JPS60352B2 - Stabilization method of uroganic acid aqueous solution - Google Patents
Stabilization method of uroganic acid aqueous solutionInfo
- Publication number
- JPS60352B2 JPS60352B2 JP16636379A JP16636379A JPS60352B2 JP S60352 B2 JPS60352 B2 JP S60352B2 JP 16636379 A JP16636379 A JP 16636379A JP 16636379 A JP16636379 A JP 16636379A JP S60352 B2 JPS60352 B2 JP S60352B2
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- sodium
- acid
- uroganic
- urocanic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007864 aqueous solution Substances 0.000 title claims description 15
- 239000002253 acid Substances 0.000 title claims description 5
- 230000006641 stabilisation Effects 0.000 title claims 2
- 238000011105 stabilization Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 title description 3
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 claims description 19
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 claims description 17
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
- 239000011734 sodium Substances 0.000 claims description 10
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- 159000000001 potassium salts Chemical class 0.000 claims description 4
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical class OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 8
- 238000002845 discoloration Methods 0.000 description 6
- 235000019832 sodium triphosphate Nutrition 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 238000005259 measurement Methods 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004649 discoloration prevention Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000021148 sequestering of metal ion Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
【発明の詳細な説明】
本発明は、ウロカニン酸水溶液の安定化法に関するもの
で、詳しくはウロカニン酸のアルカリ水溶液に、トリポ
リリン酸又はテトラポリリン酸のナトリウム及び／又は
カリウム塩の１種又は２種以上を０．０１〜１．の重量
％（以下、％は重量％を表わす）配合することにより、
ゥロカニン酸水溶液が光、熱、空気などによって経時的
に黄褐色へ変色することを防止し、安定な状態でウロカ
ニン酸水溶液を調整するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for stabilizing an aqueous solution of urocanic acid, and more specifically, one or two sodium and/or potassium salts of tripolyphosphoric acid or tetrapolyphosphoric acid are added to an alkaline aqueous solution of urocanic acid. The above is 0.01 to 1. By adding % by weight (hereinafter % means % by weight),
This prevents the urocanic acid aqueous solution from turning yellowish brown over time due to light, heat, air, etc., and prepares the urocanic acid aqueous solution in a stable state.
従来より、ウロカニン酸は天然に広く存在し、人体の汗
の成分でもあり、紫外線吸収効果があることが知られて
いるが、水への溶解性が悪いためゥロカニン酸単独で化
粧品等に配合、利用することは困難である。Traditionally, urocanic acid exists widely in nature, is a component of human sweat, and is known to have an ultraviolet absorption effect. It is difficult to utilize.
したがって従来はウロカニン酸の水への溶解性を高める
手段として強塩基であるカセイソーダや弱塩基であるト
リェタノールアミンなどとの中和による塩の形で利用さ
れることが多い。しかしながら、このような塩基で中和
したウロカニン酸水溶液は、経時的に光や熱や空気によ
り黄褐色への変色が著しく促進される。Therefore, conventionally, as a means of increasing the solubility of urocanic acid in water, it has often been used in the form of a salt obtained by neutralizing it with a strong base such as caustic soda or a weak base such as trietanoamine. However, an aqueous solution of urocanic acid neutralized with such a base significantly accelerates discoloration to yellow-brown by exposure to light, heat, or air over time.
そこで本発明者等は、このような変色を防止すべく鋭意
研究の結果、トリポリリン酸又はテトラポリＩＪン酸の
ナトリウム及び／又はカリウム塩の１種または２種以上
を０．０１〜１．０％配合せしめることによりウロカニ
ン酸による変色の防止を可能にした安定なゥロカニン酸
水溶液の製法を完成したものである。Therefore, as a result of intensive research in order to prevent such discoloration, the present inventors have found that one or more sodium and/or potassium salts of tripolyphosphoric acid or tetrapolyphosphoric acid are added in an amount of 0.01 to 1.0%. A method for producing a stable aqueous solution of urocanic acid has been completed, which makes it possible to prevent discoloration caused by urocanic acid.
本発明に使用されるトリポリリン酸ナトリウム又はテト
ラポリリン酸ナトリウムはいずれも「食品添加物公定書
」に記載されている物質で、金属イオン封鎖能、分散作
用、緩衝作用、保水性などの性質を有し、広く利用され
ており、各々の安全性も確認されている。Both sodium tripolyphosphate and sodium tetrapolyphosphate used in the present invention are substances listed in the "Food Additives Official Standards" and have properties such as metal ion sequestering ability, dispersion effect, buffering effect, and water retention. However, they are widely used and their safety has been confirmed.
トリポリリン酸塩及びテトラポリリン酸塩の添加量は０
．０１〜１．０％が好ましい。０．０１％以下の場合に
は添加による効果が充分ではなく、１．０％以上になる
と低温において、ウロカニン酸が析出することがあり、
また、効力も弱まる。The amount of tripolyphosphate and tetrapolyphosphate added is 0.
．． 01-1.0% is preferable. If it is less than 0.01%, the effect of addition will not be sufficient, and if it is more than 1.0%, urocanic acid may precipitate at low temperatures.
It also becomes less effective.
本発明の方法は、ウロカニン酸ナトリウム水溶液又はゥ
ロカニン酸トリェタノールアミン水溶液にトリポリリン
酸又はテトラポリリン酸のナトリウム及び／又はカリウ
ム塩を０．０１〜１．０％配合するものである。In the method of the present invention, 0.01 to 1.0% of sodium and/or potassium salts of tripolyphosphoric acid or tetrapolyphosphoric acid are added to an aqueous solution of sodium urocanate or trietanoamine urocanate.
次に、本発明によって得られるウロカニン酸水溶液の色
調安定度について、トリポリリン酸ナトリウム及びテト
ラポリリン酸ナトリウムを例として述べる。Next, the color stability of the urocanic acid aqueous solution obtained by the present invention will be described using sodium tripolyphosphate and sodium tetrapolyphosphate as examples.
比較例として‘ａ｝ＮａＯＨ／ウロカニン酸＝９／３１
（重量比）の１０％水溶液、｛ｂートリェタノールアミ
ン／ゥロカニン酸＝１１／９の１０％水溶液を、実施例
として‘ａー（ｂーの各々にトリポリリン酸ナトリウム
０．１％添加したもの凶脚及びテトラポリリン酸ナトリ
ウム０．１％添加したもの■血について、種々の上部空
間率〔（容器容量（叫）−試料採取量（叫）／試料採取
量（肌‘）〕を設定したサンプルを調整し、これをキセ
ノンフェードメーターにより、エネルギー量約３．５×
１０７Ｊｏｕｌｅ′で５０ｏｏで３餌時間照射した後の
各水溶液の変色の度合を色差（△Ｅ）として求めた。As a comparative example, 'a}NaOH/urocanic acid = 9/31
A 10% aqueous solution of (weight ratio), a 10% aqueous solution of {b-trietanolamine/urocanic acid = 11/9, and 0.1% sodium tripolyphosphate was added to each of 'a-(b-) as an example. Blood legs and 0.1% sodium tetrapolyphosphate added Samples with various head space ratios [(container capacity (scream) - sample collection amount (scream) / sample collection amount (skin'))] The amount of energy is approximately 3.5× using a xenon fade meter.
The degree of discoloration of each aqueous solution after irradiation with 107 Joule' and 50 oo for 3 feeding hours was determined as a color difference (ΔE).
なお、この条件は、真夏の晴天５日、または真冬の晴天
２０日にほぼ相当する。色差（△Ｅ）は全サンプルの相
対評価をより明白にするため、イオン交換蒸留水を基準
として次式で求めたものである。△Ｅ（Ｌａｂ）＝ノ（
△Ｌ）２十（△ａ）２十（△ｂ）２ただし、△Ｌ、△ａ
、△ｂは２つの色の明度（Ｌ）、色相、彩度（ａ、ｂ）
の差である。Note that this condition approximately corresponds to 5 days of clear weather in midsummer or 20 days of clear weather in midwinter. In order to make the relative evaluation of all samples more clear, the color difference (ΔE) was determined using the following formula using ion-exchange distilled water as a reference. △E(Lab)=ノ(
△L) 20 (△a) 20 (△b) 2 However, △L, △a
, △b is the lightness (L), hue, and saturation (a, b) of the two colors
This is the difference.
△Ｅ値は数値が多い程褐色度が強いことを示す。この測
定には、スガ試験機■のデジタルカラーディフアレンス
コンピューターを使用した。結果を第１図に示す。この
結果から、本発明によって得られるウロカニン酸水溶液
は、褐変度が著しく抑えられ、上部空間量にも殆んど影
響されないことがわかる。次に、上記比較例並びに実施
例における上部空間率を０．４３８とし、他は、上記と
同一条件で、ウロカニン酸のＮａＯＨ水溶液に、トリポ
リリン酸ナトリウム及びテトラポリリン酸ナトリウム並
びにこれと同効物質と考えられる無水リン酸二ナトリウ
ム、亜硫酸ナトリウム十グリセリン（１：１）、チオ硫
酸ナトリウム、ホウ砂、クエン酸ナトリウム、エチレン
ジアミンテトラ酢酸ナトリウムを夫々０．１％添加した
ときの△Ｅの測定結果を参考例として第２図に示す。The higher the ΔE value, the stronger the brownness. For this measurement, a Suga Test Instruments ■ digital color difference computer was used. The results are shown in Figure 1. This result shows that the urocanic acid aqueous solution obtained according to the present invention has a significantly suppressed degree of browning and is hardly affected by the amount of head space. Next, sodium tripolyphosphate, sodium tetrapolyphosphate, and substances with the same effect were added to a NaOH aqueous solution of urocanic acid under the same conditions as above except that the head porosity in the comparative examples and examples was set to 0.438. Refer to the measurement results of △E when 0.1% of each of possible anhydrous disodium phosphate, sodium sulfite deglycerin (1:1), sodium thiosulfate, borax, sodium citrate, and sodium ethylenediaminetetraacetate is added. An example is shown in FIG.
同図より明らかな通り、トリポリリン酸ナトリウム及び
テトラポリリン酸ナトリウムの変色防止効果が極めて優
れていることがわかる。As is clear from the figure, it can be seen that the discoloration prevention effect of sodium tripolyphosphate and sodium tetrapolyphosphate is extremely excellent.
第１図は、実施例及び比較例の上部空間率と変色の度合
（色差△Ｅ）との関係を示すグラフである。
第２図は参考例の０．１％添加時の添加物の種類と変色
の度合い（色差△Ｅ）との関係を示すグラフである。第
１図
第２図FIG. 1 is a graph showing the relationship between the upper porosity and the degree of discoloration (color difference ΔE) in Examples and Comparative Examples. FIG. 2 is a graph showing the relationship between the type of additive and the degree of discoloration (color difference ΔE) when 0.1% of the reference example was added. Figure 1 Figure 2
Claims (1)
はテトラポリリン酸のナトリウム及び／又はカリウム塩
の１種または２種以上を０．０１〜１．０重量％添加す
ることを特徴とするウロカニン酸水溶液の安定化法。1. Stabilization of an aqueous urocanic acid solution characterized by adding 0.01 to 1.0% by weight of one or more sodium and/or potassium salts of tripolyphosphoric acid or tetrapolyphosphoric acid to an alkaline aqueous solution of urocanic acid. Law.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16636379A JPS60352B2 (en) | 1979-12-21 | 1979-12-21 | Stabilization method of uroganic acid aqueous solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16636379A JPS60352B2 (en) | 1979-12-21 | 1979-12-21 | Stabilization method of uroganic acid aqueous solution |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52093096A Division JPS597708B2 (en) | 1977-08-03 | 1977-08-03 | Stabilization method of urocanic acid aqueous solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5663965A JPS5663965A (en) | 1981-05-30 |
| JPS60352B2 true JPS60352B2 (en) | 1985-01-07 |
Family
ID=15830000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16636379A Expired JPS60352B2 (en) | 1979-12-21 | 1979-12-21 | Stabilization method of uroganic acid aqueous solution |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60352B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4823119A (en) * | 1982-12-22 | 1989-04-18 | Tokyo Shibaura Denki Kabushiki Kaisha | Pattern write control circuit |
-
1979
- 1979-12-21 JP JP16636379A patent/JPS60352B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5663965A (en) | 1981-05-30 |
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