JPS591404A - Emulsifiable composition - Google Patents

Abstract

PURPOSE:To provide an emulsifiable composition giving an emulsion having high safety to the human body, fine particle size, and excellent stability, by dissolving a protein together with a phospholipid or its salt in a polyhydric alcohol, and adding an oil to the solution. CONSTITUTION:The objective emulsifiable composition contains (A) an emulsifier consisting of (i) phospholipids or their salts (e.g. phosphatidic acid, lecithin, etc.) which are known as naturally existing high-safety amphoteric substances and (ii) proteins or their salts (e.g. soybean protein, collagen, etc.) which are known as natural water-soluble polymers, (B) water-soluble polyhydric alcohols having >=2 hydroxyl groups in the molecule (e.g. ethylene glycol, glycerol, etc.) and (C) an oil component (e.g. beef tallow, vaseline, etc.). The emulsifiable composition can be converted to an O/W-type emulsified composition by adding water thereto.

Description

Detailed Description of the Invention The present invention uses phospholipids or their salts, which are known as naturally occurring and highly safe amphiphilic substances, and proteins or their salts, which are known as natural water-soluble polymer substances, as emulsifiers. and an emulsified composition obtained by blending this with a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule (hereinafter simply referred to as polyhydric alcohol) and an oil component, and this emulsified composition further contains The present invention relates to an oil-in-water emulsion composition obtained by adding water.

(Left below) In recent years, much research has been conducted on emulsification, and a large number of emulsifiers have been developed.1 Also, emulsification technology has made remarkable progress, and extremely stable emulsions are now widely used in all industries. However, most of them use nonionic surfactants containing polyoxyethylene chains, anionic surfactants represented by fatty acid layer, cationic surfactants, and amphoteric surfactants as emulsifiers. In particular, many general consumers have concerns about safety.

Under these circumstances, research has recently begun on the use of natural polymeric substances, which are considered to be highly safe, as emulsifiers. However, natural water-soluble polymer substances have a smaller ability to reduce interfacial tension than the so-called ``surfactants'' such as the nonionic surfactants mentioned above, so their emulsifying power is relatively small, and In general, the emulsified particle size becomes coarse, about 10 μm, and the stability over time is poor. Furthermore, it is known that the emulsification state tends to improve when a water-soluble polymer substance is used in a concentrated aqueous solution system with a wetting agent, but this method limits the oil phase components and wetting agent that can be used, and The drawback is that the scope of application is narrow.

In view of these circumstances, the present inventors have conducted extensive research focusing on proteins among natural polymeric substances with high human safety.As a result, the present inventors have found that proteins are combined with specific components and dissolved in polyhydric alcohol. The present inventors have discovered that by adding an oil component to this, it is possible to produce an emulsion with fine particle size and good stability, leading to the completion of the present invention.

That is, the present invention provides one or more phospholipids or salts thereof, one or more proteins or salts thereof, and one or more polyhydric alcohols having two or more hydroxyl groups in the molecule. An emulsified composition containing seeds or more and an oil component; an emulsified composition in which the oil component is solubilized or uniformly dispersed in a polyhydric alcohol, or a homogeneous and fine emulsified composition obtained by further adding water to this emulsified composition. The present invention provides a stable oil-in-water emulsion composition having emulsified particles.

The emulsion composition obtained according to the present invention is a transparent or translucent viscous liquid or gel, and the oil-in-water emulsion composition to which water is added is an emulsion of milky white fine particles. These are emulsified compositions with fine particle size and good stability that cannot be achieved by the conventional polymer emulsification method of dissolving a polymer in water and then emulsifying and mixing an oil component.

The cause of this microparticulation is that phospholipids or their salts and proteins have a lower interfacial tension than the water-oil interface, which is polyhydric alcohol.
This is thought to be due to the rapid orientation and interaction at the oil interface.

The polyhydric alcohol used in the present invention is a water-soluble polyhydric alcohol containing two or more hydroxyl groups in the molecule.
-ru T・Example Eva, ethylene glycol, propylene glycol, L3-butylene glycol, 1,4-butylene glycol, dipropylene glycol, glycerin, and polyglycerin such as diglycerin, triglycerin, and tetraglycerin, glucose, maltose, These include maltitol, sucrose, fructose, xylitol, sorbitol, oltotriose, threitol, erythritol, starch decomposition axis, starch decomposition sugar ring alcohol, and one or more of these may be used.

The blending amount is 2 to 95% by weight (hereinafter simply referred to as %) of the emulsified composition comprising one or more phospholipids or salts thereof, a polyhydric alcohol, and an oil phase.

(The following is a blank space) The phospholipids used in the present invention are phospholipids extracted from plants such as soybeans, corn, peanuts, rapeseed, and wheat, egg yolks, animals such as cows, and microorganisms such as Escherichia coli, and include phosphatidic acid, phosphatidyl Glycerophospholipids such as glycerin, phosphatidylinositol, phosphatidylethanolamine, phosphatidylmonomethylethanolamine, phosphatidyldimethylethanolamine, phosphatidylcholine (lecithin), phos-7 atidylserine, bisphosphatidic acid, diphosph'7tidylglycerin (calciolipin), sphingomyelin, etc. Contains sphingophospholipids, and hydrogenated products of these are also used.

(Hereinafter, blank spaces) The proteins used in the present invention are usually proteins obtained from nature or their decomposition products, and have a molecular weight of 5000.
It's more than Dalton. Examples of these include: Soybean protein/wheat protein, glutelin, whey powder, soybean casein, soybean flour/fibroin, glucagon, collagen, gelatin, elastin, egg white lysozyme, amylase, fibrinogen, myosin, enolase, chymotrybium/gen , histone, actin, naratin 1
Mention may be made of hemoglobin, avidin, pepsin', growth hormone, albumin, globulin, myoglobin, casein-1-papain, β-galactosidase, insulin, lysozyme, and catalase. Similarly, it is also possible to use these acids, alkalis, and enzymatic decomposition products.

Substances that form salts when phospholipids and proteins are used as salts include inorganic bases such as lithium hydroxide, sodium hydroxide/potassium hydroxide, cesium hydroxide, and ammonium hydroxide; , basic amino acids such as ornithine and basic oligopeptides having them as residues, bases such as basic amines such as monoethanolamine, jetanolamine, and triethanolamine, inorganic acids such as hydrochloric acid and sulfuric acid, acetic acid, Citric acid, maleic acid
Organic acids such as fumaric acid, acidic amino acids such as glutamic acid and aspartic acid, and acidic oligopeptides having these as residues are used. The salt may be added in advance (by reacting to form a salt) or may be added separately and reacted during the manufacturing process of the emulsion composition to form a salt.

The pH of the phospholipid and protein salt aqueous solution may be any value, but it is preferable to avoid the isoelectric point of the protein if possible.

The blending amount of phospholipid or its salt and protein is 2-
In the range of 8 to 8:2, a significantly better emulsified composition can be obtained than when each is used alone. The weight ratio of the phospholipid or its salt, the protein or its salt, and the polyhydric alcohol having two or more hydroxyl groups in the molecule is in the range of 1=1 to 1000. If the amount of polyhydric alcohol is less than 1 to the total amount of phospholipid or its salt and protein or its salt, the phospholipid or its salt and protein will not be completely dissolved, and if it exceeds 1000, emulsion stability will deteriorate. .

Oils used in the present invention include animal and vegetable oils and fats such as beef tallow, squalane, olive oil, and rice bran oil; hydrocarbons; mineral oils such as liquid paraffin and petrolatum; isopropyl myristate; pentaerythribatol-tetra-2-ethylhexanate; Vitamin A
These oils are commonly used in the cosmetics, pharmaceutical, and food industries, such as ester oils such as banermitate and vitamin E acetate, and silicone oils such as methylphenyl silicone and dimethyl silicone.

It is desirable to adjust the total amount of polyhydric alcohol, phospholipid or its salt, and protein or its salt to 20% or more based on the oil content.

In addition to the above-mentioned essential components, the emulsified composition according to the present invention may include nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, drugs, ultraviolet absorbers, Preservatives, antioxidants, etc. may be mixed and added. Furthermore, alcohol, fatty acids, other water-soluble polymers, etc. may be added for the purpose of homogeneity stabilization and viscosity adjustment.

The emulsified composition of the present invention can be obtained by dissolving a phospholipid or its salt and a protein or its salt in a polyhydric alcohol or its aqueous solution, and gradually adding an oil component while stirring. In this case, it is preferable to perform a homomixer treatment, but a good emulsified composition can be obtained even with a weak stirring force such as manual stirring.

The emulsified composition obtained here is a homogeneous transparent or translucent gel or viscous liquid, so it can be used as it is, for example, in sun care jelly, beauty serum, and other oil-in-water emulsified compositions according to the present invention. can be obtained by mixing the emulsion composition described above and water. In this case, it is preferable to perform homomixer treatment. The oil-in-water emulsion composition obtained here has extremely excellent stability.

Depending on the purpose, water phase components commonly used in the cosmetics, pharmaceutical, food, and other industries may be added to the water, such as humectants, water-soluble vitamins, water-soluble preservatives, water-soluble drugs, and water-soluble polymers. You can also do it.

The quantitative relationship between the emulsion composition and the aqueous phase components can be selected from a very wide range, but usually the emulsion composition is 0.5 to 80%
parts, and about 995 to 2D parts of water.

The oil-in-water emulsion composition obtained here is a milky white viscous or low-viscosity liquid in which uniform fine particles are dispersed, so it can be used in cosmetics such as emulsions, creams, foundations, etc. even in its original form. It can be suitably used in all fields such as toiletry products such as shampoo and conditioner, pharmaceuticals such as urea cream and acne cream, and food products such as mayonnaise.

In addition, there is no problem in adding other water-soluble polymers, drugs, surfactants, powders, etc. in order to stabilize homogeneity, adjust viscosity, or impart medicinal efficacy.Hereinafter, the present invention will be described in Examples and Comparisons. This will be explained in more detail by way of example. The present invention is not limited thereby.

Examples 1-9. Comparative Examples 1 to 7 Protein, phospholipid, polyhydric alcohol, ion-exchanged water, and oil were blended in the composition and amounts shown in Table 1, and treated with a homomixer at 70°C to make an emulsified composition. ,. Further, 10 times the amount of water was added to this emulsified composition while stirring at room temperature to prepare an oil-in-water emulsified composition. The states of the emulsified composition and oil-in-water emulsified composition were observed, and their characteristic values were measured, and the results are shown in Table 1.

Note that the numbers for each component are weight %.

As is clear from Table 1, when protein or phospholipid is used alone as an emulsifier, (comparative example) ~3.5~7
), a stable emulsion was not obtained, and even in Comparative Example 5.6 where an emulsion was obtained, the emulsion particle size was 10 μm or more and the oil-in-water emulsion composition was separated. Furthermore, even when a combination of protein and phospholipid was used as an emulsifier, a stable emulsified composition could not be obtained if the amount of polyhydric alcohol was small (Comparative Example 4).

On the other hand, for Examples 1 to 9 according to the present invention,
At any level, a very good transparent or translucent viscous liquid or gel is obtained.Furthermore, the oil-in-water emulsion composition obtained by adding water is stable with very fine particles dispersed. Emulsion Table 14 (■) The condition of the oil-in-water emulsion composition was evaluated based on the following criteria after being left for one day.

◎ Emulsified particle size 1μ or less Ol~5μ △ 5~10μ × wμ or more (hereinafter margin) Weight% (A) Soybean lecithin &0
Sodium caseinate 1.0 Maltitol (50% aqueous solution) 200 1.3 -Butylene glycol lα0 Sodium hyaluronate 01(B) Liquid paraffin 4αO olive oil
2Z5 Glyceryl Tristearate 3.0 Vitamin E Acetate
α5 preservative 0
．． 5 fragrances
Stir α4(A) phase thoroughly at 70°C,
A solution of phase (B) at 70° C. was added to phase (A) with stirring. This mixture was treated with a homomixer and cooled with stirring to obtain an aqueous cosmetic jelly. This beauty jelly is a viscous, slightly fluid, transparent gel-like emulsion that is highly safe for the skin and has excellent stability over time.When applied to the skin, it spreads very easily. It had the characteristic of being used over a wide range in small amounts.
-Butylene glycol 5.0 soybean protein decomposition product (molecular weight 10,000) b.

Water-soluble flagen 1.0 Egg yolk lecithin hydrogenated product 05 Calciolipin
0.5 allantoin
02 Sodium hydroxide 0.05 (
B) Liquid paraffin 1α0 Jojoba oil 5.0 Pentaerythritol-tetra-2-ethylhexanoate 5.0 Vaseline 5.0 Ethinyl estradiol α1 Preservative
. 4 Fragrance α3 (0
) Purified water 45.75 Sodium alginate α1 xanthine gum
According to the manufacturing method of α1 Example 1o, (
An emulsion composition was obtained from the A) phase and the (B) phase, and the temperature was set at 70°C.
Aqueous thickener solution prepared separately and kept at 70°C (0
) phase and then cooled to obtain a nutritional emulsion of oil-in-water emulsion. The viscosity of this emulsion is 4"L at 30'C.
IQOPs, with emulsified particle size of about 1 to 3 μm, stable and familiar feel 0 Example Pressure Suncare Cream Weight % (A) Diglycerin 20.0
Sorbitol (70% aqueous solution) a.

Fructose zO soy lecithin 2-0 egg albumin
3゜globulin Lo
CB) Liquid paraffin 20.
0 Isopropyl myristate 100 Vaseline 5.0 Stearyl alcohol 5. OP A B A
2.0 preservative 05 fragrance
Fee α
3(0) Purified water
IELO Hydroxyethyl Cellulose α2(D) Mixed Powder
LO titanium dioxide
A sun care cream was obtained according to the manufacturing method of Example 20. At this time, the (0) phase was used as a diluted phase after the (D) phase was subjected to a dispersion homomixer treatment at 70°C. This sun care cream has a 25°C hardness of Suri, is slightly transparent, and has a highly stable oil-in-water emulsion composition with an emulsion particle size of approximately 1 to 3 μm, making it suitable for use under sunlight. It was possible.

Patent applicant Shiseido Co., Ltd.

Claims (1)

[Claims] 1. One or more phospholipids or salts thereof; one or more proteins or salts thereof;
Emulsified composition characterized by containing one or more water-soluble polyhydric alcohols having at least three hydroxyl groups, and an oil component 2-1] One or more types of lipids or salts thereof; ,
An emulsified composition containing one or more proteins or salts thereof, one or more water-soluble polyhydric alfurs having two or more hydroxyl groups in the conidia, and an oil component, and water. An oil-in-water emulsion composition comprising: (Margin below)