドが挙げられ、就中特に１，３−ブタンジオ
ール、ジプロピレングリコール、グリセリン、ンルビト
ール、マルチトールが好ましい。これらは単独で又は２
種以上を組み合せて使用される。分子内に２個以上の水
酸基を有する多価アルコールの使用量は、乳化組成物の
使用感、粘稠性などにより変化するが、本発明の水中油
型乳化組成物の全組成に対し５〜９８％、好ましくは１
５〜８０チ配合される。In addition, examples of the polyhydric alcohol having two or more hydroxyl groups in the molecule used in the present invention include propylene glycol, 1,3-butanediol, dipropylene glycol, glycerin, diglycerin, polyglycerin, and trimethylolpropane. , erythritol, pentaerythritol, nrubitan, glucose, nrbitol, maltitol, saccharose, trehalose, polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, especially 1,3-butanediol, dipropylene glycol, glycerin, Preferred are nlubitol and maltitol. These can be used alone or in combination
Used in combination of more than one species. The amount of polyhydric alcohol having two or more hydroxyl groups in the molecule varies depending on the feel of the emulsion composition, viscosity, etc. 98%, preferably 1
5 to 80 pieces are mixed.

本発明で使用される油分は、化粧料、医薬品等に通常使
用される常温で固体から液体のものまでいずれをも使用
でき、例えば炭化水素類、高級アルコール高級脂肪酸エ
ステル類、グリコール高級脂肪酸エステル類、高級アル
コール類、高級脂肪酸類、動植物油脂、コレステロール
脂肪酸エステル類、香料等が挙げられ、好ましいものと
しては流動パラフィン、スクワラン、インステアリルコ
レステリルエステル、２−エチルヘキサン酸トリグリセ
リド、ミリスチン酸インプロピル、ワセリン等が挙げら
れる。これらは単独で又は２種以上を組み合せて使用さ
れる。油分は、乳化組成物の使用目的により、本発明の
水中油型乳化組成物の全組成に対し１．０〜９０．０％
、好ましくは１０〜８０％配合される。The oil used in the present invention can be anything from solid to liquid at room temperature, which is commonly used in cosmetics, pharmaceuticals, etc., such as hydrocarbons, higher alcohol higher fatty acid esters, glycol higher fatty acid esters, etc. , higher alcohols, higher fatty acids, animal and vegetable oils and fats, cholesterol fatty acid esters, fragrances, etc., and preferred ones include liquid paraffin, squalane, instearyl cholesteryl ester, 2-ethylhexanoic acid triglyceride, impropyl myristate, and petrolatum. etc. These may be used alone or in combination of two or more. The oil content ranges from 1.0 to 90.0% based on the total composition of the oil-in-water emulsion composition of the present invention, depending on the purpose of use of the emulsion composition.
, preferably 10 to 80%.

また、水分量は乳化組成物の使用目的、必要とする物性
に応じて適宜選択しうるが、１〜９０％、特に５〜７０
％の範囲が好ましい。In addition, the water content can be appropriately selected depending on the purpose of use of the emulsified composition and the required physical properties, but is 1 to 90%, particularly 5 to 70%.
A range of % is preferred.

本発明の水中油型乳化組成物を製造するには、まず分子
内に２個以上の水酸基を有する多価アルコール、アルキ
ルリン酸エステル及び塩基を加熱混合してゲル状組成物
を得る。この場合、アルキルリン酸エステル及び塩基は
、多価アルコールに個々に配合しても、予め別の系で部
分的に又は完全に中和したアルキルリン酸エステル中和
物の形で配合することもできる。そして、アルキルリン
酸エステルは多価アルコールのｌ／１００〜２重量倍、
好ましくは１／２０〜２／３重景倍、塩基は水中油型乳
化組成物のｐＨが２〜１０、好ましくは４〜７になるよ
うに配合される。次いで、上記ゲル状組成物に油分を加
え十分攪拌混合し、更に水を加えて攪拌混合する。油分
は、ゲル状組成物に対し、１／１００〜１０重量倍、特
に１１５０〜５重量倍配合するのが好ましい。！た。水
分はゲル状組成物に対し１／１００〜１０重量倍、特に
１１５０〜５重量倍とするのが好ましい。To produce the oil-in-water emulsion composition of the present invention, first, a polyhydric alcohol having two or more hydroxyl groups in the molecule, an alkyl phosphate ester, and a base are heated and mixed to obtain a gel-like composition. In this case, the alkyl phosphate ester and base may be blended individually with the polyhydric alcohol, or may be blended in the form of a neutralized alkyl phosphate ester that has been partially or completely neutralized in a separate system. can. And the alkyl phosphate ester is 1/100 to 2 times the weight of the polyhydric alcohol,
Preferably, the base is blended so that the pH of the oil-in-water emulsion composition is 2-10, preferably 4-7. Next, an oil component is added to the gel composition and thoroughly mixed with stirring, and water is further added and mixed with stirring. The oil content is preferably blended in an amount of 1/100 to 10 times, particularly 1150 to 5 times, the weight of the gel composition. ! Ta. The amount of water is preferably 1/100 to 10 times, particularly 1150 to 5 times, the weight of the gel composition.

本発明の水中油型乳化組成物には、上記必須成分のほか
に、化粧料、医薬品等に通常使用される香料、薬効剤、
殺菌剤、色素等を必要に応じて配合することができる。In addition to the above-mentioned essential ingredients, the oil-in-water emulsion composition of the present invention contains fragrances and medicinal agents commonly used in cosmetics, pharmaceuticals, etc.
Bactericides, pigments, etc. can be added as necessary.

〔作用〕[Effect]

分子内に２個以上の水酸基を有する多価アルコールにア
ルキルリン酸エステル及び塩基を加え加熱混合すると、
特にアルキルリン酸エステル及び塩基の優れた乳化作用
によシ、ゲル状の均一で安定な強固な構造を有する液晶
相が形成される。かかる均一相に油分を加えると、油分
は多価アルコール相に均一に内包される。更に、これに
水を加えて混合することにより、他の乳化剤あるいは強
力なエネルギーを加えるといった物理的手段を要せず、
微粒子の均一な水中油型乳化組成物が形成される。When an alkyl phosphate ester and a base are added to a polyhydric alcohol having two or more hydroxyl groups in the molecule and mixed with heating,
In particular, due to the excellent emulsifying effect of the alkyl phosphate ester and the base, a liquid crystal phase having a gel-like uniform, stable, and strong structure is formed. When oil is added to such a homogeneous phase, the oil is uniformly encapsulated in the polyhydric alcohol phase. Furthermore, by adding water to this and mixing it, there is no need for physical means such as adding other emulsifiers or strong energy.
A finely divided, uniform oil-in-water emulsion composition is formed.

〔発明の効果〕〔Effect of the invention〕

本発明の水中油型乳化組成物は均一で、皮膚への刺激が
低く、保存安定性、匂いの安定性に優れ、しかも使用感
が良好であるので、乳化化粧料、医薬品、医薬部外品基
剤等に好適に使用できる。The oil-in-water emulsion composition of the present invention is uniform, has low irritation to the skin, has excellent storage stability and odor stability, and has a good feeling of use, so it can be used in emulsified cosmetics, pharmaceuticals, and quasi-drugs. It can be suitably used as a base and the like.

〔実施例〕〔Example〕

次に実施例を挙げて本発明を説明するが、本発明はこれ
ら実施例に制限されるものではない。Next, the present invention will be explained with reference to Examples, but the present invention is not limited to these Examples.

実施例１ 下記第１表に示す乳化組成物を次の方法により調製し、
その外観、使用感、硬さ及び安定性を評価した。結果を
第１表に示す。Example 1 An emulsion composition shown in Table 1 below was prepared by the following method,
Its appearance, feel, hardness and stability were evaluated. The results are shown in Table 1.

（製造法） 表中、■〜■を７０℃に加熱混合溶解し、第１次ゲル状
組成物を調製する。これに予め７０℃に加熱混合した■
を徐々に加えラボミクサーで攪拌混合する。次いで、更
に■を徐々に加えラボミクサーで攪拌混合し乳化する。(Manufacturing method) In the table, ① to ② are heated, mixed and dissolved at 70°C to prepare a first gel composition. This was heated and mixed at 70℃ in advance.■
Gradually add and mix using a lab mixer. Next, gradually add (1) and stir and mix using a lab mixer to emulsify.

これを３０℃まで攪拌冷却して本発明乳化組成物を得る
。This is stirred and cooled to 30° C. to obtain an emulsion composition of the present invention.

ＹすＪ１ｚ超′］ 第１表 寮内相比：■／（■＋■＋■十〇＋■）実施例２ 下記第２表に示す乳化組成物を次の方法により調製し、
その外観、乳化粒子の粒径、安定性、硬さ及び使用感を
評価した。結果を第２表に示す。YsuJ1z>] Table 1 Dormitory phase ratio: ■/(■+■+■10+■) Example 2 The emulsion composition shown in Table 2 below was prepared by the following method,
The appearance, particle size of emulsified particles, stability, hardness, and feeling of use were evaluated. The results are shown in Table 2.

（製造法） 実施例１と同様に、ンルビトール、ラウリルリン酸及び
水酸化カリウムを加熱混合し、その中にスクワラン、イ
ンステアリルコレステリルエステルを徐々に混合し、更
に水を加えて配合物を調製した。(Manufacturing method) In the same manner as in Example 1, nrubitol, lauryl phosphate and potassium hydroxide were heated and mixed, squalane and instearyl cholesteryl ester were gradually mixed therein, and water was further added to prepare a formulation. .

以、１で余白 比較品Ａは、ンルビトール、油性成分のゲル状物は全く
できず、水添加により速かに分離した。Hereinafter, in No. 1, margin comparison product A did not form any gelatinous substance of nlubitol and oily components, and was quickly separated by the addition of water.

比較品Ｂは、加熱乳化時は白色クリーム状であるが、冷
却により固化し、やがて分離した。これに対し、本発明
品はいずれも良好な乳化物であった。Comparative product B was white and creamy when heated and emulsified, but solidified upon cooling and eventually separated. In contrast, all of the products of the present invention were good emulsions.

実施例３ 下記第３表に示す乳化組成物を実施例１と同様にして調
製し、その外観、硬さ、分離安定性、匂いの安定性及び
使用感を評価した。結果を第３表に示す。Example 3 Emulsified compositions shown in Table 3 below were prepared in the same manner as in Example 1, and their appearance, hardness, separation stability, odor stability, and feeling of use were evaluated. The results are shown in Table 3.

２１、ｌ′：ｚ：’＝口 比較品Ｃは乳化剤としてショ糖脂肪酸エステルを使った
ものであり、組成物の外観、硬さ、分離安定性は本発明
品と同等であるが、匂いの安定性が悪いこと、べとつい
て使用感が悪いこと等の欠点を有していた。これに対し
、本発明品は、匂いの安定性、使用感の点でも良好なも
のであった。21, l':z:'=mouth Comparative product C uses sucrose fatty acid ester as an emulsifier, and the appearance, hardness, and separation stability of the composition are the same as the product of the present invention, but the odor is It had drawbacks such as poor stability and sticky feeling when used. On the other hand, the product of the present invention was good in terms of odor stability and feeling of use.

実施例４ 化粧料（栄養クリーム） （糸目、成　） グリセリン　　　　　　　　　　　２５（％）プロピレ
ングリコール　　　　　　　　５ラウリルリン酸　　　
　　　　　　　　３ジラウリルリン酸　　　　　　　　
　　ＩＬ−アルギニン　　　　　　　　　　　１．８２
−エチルヘキサン酸トリグリセリド　１５スクワラン　
　　　　　　　　　　　１５インステアリルコレステリ
ルエステル　３０酢酸−ｄｔ−α−トコフェロール　　
　０．２ジブチルヒドロキシトルエン　　　　　０．０
１メテルノ々ラベン　　　　　　　　　　　０．１清製
氷　　　　　　　　　　　　　　　　　　バランスリッ
チな感触で使用感がよく、乳化安定性、匂いの安定性も
良好であった。Example 4 Cosmetics (Nutritional Cream) (Itome, Sei) Glycerin 25 (%) Propylene Glycol 5 Lauryl Phosphoric Acid
3 dilauryl phosphate
IL-Arginine 1.82
-Ethylhexanoic acid triglyceride 15 squalane
15 Instearyl cholesteryl ester 30 Acetate-dt-α-tocopherol
0.2 Dibutylhydroxytoluene 0.0
1 Meternolaben 0.1 Clear ice It had a well-balanced and rich feel and was pleasant to use, and had good emulsion stability and odor stability.

実施例５ 化粧料（乳液） （組成） １．３−ブチレングリコール　　　　１０（％）ジプロ
ピレングリコール　　　　　　　５ポリオキシエテレン
セテルリン酸　　　５（２０Ｅ、　Ｏ，） 水酸化カリウム　　　　　　　　　　　０．２５流動パ
ラフイン　　　　　　　　　　　５ミリスチン酸インプ
ロピル　　　　　　１０ワセリン　　　　　　　　　　
　　　　４メテルノｆラベン　　　　　　　　　　　０
．２精製水　　　　　　　　　　　　　　　バランスべ
とつかず、さっばりして使用感がよく、乳化安定性、匂
いの安定性も良好であった。Example 5 Cosmetic (emulsion) (Composition) 1.3-Butylene glycol 10 (%) Dipropylene glycol 5 Polyoxyetelenceteric acid 5 (20E, O,) Potassium hydroxide 0.25 Liquid paraffin 5 In myristate Propyl 10 Vaseline
4 Meterno f Laben 0
．． 2 Purified water Balance: It was not sticky, had a light feel and had a good feel when used, and had good emulsion stability and odor stability.

実施例６ 医薬品基剤 Ｃ組成） グリセリン　　　　　　　　　　４０（％）セチルリン
酸　　　　　　　　　　　　４水酸イはトリウム　　　
　　　　　　０．５ワセリン　　　　　　　　　　　　
５０Ｂ）ＩＴ ０．０１ ブナルパラベン　　　　　　　　　　０．ｏ５精製水　
　　　　　　　　　　　　　　　　　バランスこの基剤
をベースにすることにょシ、種々の油溶性薬剤を練り込
むことができる。Example 6 Pharmaceutical base C composition) Glycerin 40 (%) cetyl phosphate Tetrahydroxide is thorium
0.5 Vaseline
50B) IT 0.01 Bunalparaben 0. o5 purified water
Balance: Based on this base, various oil-soluble drugs can be incorporated.

以上that's all

Claims (1)

【特許請求の範囲】 １、分子内に２個以上の水酸基を有する多価アルコール
、アルキルリン酸エステル及び塩基を加熱混合して得ら
れるゲル状組成物に油分を加え更に水を加えてなる水中
油型乳化組成物。 ２、アルキルリン酸エステルが次式（ I ）又は／及び
（II） ▲数式、化学式、表等があります▼（ I ） ▲数式、化学式、表等があります▼（II） （式中、Ｒ＿１及びＲ＿４は炭素数８〜２２の直鎖アル
キル基又は直鎖アルケニル基を示し、Ｒ＿３及びＲ＿４
はエチレン基又はプロピレン基を示し、ｍ及びｎは０〜
３０の数を示す） で表わされるものである特許請求の範囲第１項記載の水
中油型乳化組成物。 ３、全組成に対して、多価アルコールが５〜９８重量％
、アルキルリン酸エステルが０．１〜１５重量％、塩基
が０．０１〜１４重量％、油分が１〜９０重量％及び水
が１〜９０重量％である特許請求の範囲第１項又は第２
項記載の水中油型乳化組成物。[Claims] 1. A gel composition obtained by heating and mixing a polyhydric alcohol having two or more hydroxyl groups in the molecule, an alkyl phosphate ester, and a base, an oil component, and further water. Oil type emulsion composition. 2. The alkyl phosphate ester has the following formula (I) or/and (II) ▲There are mathematical formulas, chemical formulas, tables, etc.▼(I) ▲There are mathematical formulas, chemical formulas, tables, etc.▼(II) (In the formula, R_1 and R_4 represents a straight-chain alkyl group or a straight-chain alkenyl group having 8 to 22 carbon atoms, and R_3 and R_4
represents an ethylene group or a propylene group, m and n are 0 to
30) The oil-in-water emulsion composition according to claim 1, which is represented by the following formula. 3. Polyhydric alcohol is 5-98% by weight based on the total composition
, the alkyl phosphate ester is 0.1 to 15% by weight, the base is 0.01 to 14% by weight, the oil content is 1 to 90% by weight, and the water is 1 to 90% by weight. 2
The oil-in-water emulsion composition described in 2.
JP59206513A 1984-10-02 1984-10-02 Oil in water type emulsion composition Pending JPS6186940A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP59206513A JPS6186940A (en) 1984-10-02 1984-10-02 Oil in water type emulsion composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59206513A JPS6186940A (en) 1984-10-02 1984-10-02 Oil in water type emulsion composition

Publications (1)

Publication Number Publication Date
JPS6186940A true JPS6186940A (en) 1986-05-02

Family

ID=16524605

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59206513A Pending JPS6186940A (en) 1984-10-02 1984-10-02 Oil in water type emulsion composition

Country Status (1)

Country Link
JP (1) JPS6186940A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01153607A (en) * 1987-12-11 1989-06-15 Kao Corp Composition for external application
JPH02277542A (en) * 1989-04-19 1990-11-14 Mikasa Kagaku Kogyo Kk Aqueous suspended composition
JP2006342122A (en) * 2005-06-10 2006-12-21 Kuraray Co Ltd Topical skin preparation
JP2008270846A (en) * 2003-10-03 2008-11-06 Fuji Electric Device Technology Co Ltd Manufacturing method of semiconductor device
JP2013144660A (en) * 2011-12-16 2013-07-25 Croda Japan Kk W/o/w type emulsion composition
US10071030B2 (en) 2010-02-05 2018-09-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
US10188670B2 (en) 2011-03-15 2019-01-29 Phosphagenics Limited Composition
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
US11753435B2 (en) 2016-12-21 2023-09-12 Avecho Biotechnology Limited Process

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS577235A (en) * 1980-06-17 1982-01-14 Nippon Saafuakutanto Kogyo Kk Preparation of emulsion
JPS596938A (en) * 1982-07-06 1984-01-14 Shiseido Co Ltd emulsifying composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS577235A (en) * 1980-06-17 1982-01-14 Nippon Saafuakutanto Kogyo Kk Preparation of emulsion
JPS596938A (en) * 1982-07-06 1984-01-14 Shiseido Co Ltd emulsifying composition

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01153607A (en) * 1987-12-11 1989-06-15 Kao Corp Composition for external application
JPH02277542A (en) * 1989-04-19 1990-11-14 Mikasa Kagaku Kogyo Kk Aqueous suspended composition
JP2008270846A (en) * 2003-10-03 2008-11-06 Fuji Electric Device Technology Co Ltd Manufacturing method of semiconductor device
JP2006342122A (en) * 2005-06-10 2006-12-21 Kuraray Co Ltd Topical skin preparation
US10071030B2 (en) 2010-02-05 2018-09-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
US10188670B2 (en) 2011-03-15 2019-01-29 Phosphagenics Limited Composition
JP2013144660A (en) * 2011-12-16 2013-07-25 Croda Japan Kk W/o/w type emulsion composition
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
US11753435B2 (en) 2016-12-21 2023-09-12 Avecho Biotechnology Limited Process

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