JPS6025448A - Electrode device for measuring ion concentration in liquid - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to an ion saddle for measuring the concentration of various ions in blood, as well as the concentration of ions in solutions such as water for general use and chemical reaction. This invention relates to a pole device for measuring temperature.

Structure of the conventional example and its problems The measurement of ion concentration in bath liquid is often carried out in various industrial water concentration standards 1IIU or in the process of chemical reactions. It is well known that in recent years, in the field of clinical medicine, the measurement of ion concentration in dishes has been carried out very frequently, and is also used for various diseases such as diabetes screening. It is.

The measurement of ion 1 atrocities has been carried out using the flame method and the illumination method since the beginning.
↑In November, the f-on selective electrode has a general
] I'm bored. As a reference electrode used in pair with this ion d-selective electrode, a 1-rich, saturated 4-yoko electrode or a 6J)-silver chloride electrode is used. But unfortunately,
A pair of these 1) (≧ can be used as is, for example, to determine the concentration of ions in blood,)
When using 11, it becomes 1B1/1C: There is a tendency to slow down the response speed of the electric 111, or to speed up the reproducibility of measurement1.
I feel noisy. Therefore, it is often necessary to remove the f-electrode between measurements and then clean or replace it15;
The current situation is that the number of points t and q required is 3%, and continuous measurement over a long period of time is difficult.

OBJECTS OF THE INVENTION The present invention overcomes the drawbacks of conventional electrode methods, even when used for long periods of time to measure blood ion concentrations.
(The purpose is to provide a 1u electrode device for measuring ion concentration in liquid that can prevent SE blood from occurring on the 11th surface.

Structure of the Invention In order to achieve the above object, the present invention provides a part of the liquid path for the test liquid (with an ion-selective surface, a polar sensitive surface, and a polar sensitive surface facing the sample chamber). At least one of the γη junction surfaces of the reference electrode is disposed, and a rotor that contacts the sensitive membrane surface of the ion-selective electrode or the liquid junction surface of the reference electrode is provided in the sample chamber. An electrode for measuring ion concentration in a liquid is provided, which is formed into a 1·N structure so as to be rotated Wmb by a drive 1iIJ device.

According to the above configuration, the sensitivity of the ion-selective electrode 'N i
Among the liquid junction surfaces of the Mi and reference electrodes, the one that is more susceptible to the effects of coagulation when used to measure ion concentration in blood (generally the sensitive membrane surface of the ion-selective electrode) Since blood clotting can be prevented by the rotor, the need for maintenance and inspection of the electrodes is reduced, and the continuous ion concentration in the blood becomes a QJ function.

DESCRIPTION OF EMBODIMENTS Embodiment 1 of the present invention will be described in detail below with reference to accompanying drawings.

X, on the 1fji side, the ion concentration in the liquid according to the example of Kinoe t, ttj does not show the entire collection of - in the liquid ion concentration side, and the first
In the figure, (1) is the ion 4 that has been used with the lead wire (2).
Choice 1f i ≧, 1st edition), this ion selectivity? ri1i”
The sample chamber (is n) has a sensitive membrane surface (7) facing the sample chamber (3) that forms the liquid channel (sampling) along with the injection channel (4) for the liquid and Ura and Yamaji (5). Above the chamber (3) there is a junction surface (see reference with 11) 1 or jtii (+
+) is provided, and both 1'd Q ++, ) ()
The cells Qυ are inserted and held in the lower and upper ends of the plastic cell (Ill).The lower and upper ends of the cell Qυ are respectively inserted and held.
'4 and upper M O, I take (J' keraderi, 6
The lid 0 is used to prevent both poles (υ(II)) from moving in the same direction. In the sample chamber (3), there is a sensitive A magnetic rotor 04 that can contact the membrane surface (7) with a sufficient contact area is arranged.

The surface of the magnetic rotor α→ is made of abrasive materials such as resin, SiC, and Al2O3.

Alternatively, it is coated with an abrasive cloth, which can prevent the magnetic rotor from rusting and improve its abrasive effect. The magnetic rotor 0 lead is rotationally driven around the vertical axis by a drive device Qlli provided below the sample chamber (3). The drive device ttS is housed in a container (0) attached to the lower lid (), and consists of a magnetic body αQ for generating a rotating magnetic field and a motor (0'/) for rotationally driving this magnetic body H. It is configured.

As the ion selective electrode (1), generally known ones can be used, but an internal liquid type one as shown in FIG. 2 cannot be applied to the configuration of the embodiment shown in FIG. 1. In other words, the internal liquid type has a cylinder (101) made of glass or other material equipped with a glass sensitive membrane (100) at the lower end that is sensitive to changes in ion concentration, and is filled with hydrochloric acid or An electrolytic solution (102) such as a phosphate aqueous solution and an Amagi electrode (108) with a lead wire (104) made of mercury, Amagi (Hg2C12) and a potassium chloride solution are placed in one end of the cylindrical body (IOI). Cap (105)
Install and configure. However, this internal liquid type has rr! , and dissolution (102), the device must be used while standing up as shown, which is extremely inconvenient if it is desired to be used while tilted or inverted. In addition, glass sensitive membrane (Zoo)
has a curvature, so the configuration shown in FIG. 1 cannot ensure a sufficient contact surface with the magnetic rotor 04, and is not suitable for this embodiment.

Therefore, in this embodiment, a solid-state type ion selectivity electrode as shown in FIG. 8 was used. In Figure 8, 01
is a glass sensitive membrane sliced into thin discs with a diameter of 8 to 80 μm and a thickness of 50 to 500 μm.

A 10% silver fluoride aqueous solution was applied to one side of the glass sensitive film and dried several times to form a silver fluoride layer. After leaving it for a day and night, it was immersed in a 6% lithium chloride solution. After leaving it for about 20 hours, the silver fluoride layer was replaced with a silver chloride layer (2) from which electromotive force could be extracted more stably. This is washed with water and then heat-treated in argon or nitrogen at 800° C. for 2 hours to improve the adhesion between the glass sensitive film 01 and the silver chloride layer Kl. After that, a layer of silver chloride (
Connect the lead wire (2) to e) using conductive resin QO such as silver paint, and then apply the resin from above)
to make a rod-shaped glass electrode. The sensitive film surface (5) of the glass sensitive film 01 is well polished in order to stably extract the electromotive force, and its flatness is increased to improve contact with the magnetic rotor (I→). The typical sensitive film 01 has a glass composition of 6g5io□28Li.
20.2Cs20-5BaO-2La, 05 is known, and in the case of sodium ion, 7t S 1O
2-i BAI203-11 When NaO is a potassium ion, 70SiO□-8A120. -27Na2
0 is known respectively. In addition, as an electrode for chloride ions, a glass sensitive membrane (instead of +1, AlCl (8
It is common to use a ceramic sensitive film obtained by pressure-molding a material with a composition of 0ωt%)-AgS (20ωt%) at 250°C, and connect lead wires to this using a conductive resin. , and then solidified with resin to form a solid rod-shaped electrode.

On the other hand, as shown in Fig. 4, the reference electrode (8) is a glass cylinder equipped with a pin hole Q4 as a liquid junction at the tip, and an electrolytic solution made of an aqueous solution of potassium chloride or the like is used to extract the electromotive force. A silver-silver chloride electrode (c) having a lead wire (4) and a silver-silver chloride electrode (c) are respectively placed in the electrode and covered with a cap. Note that the liquid junction has a pinhole (
Instead of c), a sleeve type using glass grinding or a fiber type using fiber can be used as well, and a Teflon container can be used instead of the glass cylinder e+.
The liquid junction may be of a type provided with porous Teflon.

fJ, without using the sample solution of large ER, the apparatus of this example
In order to perform continuous analysis of ion concentration using F7', the sample liquid sent to the device per unit time, such as blood, should be made smaller. When the speed of blood flowing through (6) becomes slower, the responsiveness of both electrodes +1) and +8) deteriorates. In order to avoid this, in this embodiment, as shown in FIG. In addition, in order to quickly carry out these simple tests, we also designed a sample chamber (3) with a large space.
p, '4 plane and magnetic rotor. Blood exchange in the sample chamber (3) can be carried out quickly by making the distance %i (d) of the gap between the tube and the surface of the tube smaller than the aforementioned diameter (D). As a result, both electrodes (υ(
8) The decrease in response speed can be prevented.

The electric garden device configured as described above operates as follows.

That is, during the operation of injecting test blood from the injection path (4) using a liquid feed pump (not shown) or the like, and at the same time taking out the blood from the sample chamber (3) from the inflow path (5), the ion selectivity The concentration of a predetermined ion in the blood is measured by measuring the potential difference generated between the electrode (1) and the reference electrode (8). At this time, the magnetic body θ0, which is rotated by the motor 0 installed outside the cell (lυ), rotates while attracting the magnetic rotor (→) in contact with the sensitive membrane surface (7) of the ion-selective electrode. As a result, the sensitive membrane surface (7) of the ion-selective 1-electrode (1), which is more susceptible to the adverse effects of blood coagulation, is always kept clean, so the device can be used for a long period of time.

Effects of the Invention As described above, in the electrode device for measuring ion concentration in liquid according to the present invention, 14. Since the device can be kept clean at all times by bringing the side that is more likely to receive ions into contact with the rotating rotor, it can be used continuously for a long period of time even when measuring blood ion concentration.

[Brief explanation of the drawing]

FIG. 1 is a vertical cross-sectional view showing an electrode device for measuring ion concentration in liquid according to a practical example of the present invention, and FIG. 8 is a vertical cross-sectional view, not showing a solid-state ion-selective electrode applied to the same device, FIG. 4 is an IiM cross-sectional view showing a reference electrode applied to the same device, and FIG. FIG. (S...Ion selective electrode, (3)...Sample chamber, (
6)...Liquid path. (7)...Sensitive membrane surface 2 (8)...Reference m ti! i
i, +11...liquid junction surface, 0xu...magnetic rotor, (1 field...driver, H...sensing 11ψ agent
Yoshihiro MorikiFigure 1Figure 2Figure 3Figure 4

Claims (1)

[Claims] 1. The ion selection 1 tube 1'1. ': NM sensitivity 19+
At least one of the membrane surface and the liquid junction surface of the reference electrode is disposed, and the other is disposed so as to face the liquid path, and the membrane surface of the ion selective electrode or the reference electrode is disposed in the sample chamber. An electrode device for measuring ion concentration in a liquid, comprising a rotor in contact with a surface of a liquid junction, and the rotor is rotationally driven by a drive device. 2. The rotor is constituted as a magnetic rotor, and the magnetic rotor is rotationally driven by a rotational field formed by a rotating magnetic field generating device "direction" disposed outside the sample chamber as the drive device. Claim 1 structured as follows:
r) The electrode assembly for measuring ion concentration in liquid as described in (8) The ion-selective electrode is arranged so that the sensitive 1 return surface faces the sample chamber, and the liquid junction surface of the reference electrode is The electrode device for measuring ion concentration in liquid according to item 1 or 2, which is arranged so as to face a part of the liquid path other than the sample chamber, and is made by JR. R0 4. The short length of the prototype formed between the wall surface of the sample chamber and the surface of the rotor is
For measuring ion concentration in a liquid according to any one of the claims 1 to 3, the diameter of i is smaller than the diameter i = 74! :tii X inside 11°5,
4-k il"F +i blue, in which the rotor surface is followed by a tree j, 11', abrasive side or Uf abrasive cloth,
The electrode device for measuring ion concentration in a liquid according to any one of Items I to 4 of Item 4 of Item 4 of Item 4 of Item 4. 6. The ion selectivity X! 1jf5～Li:11
F(ζ type electric(・1i5 constituted IJ(Claims 1 to 5): 'ii4. 'f u'
BaO-2La20. Composition 17J 'J
P E1 equipped with a sensitive membrane made of laminate glass
'Ion H+ in the liquid according to claim 6, :) j
Electrode device for fraud. 8. The ion i”lU selection FJi ftj 1% is
'/I 5i02-18A1203・11Na20
4-The electrode device for measuring ion density in liquid according to item 6 under the category of reading. 9. The ion selectivity iff, the pole is 70Si02-8
A12 (J3.27Na, 0) Features: 1: The ion concentration in the liquid iit! , the ion-impairing “i!” pole is AgC1 (80ω
[%)-AgS (20 ωt%), comprising a sensitive [S11