JPS6116248B2 - - Google Patents

Info

Publication number: JPS6116248B2
Authority: JP; Japan
Prior art keywords: cytochrome; solid; activity; dextran; aqueous solution
Prior art date: 1980-07-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP55097096A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5721315A (en

Inventor

Tsuneo Myake

Sanji Sato

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

OOKURA SEIYAKU KK

Original Assignee

OOKURA SEIYAKU KK

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-15

Filing date

1980-07-15

Publication date

1986-04-28

1980-07-15 Application filed by OOKURA SEIYAKU KK filed Critical OOKURA SEIYAKU KK

1980-07-15 Priority to JP9709680A priority Critical patent/JPS5721315A/ja

1982-02-04 Publication of JPS5721315A publication Critical patent/JPS5721315A/ja

1986-04-28 Publication of JPS6116248B2 publication Critical patent/JPS6116248B2/ja

Status Granted legal-status Critical Current

Links

102100030497 Cytochrome c Human genes 0.000 claims description 64
108010075031 Cytochromes c Proteins 0.000 claims description 64
239000007787 solid Substances 0.000 claims description 31
238000002360 preparation method Methods 0.000 claims description 26
229920002307 Dextran Polymers 0.000 claims description 18
239000007864 aqueous solution Substances 0.000 claims description 18
238000004519 manufacturing process Methods 0.000 claims description 16
238000004108 freeze drying Methods 0.000 claims description 5
238000001694 spray drying Methods 0.000 claims description 3
230000000694 effects Effects 0.000 description 33
239000000203 mixture Substances 0.000 description 10
238000000034 method Methods 0.000 description 9
239000000843 powder Substances 0.000 description 7
239000012265 solid product Substances 0.000 description 7
239000003708 ampul Substances 0.000 description 6
210000004165 myocardium Anatomy 0.000 description 6
239000000523 sample Substances 0.000 description 5
239000003381 stabilizer Substances 0.000 description 5
238000001035 drying Methods 0.000 description 4
239000000047 product Substances 0.000 description 4
GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 4
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
230000002378 acidificating effect Effects 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
239000008103 glucose Substances 0.000 description 3
239000008187 granular material Substances 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
239000008101 lactose Substances 0.000 description 3
229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 3
239000000546 pharmaceutical excipient Substances 0.000 description 3
239000007921 spray Substances 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
108010075027 Cytochromes a Proteins 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
239000008280 blood Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
239000007884 disintegrant Substances 0.000 description 2
238000007922 dissolution test Methods 0.000 description 2
238000009472 formulation Methods 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
238000000691 measurement method Methods 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
230000003647 oxidation Effects 0.000 description 2
238000007254 oxidation reaction Methods 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
239000002994 raw material Substances 0.000 description 2
239000012488 sample solution Substances 0.000 description 2
235000010265 sodium sulphite Nutrition 0.000 description 2
239000000243 solution Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
101710170467 Cytochrome c-a Proteins 0.000 description 1
108010052832 Cytochromes Proteins 0.000 description 1
102000018832 Cytochromes Human genes 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
238000003677 abuse test Methods 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000003729 cation exchange resin Substances 0.000 description 1
230000009087 cell motility Effects 0.000 description 1
229920001429 chelating resin Polymers 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000009849 deactivation Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000007850 degeneration Effects 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
229910001873 dinitrogen Inorganic materials 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000029142 excretion Effects 0.000 description 1
238000009501 film coating Methods 0.000 description 1
239000007888 film coating Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
239000012212 insulator Substances 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000004898 kneading Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
235000013923 monosodium glutamate Nutrition 0.000 description 1
239000004223 monosodium glutamate Substances 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
238000011160 research Methods 0.000 description 1
JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 description 1
239000011343 solid material Substances 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000013112 stability test Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
238000012360 testing method Methods 0.000 description 1

Landscapes

Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

JP9709680A 1980-07-15 1980-07-15 Stable solid preparation of cytochrome c and its preparation Granted JPS5721315A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP9709680A JPS5721315A (en)	1980-07-15	1980-07-15	Stable solid preparation of cytochrome c and its preparation

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP9709680A JPS5721315A (en)	1980-07-15	1980-07-15	Stable solid preparation of cytochrome c and its preparation

Publications (2)

Publication Number	Publication Date
JPS5721315A JPS5721315A (en)	1982-02-04
JPS6116248B2 true JPS6116248B2 (cs)	1986-04-28

Family

ID=14183092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP9709680A Granted JPS5721315A (en)	1980-07-15	1980-07-15	Stable solid preparation of cytochrome c and its preparation

Country Status (1)

Country	Link
JP (1)	JPS5721315A (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6290991B1 (en)	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
US20060174691A1 (en) *	2005-02-07	2006-08-10	David Chazan	Method of controlling degradation of trace gas sensors

1980
- 1980-07-15 JP JP9709680A patent/JPS5721315A/ja active Granted

Also Published As

Publication number	Publication date
JPS5721315A (en)	1982-02-04

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