JPS59101459A - プロスタグランジン誘導体、その製法及び該誘導体を含有する製薬学的組成物 - Google Patents

プロスタグランジン誘導体、その製法及び該誘導体を含有する製薬学的組成物

Info

Publication number: JPS59101459A
Authority: JP; Japan
Prior art keywords: ene; fluoro; oxo; ynoic acid; dihydroxy
Prior art date: 1982-11-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP58207657A

Other languages

English (en)

Japanese (ja)

Inventor

フランコ・フアウスチニ

アキレ・パンツエリ

ワルタ−・モレツチ

カルメロ・ジヤンドルフイ

ロベルト・チエセラニ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Italia SRL

Original Assignee

Carlo Erba SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-09

Filing date

1983-11-07

Publication date

1984-06-12

1983-11-07 Application filed by Carlo Erba SpA filed Critical Carlo Erba SpA

1984-06-12 Publication of JPS59101459A publication Critical patent/JPS59101459A/ja

Status Pending legal-status Critical Current

Links

150000003180 prostaglandins Chemical class 0.000 title claims description 8
238000004519 manufacturing process Methods 0.000 title claims description 7
239000008194 pharmaceutical composition Substances 0.000 title description 2
239000002253 acid Substances 0.000 claims description 380
150000001408 amides Chemical class 0.000 claims description 164
150000001875 compounds Chemical class 0.000 claims description 100
-1 pyrrolyl- Chemical group 0.000 claims description 90
ZKWFSTHEYLJLEL-UHFFFAOYSA-N morpholine-4-carboxamide Chemical compound NC(=O)N1CCOCC1 ZKWFSTHEYLJLEL-UHFFFAOYSA-N 0.000 claims description 86
QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 claims description 61
239000001257 hydrogen Substances 0.000 claims description 51
229910052739 hydrogen Inorganic materials 0.000 claims description 51
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 39
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 34
150000003839 salts Chemical class 0.000 claims description 31
125000004043 oxo group Chemical group O=* 0.000 claims description 27
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 26
239000000203 mixture Substances 0.000 claims description 25
150000002431 hydrogen Chemical class 0.000 claims description 24
238000006243 chemical reaction Methods 0.000 claims description 22
125000006239 protecting group Chemical group 0.000 claims description 22
229910052757 nitrogen Inorganic materials 0.000 claims description 21
125000004430 oxygen atom Chemical group O* 0.000 claims description 15
125000000623 heterocyclic group Chemical group 0.000 claims description 14
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125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
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KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)

JP58207657A 1982-11-09 1983-11-07 プロスタグランジン誘導体、その製法及び該誘導体を含有する製薬学的組成物 Pending JPS59101459A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8231938		1982-11-09
GB08231938A GB2130575B (en)	1982-11-09	1982-11-09	Amide derivatives of 13, 14-didehydro-cycloalkyl-prostaglandins

Publications (1)

Publication Number	Publication Date
JPS59101459A true JPS59101459A (ja)	1984-06-12

Family

ID=10534131

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP58207657A Pending JPS59101459A (ja)	1982-11-09	1983-11-07	プロスタグランジン誘導体、その製法及び該誘導体を含有する製薬学的組成物

Country Status (4)

Country	Link
JP (1)	JPS59101459A (fr)
BE (1)	BE898169A (fr)
DE (1)	DE3338327A1 (fr)
GB (1)	GB2130575B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1088966B (it) *	1977-11-15	1985-06-10	Erba Carlo Spa	13,14-dideidro-prostaglandine
US4543353A (en) *	1981-11-27	1985-09-24	Farmitalia Carlo Erba S.P.A.	Ester and amide derivatives of 13,14-didehydro prostaglandins

1982
- 1982-11-09 GB GB08231938A patent/GB2130575B/en not_active Expired
1983
- 1983-10-21 DE DE19833338327 patent/DE3338327A1/de not_active Withdrawn
- 1983-11-07 BE BE0/211834A patent/BE898169A/fr not_active IP Right Cessation
- 1983-11-07 JP JP58207657A patent/JPS59101459A/ja active Pending

Also Published As

Publication number	Publication date
GB2130575A (en)	1984-06-06
DE3338327A1 (de)	1984-05-10
BE898169A (fr)	1984-05-07
GB2130575B (en)	1985-12-11

Publication	Publication Date	Title
EP0055208B1 (fr)	1985-03-13	Carbacyclines, procédé pour les préparer et leur utilisation comme médicaments
EP0059158B1 (fr)	1988-08-03	Azaprostacyclines, leur préparation et applications pharmaceutiques
CA1264320A (fr)	1990-01-09	Analogues des prostaglandines, procede de preparation et composes pharmaceutiques les contenant
DE2318785A1 (de)	1973-10-25	Prostansaeurederivate
GB2075976A (en)	1981-11-25	3-hydroxy and 3-oxo-prostaglandin analogues
EP0119949A1 (fr)	1984-09-26	Carbacyclines, leur procédé de préparation, et leur utilisation comme médicaments
EP0099538B1 (fr)	1991-09-11	Carbacyclines, procédé pour leur préparation et leur utilisation comme médicaments
EP0069692B1 (fr)	1988-03-02	Carbacyclines, leur préparation et application pharmaceutique
DE2510818C2 (de)	1983-11-17	Neue Prostaglandin-Analoge sowie ein Verfahren zu deren Herstellung, sowie Arzneimittel die diese enthalten
DE3430626A1 (de)	1985-04-04	16-fluor-16,17-didehydroprostanoide, verfahren zu deren herstellung und pharmazeutische praeparate
EP0105288B1 (fr)	1985-12-11	Carbacycline, preparation et utilisation
JPS59101459A (ja)	1984-06-12	プロスタグランジン誘導体、その製法及び該誘導体を含有する製薬学的組成物
DE2850885A1 (de)	1979-05-31	Bicyclische prostaglandine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische und veterinaermedizinische mittel
DE2847049C2 (de)	1987-04-16	13,14-Didehydro-prostaglandine, Verfahren zu ihrer Herstellung und sie enthaltendes pharmazeutisches oder veterinärmedizinisches Mittel
DE2534989A1 (de)	1976-02-26	Prostansaeurederivate
DE2739277A1 (de)	1978-03-16	11-deoxy-11-oxaprostaglandinverbindungen
EP0153274B1 (fr)	1990-05-16	Carbacyclines, procédé pour leur préparation et leur utilisation comme médicaments
US6071898A (en)	2000-06-06	Asiatic acid derivatives having modified A-ring
EP0051597B1 (fr)	1984-07-04	Nouveaux derives de prostacycline et leur preparation
EP0098794B1 (fr)	1988-04-27	Carbacyclines, procédé pour leur préparation et leur utilisation comme médicaments
DE2832372A1 (de)	1979-02-08	Prostaglandin-derivate, verfahren zu deren herstellung und endprodukte des herstellungsverfahrens
DE2716075A1 (de)	1978-02-23	Neue zwischenprodukte und verfahren zur herstellung von thromboxan-analoga
EP0113311B1 (fr)	1992-01-02	5-Fluorocarbacyclines, procédé pour leur préparation et leur utilisation comme médicaments
CH638195A5 (de)	1983-09-15	Prostacyclinanaloge.
DE3209702A1 (de)	1983-09-22	Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel