JPS60202807A - Agent for growing hair - Google Patents
Agent for growing hairInfo
- Publication number
- JPS60202807A JPS60202807A JP5839084A JP5839084A JPS60202807A JP S60202807 A JPS60202807 A JP S60202807A JP 5839084 A JP5839084 A JP 5839084A JP 5839084 A JP5839084 A JP 5839084A JP S60202807 A JPS60202807 A JP S60202807A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- hair
- peptide
- hair growth
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004209 hair Anatomy 0.000 title abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- 239000000126 substance Substances 0.000 claims abstract description 13
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 claims abstract description 11
- 101800003906 Substance P Proteins 0.000 claims abstract description 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 6
- 239000002253 acid Substances 0.000 claims abstract description 5
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical group OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims abstract description 4
- 125000000539 amino acid group Chemical group 0.000 claims abstract description 4
- 108010057380 substance P-like peptides Proteins 0.000 claims abstract description 4
- 239000002777 nucleoside Substances 0.000 claims abstract description 3
- 102100024304 Protachykinin-1 Human genes 0.000 claims abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims abstract 2
- 230000003779 hair growth Effects 0.000 claims description 24
- 230000001595 contractor effect Effects 0.000 abstract description 3
- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 239000007787 solid Substances 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 2
- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 abstract description 2
- 230000036772 blood pressure Effects 0.000 abstract 1
- 210000003405 ileum Anatomy 0.000 abstract 1
- 230000001976 improved effect Effects 0.000 abstract 1
- 102400000096 Substance P Human genes 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000004531 blood pressure lowering effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 235000002492 Rungia klossii Nutrition 0.000 description 1
- 244000117054 Rungia klossii Species 0.000 description 1
- 241001247145 Sebastes goodei Species 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical class CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000810 peripheral vasodilating agent Substances 0.000 description 1
- 229960002116 peripheral vasodilator Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- -1 salicylic acid Chemical class 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000008257 shaving cream Substances 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は発毛、育毛を促進し且つ脱毛を防止する新規な
育毛剤に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel hair growth agent that promotes hair growth and growth and prevents hair loss.
更に詳しくは、本発明は有効成分としてサブス、々 ・
ノ −ｔ ｐ 易 ＩＣシト σ）−鼻ＩＦ＝；ｆ’／
Ｔ）Ｘ−Ｐｈｅ−Ｐｈｅ−Ｇｌｙ−Ｌｅｕ−Ｍｅｔ −
ＮＨ３（１）ｃ式中、Ｘはピログルタミン酸残基（ｐＧ
Ｉ ｕ ）、又はアミノ酸残基の７〜！個より々るペプ
チド又はヌクレオシドを示す）で表わさ九るサブスタン
スＰ様ペプチドならびにその酸付加塩の少くとも１つを
含有することを特徴とする育毛剤を要旨とするものであ
る。More specifically, the present invention uses subs, etc. as active ingredients.
No -tp Easy IC σ)-Nose IF=;f'/
T)X-Phe-Phe-Gly-Leu-Met-
NH3(1)c In the formula, X is a pyroglutamic acid residue (pG
Iu), or 7~! of amino acid residues! The subject matter is a hair growth agent characterized by containing at least one substance P-like peptide (indicating different peptides or nucleosides) and its acid addition salt.
本発明の育毛剤の有効成分化合物のうち、サブスタンス
Ｐ （ａｕｂｓｔａｎｅｅ Ｐ）は、次の構造式％式％
（）
で表わさ几て７１個のアミノ酸残基からなる公知のウン
デカペプチドである（「医学のあゆみ」第１０／巻第グ
号／７９’〜／Ｉ！頁（昭和！２年７月２３日発行）参
照）。このサブスタンスＰは近時、求心性−次知覚二二
一ロンの神紅伝達物質としてその生理的意義が明らかに
さｎつつある生理活性ペプチドである。サブスタンスＰ
は回腸収縮作用、血圧降下作用などの生理作用、もしく
は薬理作用を有することが知らｎている。一方、サツス
タンスＰの生理、薬理作用を増大するために、種々なサ
ブスタンスＰ誘導体すなわちサブスタンスＰ様ペゾチド
が合成され、これら誘導体が顕著な回腸収縮作用乃至血
圧降下作用を有することが認めらｎでいる（前出「医学
のあゆみ」並びに特開昭ｊ３−／ダ７０４弘号、特開昭
１３−／４７７０ぶ！号、特開昭１３−１４１７０９２
号及び特開昭１３−１４１７０２３号公報参照）。Among the active ingredient compounds of the hair growth agent of the present invention, substance P (aubstanee P) is a known undecapeptide consisting of 71 amino acid residues represented by the following structural formula (%) () (Refer to "The History of Medicine" Volume 10/No. G/79'-/I! pages (published on July 23, 1929)). Substance P is a physiologically active peptide whose physiological significance has recently been clarified as an afferent-subsensory transmitter. Substance P
is known to have physiological or pharmacological effects such as ileal contraction and blood pressure lowering effects. On the other hand, various substance P derivatives, namely substance P-like pezotides, have been synthesized in order to enhance the physiological and pharmacological effects of sustance P, and these derivatives have been found to have significant ileal contracting and blood pressure lowering effects. (The above-mentioned ``Medical History'' as well as JP-A No. 3-/DA704 Hiroshi, JP-A No. 13-/4770-BU!, JP-A-13-1417092)
(Refer to Japanese Patent Application Laid-open No. 1417023/1983).
本発明者は、前記の式（ＩＤのサブスタンスＰ１ならび
に一般式（１）のサブスタンスＰ様ペゾチドが皮膚に塗
着した場合には、局所の血流増加作用を有し、発毛ある
いは育毛に優ｔ″Ｌ次効果を奏することを発見して本発
明を完成したものである。The present inventors have discovered that when Substance P1 of the formula (ID) and Substance P-like pezotide of the general formula (1) are applied to the skin, they have an effect of increasing local blood flow and are effective in hair growth or hair growth. The present invention was completed by discovering that a t″L-order effect is produced.
一般式（Ｉ）のサブスタンスＰ様ペゾテドの例には。Examples of substance P-like pezoted of general formula (I) include:
次の第１表に示さｎたサブスタンスＰ誘導体がある。There are substance P derivatives shown in Table 1 below.
上記のサブスタンＰ及びサブスタンスＰ様ペゾチドは、
塩酸、硫酸の如き無機酸又は酪酸、プロピオン識の如き
有機酸との付加塩の形でおることもできる。The above substance P and substance P-like pezotide are
It can also be in the form of an addition salt with an inorganic acid such as hydrochloric acid or sulfuric acid or an organic acid such as butyric acid or propionic acid.
以下、本発明の構成について詳述する。本発明で用いら
れるサブスタンスＰ及びサブスタンＰ様ペゾチドは適当
な液体又は固体又は半固体媒質に溶解又は分散して用い
られ、その配合量（濃度）は通常ｏ、ｏ ｏ ｚ％〜０
．０コチ（電量／谷重）であるのが好ましい。Hereinafter, the configuration of the present invention will be explained in detail. Substance P and substance P-like pezotide used in the present invention are used after being dissolved or dispersed in a suitable liquid, solid or semi-solid medium, and the blending amount (concentration) thereof is usually o, o o z% to 0
．． It is preferable that it is 0 kochi (amount of electricity/tani weight).
本発明の育毛剤有効成分化合物と配合される担体として
は、従米知られる育毛剤又は養毛剤又は化粧品に慣用さ
れる物質又はその混合物であることができ、例えば水、
エタノール、を水エタノール、公知のクリーム基剤、油
性基剤であることができる。製剤に肖っては、栄養学的
起源からビタミン類、アセチルコリン誘導体のような末
梢血管拡張剤、サリチル酸のような角質溶解剤、トウガ
ラシ等の皮膚機能光進剤、保湿剤、おるいは殺菌次に試
験例、実施例について本発明の詳細な説明する。本発明
はこれによシ限定されるものではない。The carrier to be mixed with the active ingredient compound of the hair growth agent of the present invention may be a known hair growth agent or hair tonic, or a substance commonly used in cosmetics, or a mixture thereof, such as water,
Ethanol, water, ethanol, known cream bases, oil bases can be used. In terms of formulations, they include vitamins of nutritional origin, peripheral vasodilators such as acetylcholine derivatives, keratolytic agents such as salicylic acid, skin function enhancers such as chili pepper, moisturizers, and disinfectants. The present invention will be explained in detail with reference to Test Examples and Examples. The present invention is not limited to this.
実施例／
本発明Ｍ効成分ペプチドとしてサブスタンスＰの１ｏｒ
ｒｌにエタノールｔ１及びグリセリンの００ｊ１ｔ 加
えて浴かしｍ後、水會加えて全容１０ｒｘｌとすると０
．／ ％のサブスタンスＰｋｔむローション・タイプの
育毛剤を得る。Example/1or of substance P as the active ingredient peptide of the present invention M
Add 00j1t of ethanol t1 and glycerin to rl, and after bathing m, add water to bring the total volume to 10rxl, then 0
．． / Obtain a lotion type hair growth agent containing % substance Pkt.
試験例／ マウス育毛試験
０．１％の各ｉペプチドを含むローションΦタイプ育毛
剤を実施例１と同様に調製してマウスの皮膚に塗り育毛
実験′ｇｔ実施した。育毛剤の調製法は実施例／と同様
でるるか、配合されるペプチドとしてサブスタンスＰ並
びに第１表に示すペプチドの中で代表的なサブスタンス
Ｐ６−１□、サブスタンスＰ ４−１１及びＭＨ−１４
Ａｌｔ−用いて以下の第２表に示す４／一種類の育毛剤
試料と、ペプチド無添加の対照薬剤とＷｅ［ｉｌｌ！Ｌ
、供試試料とじ九。Test Example/Mice Hair Growth Test A hair growth lotion Φ type hair growth agent containing 0.1% of each i-peptide was prepared in the same manner as in Example 1 and applied to the skin of a mouse to carry out a hair growth experiment. The preparation method for the hair growth agent is the same as in Examples/1, or the peptides to be blended include substance P, as well as substance P6-1□, substance P4-11, and MH-14, which are representative of the peptides shown in Table 1.
Using Alt-4/one type of hair growth agent sample shown in Table 2 below, a control drug without peptide addition, and We[ill! L
, Test sample binding 9.
１群６匹の２０週令０．Ｈ系雄性マウスの背部毛を刈シ
取り、その部所に翌日よりｔ日Ｖ回＃３週間連続で育毛
剤試料全１回ｊ０μを塗布し友。最終投与の翌日、投与
部位の一定面積（／、ｔｍＸコ、−七刺毛し、採取した
毛の重量（■）を測定し、育毛作用全検討した。20 weeks old, 6 animals per group, 0. The hair on the back of an H-strain male mouse was shaved off, and from the next day, the hair growth agent sample J0μ was applied once every day for 3 weeks. On the day after the final administration, a certain area (/, tmX, -7 hairs) of the administration site was pricked, the weight (■) of the collected hair was measured, and the entire hair growth effect was examined.
刺毛はマウス會エーテルで麻酔させた後、シェービング
クリーム全塗布し、安全力ξソリで行った。採取した毛
はビーカー内で水洗後、Ｐ取し、１．１℃でλ参時間乾
燥し、更に温室内にコグ時間放置後の重量を測定し発毛
量とし次。After the hair was anesthetized with mouse ether, shaving cream was applied completely and the hair was sledged with safety force. The collected hair was washed with water in a beaker, then P was removed, dried at 1.1°C for a time of λ, and then left in a greenhouse for a time of λ, and the weight was measured to determine the amount of hair growth.
試験結果 次表に示す。Test results Shown in the table below.
ここに得られ九発毛量について、育毛剤１〜ｄのそれぞ
れをペプチド無投与群ｅとの間で分散分析を行った結果
、第４を表に示す過多いずれも有意（Ｐ＜０．０ ／）
となり、第２表に示す参種のベゾチドのすべてが育毛作
用上回することが確認され丸。Regarding the amount of hair growth obtained here, as a result of performing variance analysis between each of hair growth agents 1 to d and the peptide non-administration group e, all of the excesses shown in the table 4 were significant (P<0.0 /)
It has been confirmed that all of the bezotides listed in Table 2 have superior hair growth effects.
よってサブスタンスＰ及び一般式（Ｉ）で表わされるサ
ブスタンスＰ様ペゾチドは育毛作用ｔＶすることがここ
に証明され几。Therefore, it has been proven here that Substance P and Substance P-like pezotide represented by the general formula (I) have a hair growth effect.
第 ｌ 表 申Ｉ 二 ／ チ １岨”意Table l Shin I 2 / Chi 1 岨” meaning
Claims (1)
Ｉ） Ｘ−Ｐｈｅ −Ｐｈｅ −Ｇｌ ｙ −Ｌｅｕ −Ｍｅ
ｔ −ＮＨ３（１）（式中、Ｘはピログルタミン酸残
基（ｐＧＩｕ）、又はアミノ酸残基の７〜５個よりなる
ペプチド又はヌクレオシドを示す）で表わさ几るサブス
タンスＰ様ペプチドならびにその酸付加塩の少くとも１
つを含有することを特徴とする育毛剤。 ２ サブスタンスＰ１あるいはサブスタンスＰ様ペプチ
ドが酸付加塩である特許請求の範囲第１項記載の育毛剤
。[Claims] t Substance P as an active ingredient and the following general formula (
I) X-Phe-Phe-Gly-Leu-Me
Substance P-like peptide represented by t-NH3(1) (wherein X represents a pyroglutamic acid residue (pGIu) or a peptide or nucleoside consisting of 7 to 5 amino acid residues) and acid addition salts thereof at least 1 of
A hair growth agent characterized by containing: 2. The hair growth agent according to claim 1, wherein substance P1 or substance P-like peptide is an acid addition salt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5839084A JPS60202807A (en) | 1984-03-28 | 1984-03-28 | Agent for growing hair |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5839084A JPS60202807A (en) | 1984-03-28 | 1984-03-28 | Agent for growing hair |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS60202807A true JPS60202807A (en) | 1985-10-14 |
Family
ID=13083014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5839084A Pending JPS60202807A (en) | 1984-03-28 | 1984-03-28 | Agent for growing hair |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60202807A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005107688A1 (en) * | 2004-04-26 | 2005-11-17 | Immuneregen Biosciences, Inc. | Inducing and maintaining hair color |
| WO2009085236A3 (en) * | 2007-12-21 | 2009-11-12 | Immuneregen Biosciences, Inc. | Compositions and methods of using substance p. analogs |
-
1984
- 1984-03-28 JP JP5839084A patent/JPS60202807A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005107688A1 (en) * | 2004-04-26 | 2005-11-17 | Immuneregen Biosciences, Inc. | Inducing and maintaining hair color |
| WO2009085236A3 (en) * | 2007-12-21 | 2009-11-12 | Immuneregen Biosciences, Inc. | Compositions and methods of using substance p. analogs |
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