JPS6065715A - Production unit for 11c-hydrogen cyanide - Google Patents

Abstract

PURPOSE:To synthesize H<11>CN on line, by sending a <11>Cl2 gas made by a cyclotron and a H2 gas to a furnace containing a reducing catalyst to synthesize a <11>CH4 gas, sending this gas and a NH3 gas to a platinum column. CONSTITUTION:A N2 gas in the bomb 1 is sent to the target box 3 of the small- sized cyclotron 2, it is partially subjected to <14>N(P, alpha)<11>C reaction to give <11>C carbon isotope, which is reacted with O2 to give <11>CO2, and it is sent to the main line 5. While as the flow rate of a H2 gas in the bomb 10 is controlled by the thermal mass flow controller 11, it is sent to the line 5, mixed with <11>CO2, reduced by the furnace 13 containing a reducing catalyst in the electric furnace 12 to synthesize <11>CH4, which is sent through the soda lime column 14 to the Dewar flask 18. A NH3 gas in the bomb 15 is sent through the mass flow controller 16 to the Dewar flask 18, liquefied, it is blended with <11>CH4, sent to the platinum column 26, heated by the electric furnace 25, converted into H<11>CN, passed through the P2O5 column 28 of the purifier 27 and it is purified.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention relates to an apparatus for synthesizing 110 into hydrogen cyanide for medical diagnosis using a radioisotope (RI), that is, a radioactive carbon isotope 11c, synthesized using a small cyclotron, for example. For example, quantitative and dynamic diagnosis of various organs including the brain, stroke, myocardial infarction, etc.
It is used for new diagnoses such as early detection of malignant tumors and investigation of causes of mental illness.

[Conventional technology]

Cyclotron nuclear medicine is 110% 3H, 150, 1l
Short-lived positron-emitting nuclei such as IF are used for medical diagnosis as physiological ton-1 sensors. In the cyclotron target system, these nuclides are generated in simple chemical forms such as inorganic gases, so C can be used as an isotope of an element that forms the skeleton of an organic compound, whether in its original form or modified into a more complex chemical form. Because it is a body, it has the widest applicability and is capable of labeling many important biological substances.

Although some of the synthesis of lIC-labeled compounds is carried out using Ij002 or 11CO produced in the target system as a raw material, most of the synthesis is carried out via C8 compounds as synthetic intermediates. The most widely used C compound is 110-hydrogen cyanide (H"ON).
It is possible to obtain labels for many important biological substances such as sugars, amino acids, and amines.

However, since radionuclides such as ICs have a short half-life of about J minutes, the label synthesis must be carried out quickly, and at the starting stage there is no need for workers to handle large amounts of radioactivity. There is a risk of exposure to radiation, and its synthesis can only be performed by experienced synthesis engineers, making it impossible for routine nuclear medicine diagnosis.

[Object of the present invention]

The purpose of the present invention is to automate the synthesis of IC radionuclides, and to produce HON online, which serves as an intermediate material for synthesizing various labeled compounds.

[Configuration of Example]

An embodiment of the present invention will be described in detail below with reference to the drawings.

As shown in the first diagram, a cylinder filled with N2 gas, which is a raw material for hydrogen 77-chloride containing carbon isotope +1a, is communicated with a target box 3 of a small cyclotron controller, and this target box 3 is connected to I+ Co2 via a box. It communicates with the main pipe of the equipment that synthesizes H”ON using the H”ON as a raw material.

This 11C-hydrogen cyanide (n”cN) production equipment is 11
Each part that reduces 00 to 110 H with N2 and N1 catalyst is divided into +10 H4 and part 7 that synthesizes H"ON with NH3. As shown in the first diagram, in the part B that reduces ICH4, an N2 gas cylinder lO valve is used. V.

Main line j via thermal mass flow controller //
A column 13 containing a reduction catalyst and a soda lime column dander in an electric furnace 12 are connected in series to this main pipe j.

The main pipe as shown in the second diagram! An ammonia gas cylinder/S is connected to the downstream side of pulp v2 via valve v8 + mass flow controller 16, and its main pipe j
is in communication with the lower pressure of a container 19 that stores liquefied NH from a dual bottle cooled with dry ice 17. A liquid level sensor 21 is deeply inserted into a Teflon joint 20 fitted to the upper part of the container, and the pulp V is controlled by a signal from this liquid level sensor 21. The outlet of this container/9 is the valve v
4 + check pal 7" It communicates with the ammonia gas outlet U through the OVI, and also with the vacuum outlet 3 through the pressure control valve vll, and this pulp V is connected to the pressure sensor 2g connected to it. Controlled by signals.

Next, the outlet of this container lq is connected to the electric furnace J via valve v6.
This platinum column 26 is connected to the inlet of the platinum column 26 inside.
Yamaguchi is the purifier 27! The phosphorus oxide column 2g communicates with the lower part of the container 30 of the dual-bottle container through the check valve CV and pulp v7, and the outlet of this container 30 communicates with the outlet port 31 through the valve V.

It is assumed that the piping within this purification device 27 is subjected to acid treatment.

H1 above! The entire ON production equipment is installed in a hot cell for radiation pasting, and the above hull 7"
vI + "l... vs, mass flow controller //, /6, electric furnace /2.23 each step p1
The operation at 1 p, 1...P, is as shown in 5 in the table below.
It is +fl.

Hydrogen cyanide automatic operation status table "U-work ULJl!i"ONσ] Notch (Note-2) When the mass flow controller is at #., it is fully open, and when it is at 'O', it is the set value (Note 3) Electricity When the furnace is marked as ``○'', it is controlled at the set temperature. Fig. 3 is a block diagram of this control device i, where C is a computer and S is its starting push button.

[Operation of the present invention]

Next, the operation of this device will be explained.

First, in step P1, valve v4. v2. V0. Open the mass flow controllers //, /1, and evacuate the inside of the piping. Also 'electric furnace/2. Then, in step P2, open valve V and mass flow -j.
controller//close, and mass flow controller//
Set A to the set value and store the liquefied NH3 in the container'/q.

Next, in step P3, the electric furnace/2.23 is controlled to a predetermined temperature.

Next, in step P4, the cyclotron and bonggu are activated, and in step P, the valve vl is opened (.By this, the crab gas in the cylinder is sent to the target box 3, and a part of it is 14N (P, α ) In the IIC reaction, it becomes carbon isotope i′a, combines with oxygen, and + r co
, and became the main channel by Bongda! sent within. On the other hand, the H2 gas in the cylinder 10 passes through the main pipe with its flow 1 being controlled by the thermal mass flow controller 11. It is mixed with the radiation gas (11(,o, ) from the target box 3, and is sent to the column 13 containing the N1 catalyst installed in the electric furnace 12!θθ~gθO0
It is heated to C to perform the reduction of '+ co,' OH4
Synthesize methane gas. These gases are then sent to soda lime column H, where unreacted 11 (30,) is absorbed by soda lime.

Next, in step P6, valve v* * v6 opens and '1
The cH4 gas is sent to section 7 where the next H''ON is synthesized.

In the part 7 for synthesizing this H"ON, the ammonia gas in the cylinder 15 is sent in advance to the Dua-3Ug via the valve v3 + mass flow controller 16 in step P, and this NH, is mixed with dry ice of -O0c. It is cooled to temperature, liquefied and stored in a Dua-Bottle/g container/9.The reason for liquefying NH is to drag water, which would interfere with the reaction, at a low temperature.

The liquid level of NH3 is monitored by liquid level control using infrared rays, and when a predetermined liquid level is reached, the reaction progresses as expected. II a by passing H,
Mix H, and NH8. This mixed gas is discharged to a constant maximum pressure Pmax ((pressure full + pressure) in step P.

Next, in step P, the pulse] ゛vq + "a 7J- is turned on, and the above mixed gas is sent into the platinum column 26,
The sword mouth is heated to around /θoo Qa by the 4-air furnace 2S, and I
I c n, published JH3-→H"ON+3H, no reaction TeH"ONK is converted. Next, the 0 gas is purified by the purifier 27.
0P, 0. Through column 26', 1 still 7) NH3
is removed. The thus purified H"ON is sent to the container (30) of the dual bottle 29 through the check valve CV2, and collected at dry ice temperature or with an alkaline aqueous solution. Last 11C step P to prevent backflow.
Valve "I I V21 v41 Va 1V,,V
a closes and the synthesis work becomes longer γ [Effects] As described above, according to the present invention, hydrogen cyanide in IC can be automatically synthesized, and the work can be carried out safely without the risk of radiation exposure to workers. It is something.

Therefore, the present invention enables on-line synthesis of H"ON, facilitates the labeled synthesis of important biological substances such as sugars and amino acids, and allows routine nuclear synthesis using these labeled compounds even in general hospitals without specialists. This will enable medical diagnosis and greatly contribute to the spread and development of cyclotron nuclear medicine.

[Brief explanation of drawings]

Figures 1 and 2 show 11002 H2 and N of an embodiment of the present invention.
1 The part that is reduced by a catalyst and IIC! H, and NH,)
3 is a block diagram of the control device, and 3 is a flow diagram. /...Cylinder, Co...Small cyclotron, 3...
・Target box, G...Bonda, j...Main pipe, 6゜7...Device, 10...H2 gas cylinder, 1
2... Electric furnace, /3... N1 column, /l... Soda lime column, Is... Ammonia gas cylinder, 19... Container for liquefying llH8, V,... Pressure control Pulp for use, j... Furnace, U... Shirogane Riki Jim, 2
7... Refining equipment, PI'+ ``2 + '' 3... Steve 〇-1.

Claims (1)

[Claims] N that is a raw material for hydrogen cyanide containing carbon isotope 110
, the cylinder filled with gas is connected to a target box of a small cyclotron, and this target box is connected via a bonder to the main line of a device for synthesizing n1lCH using +1(30,.) as a raw material. , a gas cylinder is communicated, and a column containing a reduction catalyst and a soda lime column in an electric furnace are connected in series to this main pipe.
Next, an ammonia gas cylinder is connected to this main pipe, and it also communicates with a container for storing liquefied NH.The outlet of this container is also connected to a pressure control valve and a platinum column in the furnace. The outlet of the platinum column is connected to the purification equipment. Along with the platinum force H in the furnace
11C-hydrogen cyanide production equipment comprising means for sending to an ON purification equipment.