JPS6122001A - Microcapsule composition - Google Patents

Abstract

PURPOSE:A novel and stable microencapsulated composition composed of microcapsules having both chlordan as an active ingredient and a diluent as core substances and both a polycationic water-soluble nitrogen-containing compound such as gelatin and a hardener as wall substances. CONSTITUTION:A chlordan-containing microencapsulated composition composed of microcapsules containing both 20-85wt% chlordan as an active ingredient and <=50wt% diluent (example; liquid paraffin, vegetable oil, animal oil, etc.) as core substances and both 10-30wt% polycationic water-soluble nitrogen-containing compound (gelatin is preferred) and <=10wt% hardener (example; formaldehyde, glutaraldehyde, glyoxal, etc.) as wall substances. EFFECT:Because of a microcapsule having gelatin as a wall substance, it is destroyed by microorganismas in the soil and the chemicals therein can be completely eluted, and it has prolonged action to reduce the amount thereof used and decreases the strong smell.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a polycationic water-soluble material such as gelatin, which has chlordane as a core material as an active ingredient.

Furthermore, the present invention provides a microcapsule composition comprising the above-mentioned microcapsules, a rounded surfactant and a thickener for preventing agglomeration of the microcapsules, and a conventional microcapsule composition prepared by granulating this with an excipient. Technique 1) U.S. Patent No. 2.800.4.57 discloses that a reed oil-based substance is microencapsulated in a complex coacervation formation method, and the microcapsules are removed by filtration or centrifugal sedimentation. . However, in this method, the microcapsules aggregate with each other, making it difficult to handle and dry.

2) Spray drying is a well-known method that is commonly used to remove substances contained in solutions or dispersions as dry powder, but when using the spray drying method,
Since the wall membrane dries in a short period of time, the membrane becomes porous and easy to break, making it impossible to achieve sufficient encapsulation.

3] In Japanese Patent Publication No. 48-17433, gelatin is hardened in an acidic solution, but hardening in an acidic solution has poor reactivity, and a cationic surfactant is used to prevent microcapsules from forming. However, it remains in the microcapsule body after drying, and is easily converted due to long-term invasiveness.

4) Rapid increase in viscosity 6'Although these surfactants are cationic to prevent agglomeration due to adhesion of microcapsules, these surfactants are unstable and easily dissociate in acidic or alkaline solutions. It also foams strongly. Additionally, anionic surfactants may form water-insoluble salts in hard water, while cationic surfactants have a strong bactericidal effect and may react with cellulose-based disintegrants used when forming granules. and hardens under long-term storage. Furthermore, in order to obtain a good dry powder, a binder and a thickener are added, resulting in good dispersibility in water.

5J When using chlordane as an active ingredient, it is ultimately sprayed as a several-layer aqueous solution, but chlordane has a large specific gravity of +1.631, and even if it is microencapsulated, it will precipitate instantly. In addition, it has the disadvantage that it is bulky in the form of a dry powder, and transportation costs are too high.

6] Currently, chlordane is commercially available as an emulsion, but there are problems with handling and environmental pollution of fish.

Problems to be Solved by the Invention 1) The method of U.S. Pat. No. 2,800.457 has a problem in taking out the microcapsules, but by using the spray drying method in combination, the drawbacks of both methods can be improved.

In order to prevent clogging of the spray nozzle due to adhesion of microcapsule bodies when manufacturing according to the method described in 2J#, a surfactant or the like is added as an anti-agglomeration agent.

3) For materials with a high specific gravity such as L9, such as chlordane, a diluent such as liquid paraffin is added to microcapsule it, and a thickening substance is added and spray-dried to improve stability (uniformity) in the aqueous suspension during spraying. can be kept.

4) By granulating the chlordane microcapsules, it is safe to handle and has economic advantages.

5] Microencapsulation provides long-lasting effects,
It has the advantage of reducing odor and preventing environmental pollution when used at low concentrations.

6) By using non-ionic surfactants, it is more stable and soluble in hard water, rose salts, acids and alkaline solutions than when using anionic and cationic surfactants. There is also little foaming in this condition.

7) Since the microcapsule composition is obtained by adding a water-soluble thickener and a nonionic surfactant is added, the microcapsule composition can be easily dispersed in water. be.

8) The microcapsule composition is stable even if a cellulose-based disintegrant is added during granulation.

Means and action for solving the problems The gist of the present invention - 1) Chlordane and a diluent as active ingredients are used as a core material, and a polycationic water-soluble nitrogen-containing compound and a hardening agent are used as a wall material. An example of microcapsules produced by coacervation.

2) A chlordane-containing composition that is different from the microcapsule composition of item 1.) above, which contains an aggregation inhibitor and a thickener to prevent microcapsules from aggregating with each other. and 3) This relates to a microcapsule composition (granules) obtained by adding an excipient to the dry powder of the microcapsule composition of item 2) above and granulating it.

Chlordane, which is the active ingredient of the chlordane-containing composition of the present invention, has the following structural formula, and is mainly composed of termites,
It is used as a bark beetle exterminator.

The active ingredient in the α α chlordane-containing composition is between 20 and 85%.
(weight f7k), preferably 40 to 80 inches (weight). If it is less than 20%, the desired effect will not be achieved and there will be a problem with effectiveness.

Next, in the most preferred embodiment of obtaining the target composition of the present invention, a generally known coacervation formation method [US Pat. Nos. 2,800,457 and 2,800,458: 1. G.
Bungsnberg do Jong (Leldo-
n1. and H.R., Kruyt I. Utrech.
t l.

'KollOIdReltshriff //vol
50.1930, P 3 '9: Tr
ans, Faradl, Soc Revol 46.
1959゜P 310 'The Theory of
Coac'5rvation //ByC,H,Ra
mford and H, Tompa] is used.

For example, under heating conditions, gelatin as a polycationic water-soluble nitrogen-containing compound, gum arabic as a polyanionic compound, and chlordane were used to form an emulsion containing a diluted solution thereof, and then diluted by adding warm water. Coacervation is formed during post-cooling. Thereafter, add a nonionic surfactant, an anti-aggregation agent, and a curing agent, and adjust the pH to 9 or more under alkaline conditions in this order, or adjust the pH after adding the curing agent\Next, add the nonionic surfactant. 2 to obtain chlordane-containing microcapsules. Next, the microcapsules are collected by decashing, and added to a solution of a water-soluble thickener, followed by injection 9 to obtain a microcapsule composition (for example, granules). The capsule composition is preferably granulated by adding an excipient and using a known granulation means, for example, a cylindrical granulator, to obtain a microcapsule composition (granules).

Diluents used in the chlordane-containing composition of the present invention include liquid paraffin (J containing a light portion, olive oil,
Vegetable oils such as camellia oil, rapeseed oil, castor oil, sesame oil, various animal oils, other hydrogenated oils, neutral oils, petroleum-based organic solvents (such as badruene, xylene, benzene, etc.1), especially liquid paraffin. and a petroleum-based organic solvent (toluene) are preferred.The amount of the diluent added is 50% (weight J or less, preferably 20 to 50% (weight)) based on the total weight of the composition.

The polycationic water-soluble nitrogen-containing compound which is the wall substance of the microcapsule body used in the chlordane-containing composition of the present invention and the polycationic water-soluble nitrogen-containing compound used in the chlordane-containing composition of the present invention; Kunnokuri quality is commonly used.

The sound used in No. 7 is from the perspective of improving sustainability as the objective of the present invention.
) chlordane-containing composition less than 10 (7
30% (weight). Furthermore, polyanionic compounds are used to form microcapsules, and generally have acid groups in their molecules, such as gum arabic, sodium alginate, carrageenan, carpogysimethylcellulose, etc. Various known hardening agents such as formaldehyde, glutaraldehyde, and glyogyzal can be used as the hardening agent to be used in the microcarboxylation. The amount of the curing agent used is 10 cm (by weight) based on the weight of the redan-containing composition from the viewpoint of improving durability. 5 to 100 microcapsules due to coacervation used in the composition containing KuroimaugejiruDan of the present invention.
microns, preferably 10 to 50 microns.゛The anti-aggregation agent in the chlordane-containing composition of the present invention is HLB.
10-20 nonionic surfactant, preferably HL
B 1.5-20 bo-12oxyethylene sorbitan fatty acid ester. From the viewpoint of preventing agglomeration of coacervation particles and water dispersibility of spray-dried granules, the amount should be between 0.25 l/5'5 (weight), preferably 0.25 to 2 l/5'5 (weight), based on the weight of the composition. 11,
It would be acceptable to use a view that exceeds this, but it is technically meaningless.

Examples of such nonionic surfactants include polyoxyethylene tPOEl aliphatic alcohol ether [for example, MULGEN 106 (P
OE lauryl alcohol ether: HLBlo, 51,
EMJJLGEN10 & IPOE lauryl alcohol ether: HLBl2.11, EMUI, GgN220
(POE cetyl alcohol ether; HLB14.2
), EMULGEN40 B 1 pog, tt, '4
Lefurcol Ethe #: HI, B 10.0)
, Br1j 35 (POE+231 lauryl alcohol ether: HLBl6.91, Br5j 781POH
(20) Stearyl alcohol ether: )t L
B 15.3) Brij98 [POEl 20 ) Oleyl alcohol ether: HLBl 15.3), EM
ULGEN340tPOE Steary, II/z-chill:
HLB17.3+, Kyoeisha Yushi Co., Ltd. Nonio Lai) AI,
-11 (POE5 Uriyv:c-chill: )i L B
14.0), noniolyl) AO-20 (POB oleyl ether diHLB15.4J, Nikko Chemicals N)
IKKOLBB-20 (POE behenyl: x, -f#:
HLB171, NIKKOL BL-9EX.

BO-10TX, BC15TX, BH5, Nippon Emulsion Co., Ltd. Emmalex BΔ"10 (POE butyl alcohol ether: HLBl6.9, Emmalex BAI
5 (POE butyl alcohol ether: HLB18
．． 7), Engineering? L/x13Q (POE cetyl alcohol ether: HLBl 6.01, x-qv7x100 (POE-1=-F-# alcohol ether: HLB14.5), Emmalex 5501 POE oleyl alcohol ether: HLB 18.2),
Engineering Vrecx700 (POE 5 U alcohol ether: HLBl6.7), Nonion E-21 manufactured by Nippon Oil & Fats Co., Ltd.
3 (POE oleyl alcohol ether: HLBl3.
6J, Inion E-220 (POvyt-leyl alcohol ether: HLB15.31, Nonion P-225
[poE cetyl alcohol ether: HL B 16
．． 4), NonioyT, NonioyT
-208,5 (POE) lysosyl alcohol ether:
HLBl3.0+, Liponox OC manufactured by Lion Oil Co., Ltd.
8 (POE alkyl ether: HLB15.0), Liponox LCB (POE alkyl ether: I-HLB
l6.21, Liponox O (POE alkyl ether: HLB l4.3), and Adekato manufactured by Asahi Denka Kogyo Co., Ltd.
l SO-120 (POE secondary linear alcohol ethoxylate l, Adekatol SO-
145 (POE secondary linear alcohol ethoxylate)
, Adekatol L O-91P OE primary linear alcohol ethoxylate) 1 , Adekatal L
O-12 (FOE 1st-chain linear alcohol ethoxylate Adskatol L O-15 (P OK primary linear alcohol ethoxylate))], POE alkylaryl ether [eg EMUL manufactured by Kako Atlas Co., Ltd.
GEN810 (POB octyl phenyl ether:
■LB'13.1), EM[JLGEN9111POE
Nonyl phenyl ether: HLBl3.71, EMU
I, GgN930 (POE nonyl phenyl ether diHIIB15.1), EMULGEN9501POE
Nonyl phenyl ether: HLB1&21, Noniolyte PO-9 (FOR octyl phenyl ether: HLBl3.2), Noniosite PA-1 manufactured by Kyoeisha Yushi Co., Ltd.
5 [POE alkyl phenyl ether: HLBl14
．． 3), Emmalex NP-15 manufactured by Nippon Emulsion Co., Ltd.
IPOE furkylphenol ether: HLBl3.2
J.

Emmalex 0P-25 (POE alkylphenol ether: HLB15.8+, Nonion NS manufactured by NOF Corporation)
-215 (FOE nonylphenol ether: HLBl
5. Ol, Nonion NS-220 (POE nonylphenol ether: HLBl6.O), Nonion HS-2
12tPOE octylphenol ether: HLBl4
．． 4+, Nonion H8-22,0 (POE octylphenol ether zs, m>, Lion Oil Co., Ltd. Liponox NCM (POE alkylphenol ether, -te/L-
: HL B 14.51, Liponox NCN (PO
E alkylphenol ether: HLBl 4.8), SyK/7xNCO (for POE flu-phenol ether: HLB 15.0), Non manufactured by Sysr.
1det P-40 (P OE alkylaryl ether), Triton X manufactured by Rohm & Hass
-100 (P OE alkylaryl ether), NIKKOLNP'-10, NP-1 manufactured by Nikko Chemicals
8TX, NP-20゜0F-40, etc.], POE fatty acid knee z f k (e.g. EMANO manufactured by Kako τ Truss Co., Ltd.)
N 1112 (FOE monolaurate: HLBl3.7
1, EMANON4115 (POE monooleate; H
LBl3.4), Myrj45 fPOE (81 stearate: HLB 11.1), Myrj52 (POE
E(40) Stearate: HL Bl 6.91
, M)'rj53 fPOE (501 stearate:
HL B 17.91, Kyoeisha Yushisha Funoniolite S-100 (POE stearate: HL Bl 5
．． 61, Nonioli) T-40 (POE)-ru oil fatty acid: r-sf/lz: HL B 11.5), E
1 bottle Emarex 202 (POE oleate: HL B 15.11, x Max 203 manufactured by Emulsion Co., Ltd.)
(PO'E oleate: HLBl7.6), Knee r V'
7x800 (POE monolaurate: 1 (LB1
5.8), Nonion F-10 (POE monopalmitate: HLB], 5.71, Nonion, s-1
0 (POE monostearate: HLBl51), NO=ONE 5-40 (POE monostearate: HLBl8.
2) MYL-10, MYO-1 manufactured by Nikko Chemicals
0 etc.], PoE sorbitan fatty acid ester [e.g. EMA80L1130CPOE Rubitan monolaurate: HLB16.3 manufactured by Kako Atlas Co., Ltd.], EMASOL3
130 (POgnlupitan monostearate: HLB
l4.9), Tween 2 (l f P O'E
(201 sorbitan' monolaurate: HL B 1
6.7 +, Tween 40 (POE (20) sorbitan monopalmitate: if L B15.61\
Tvrean80TPOE (20) Solpitan monooleate: HLB15. O), Kyoeisha Yushi Co., Ltd. Noniolite TWL-20IPOE (20) Sorbitan monolaurate: HLB16.21 Noni, 1Lite TWS-13 (
POE (13) and tan monostearate: HLB
l 12,5), Dai-Kogyo Seiboku 5QL (, ENT
W20 tPOE Sorbimene Monolaurate: HLBl
6.71.5OLGEN TW80 (POE sorbitan monooleate: HLll) 5.01, Nikko Chemicals NIKKOLTIDL-2020I, IP()E sorbitan olive fatty acid: HLBl 6.5), TL-
10, TO-106, Nippon Emulsion Co., Ltd. Emmalex ET-20+10f POE Norpitan Lauri・
-T: HL Bl 6.6), Nonio y manufactured by NOF Corporation
LT-221tPOE Sorbitan Laurylate:)iL
t316.7), Nonymen 5T-221 (POE sorbitan stearate: HL1314,9], Nonion O
'1' -221 (POE sorbitan oleate: HLB
l5.0), Toho Chemical Industry Co., Ltd.
nT-20(POE sorbitan monolaurate:
HLBl6.7), S*rbenT-40 (POE sorbitan monopalmitate): HLBl5.7), 8orb
enT-80 (POE sorbitan monooleate: HLB
l5.01, etc.], POE sorbitol fatty acid ester [e.g., AL1exl 045 A manufactured by Kajo Atlas Co., Ltd.
, At1ex 1196 (-P OE solpitol oleyl-: HLB 11.4), G-1045 (
POE Norbitolla, Urate: HL Bl 1.
51, G-1441 (POE-enlubitol lanolin-induced 11t: HLB14), Nikko Chemicals Co., Ltd.; NIKK
O'L TSOL-102OL (POE norbitol olive fatty acid ester: HLB16.01 and GL-
1, etc.) POE castor oil-derived oil conductor OE hardened castor oil conductor, such as G-1288 (castor oil [E ethylene adduct: HLBl 6.0) manufactured by Kajo Atlas Co., Ltd., G-1295
(Hydrogenated castor oil oxidized ethylene adduct: I (LB17.5
1. G-1292 + hydrogenated castor oil oxidized ethylene adduct:
HI, n 10.81, NI manufactured by Nikko Chemicals
I (KOL Go-6 (ITX (POE (601 castor oil:) Itl! 14.1) a), POE glycerin fatty acid ester [e.g. NIKK manufactured by Nikko Chemicals Co., Ltd.]
OL TG80215 (Fog glycerin vegetable oil fatty acid ester: HLB14.0), TGSO220 (PO
E-glycerin vegetable oil fatty acid ester: HLB15.5]
, TDGOL-2010I POE diglycerin +1
+-P fatty acid Nisdel: HLBI 2.5!
] and POE conductors [e.g. G-1790, G-1795 manufactured by Kako Atlas Co., Ltd., B manufactured by Nikko Chemicals Co., Ltd.
wA-5, etc.], POE alkylthioether, POE
POE such as propylene glycol monofatty acid ester
A block type nonionic surfactant having a polyoxyprepylene block and a PoE block [for example, P1uronle L12 manufactured by Asahi Denka Kogyo Co., Ltd.
1, L) Carbon number of polyhydric alcohols with 6 or more carbon atoms such as lupitane, innitol, sorbitol, sucrose, etc. and fatty acids of lauric acid, palmitic acid, stearic acid-isostearic acid, and other natural oils and fats such as 22 Examples include polyhydric alcohol type nonionic surfactants that are esters with 12 or more higher fatty acids.

Water-soluble thickeners used in the chlordane-containing composition of the present invention include sodium carboxymeglycellulose, gum arabic, polyvinyl alcohol, dextrin, crystalline cellulose, carboxyvinyl polymer, methylcellulose, polyvinylpyrrolidone, hydroxypropylcellulose, and the like. In particular, crystalline cellulose (RC-type) and carboxyvinyl polymer are preferred.

From the viewpoint of improving binding properties during granule formation and dispersion uniformity during dispersion of granules in water, the above-mentioned thickeners may be used alone or as a mixture of 2ai or more in an amount of 5 to 30% (ii, preferably ii) based on the weight of the chlordane-containing composition. can be used in an amount of 7.5 to 20% (by weight).

At this time, the size of the resulting microcapsules after spray drying is 50 to 300 microns.

The chlordane composition of the present invention can be further granulated with an excipient and used as a microcapsule composition (granules). Examples of excipients include starch, dextrin, crystalline cellulose, hydroxypropyl cell U.-
carbonate, carboxymethylcellulose, calcium carboxymethylcellulose, and inorganic salts such as sodium carbonate, sodium hydrogencarbonate, calcium carbonate, aqueous calcium carbonate, aqueous sodium phosphate, calcium hydrogenphosphate, and sodium sulfate.

The amount of excipient used is the same as the above microcapsule composition 70.
5 to 30% (heavy itJ) to 95chi (heavy fil).

Next, the present invention will be fully explained with reference to examples and examples, but the invention is not limited thereto.

Example 1 320 cc of a 10% (W/) gelatin aqueous solution was prepared by adding a mixture of RIO RUTA 71009 and light liquid paraffin 509.
After emulsifying the emulsion to a size of 5 to 20 μm, the emulsion was heated to 50°C and mixed with
0 yen + w/vl gum arabic aqueous solution 320 ea
1', IQ
Qca was added and diluted.

The resulting diluted solution was ice-cooled to lower the temperature to 5°C to cause coacervation, and 12 g of a nonionic surfactant (Rheodor TW-L120, manufactured by Kako Soap Co., Ltd.) was added, dispersed, and then 25% Add 4 liters of glutaraldehyde aqueous solution, and after 1 hour raise the pH to 9 or above with 20 liters of caustic soda aqueous solution. Raise the temperature to 50°C again and continue stirring for 30 minutes, then return the temperature to room temperature and gelatin wall capsules. A slurry (microcapsules) was obtained.

- after decanting 1% Avicel RC-591
Add 500 cc of NF (Asahi Kasei #!) aqueous solution and 500 cc of 2% dextrin aqueous solution to make a uniform dispersion, and spray dry to obtain a microcapsule composition (50~
300 micron diameter] was obtained.

Low-substituted hydroxypropyl cellulose (ShinM Chemical Exhibition: L-HP) was added to 100 g of this microcapsule composition.
C+ 10. F was added thereto, the mixture was mixed with a 70% ethanol solution, and then granulated to a size of zOIIIIIIφ x 10 pieces using a cylindrical granulation method, and dried to obtain a microcapsule composition (granules j).

Example 2 Spray the chemical evenly over the soil surface, excluding all plants in a 1 inch square soil area, and after the chemical has penetrated into the soil, lay a 1 inch x 6 inch x 6 inch piece of pine wood flat in the center of the treated soil. A test (grand stakes test) was conducted to see whether termites would damage this pine wood.The composition of the microcapsules obtained in Example 1 was The material (granules) was chlordane, the same amount or an amount equivalent to 1/2 of the amount was sown on the soil, and water was sprinkled on top. One year later, all three treatments were 100% effective.

Implementation Ga 3 A certain area of wood was treated with a chemical solution, and the effectiveness against bark beetles was 94% after 30 days and 1 year. 79 obtained in Example 1 using 2% chlordane emulsion as a control product.
The same amount or 1/2 amount of chlordane for granules J was sown on the soil, and water was sprinkled on top of it.The effect after one year was 100% for all three. Admitted.

Example 4 The composition of the chlordane-containing composition of the present invention is as follows.

[A1 Composition Nll N112 Na3D Redan 60
．． OJi' 48.0. li' 48.0.9 Light liquid paraffin --- Dinormano [butyl phthalate -x2. o, p
izo, p gelatin 15.0. li' 1 s
, o+s' 15.0.9 formaldehyde
1.4. li'-glutaraldehyde
4.711 - 4.01 Arabia-r M20
．． OE/270.0. li! 20.99 Chlordane 50. Ol 50. O9 light liquid paraffin 22.5g 25. (), 9 dinormalbutyl phthalate) 2.5. ! i' -Polyoxyethylene hydrogen i and castor oil 0.2510,25
,F Gelatin 15.0g15.0 & Glutaraldehyde 4.7!1 4.79 Gum Arabic
3.5g dextrin 5.0
g1.511 Effects of the invention The effects of the chlordane-containing composition of the invention are as follows.

1) The active ingredient chlordane has been used as an organochlorine insecticide for a long time, but because it is difficult to dissolve in water, it has been confirmed that it remains in the mines, posing an environmental conservation problem. Conventionally, polyvinyl chloride, nylon, and other polymers have been used for microencapsulating insecticides, but until now, there have been no microcapsules using gelatin. Encased gelatin is one centimeter per microorganism in the soil
However, in the former case, the polymer is not destroyed and the drug will diffuse through the porous membrane, so complete elution of the drug cannot be expected.

2) By prolonging the action of chlordane through macro-encapsulation, it is possible to reduce the amount of chlordane used and to reduce the release of strong odors.

3) Sufficiently encapsulated chlordane-containing microcapsules could be obtained by using gelatin microcapsules by the complex coacervation method in combination with a spray drying method.

41 Microencapsulation is useful in terms of safety and handling, but further granulation can be considered as a useful method of distributing the granules on soil and then spraying them with water. This eliminates the risk of scattering and provides economic benefits by reducing the specific volume of the bulky powder.

5J When using an aqueous suspension (7) - Because chlordane has a high specific gravity, it easily settles, so by adding a thickener along with a diluent and spray drying, stability in the aqueous solution can be maintained.

Claims (20)

[Claims] (1) The core material is 20 to 85% (by weight) of the active ingredient of chlordane (same based on the total weight of the composition) and 50% (by weight) or less of a diluent, and 10 to 85% (by weight) of the active ingredient of chlordane, A chlordane-containing microcapsule composition, characterized in that it is a microcapsule body containing 30% (by weight) of a curing agent and 10% (by weight) or less of a curing agent as a wall material. (2) The composition according to item 1 above, wherein the microcapsules are dry microcapsules. (3) The diluent is liquid paraffin, vegetable oil, animal oil,
The composition according to item 1 above, which is a hydrogenated oil, a neutral oil, or a petroleum-based organic solvent. (4) The composition according to item 1 above, wherein the polycationic water-soluble nitrogen-containing compound is gelatin. (5) The composition according to item 1 above, wherein the curing agent is formaldehyde, glutaraldehyde, glyogyzal, or the like. (6) 20 to 85% (by weight) of the active ingredient of chlordane
(based on the total weight of the composition, the same applies hereinafter) and 50% (weight) or less of a diluent as the core material, 10 to 30% (weight) of a polycationic water-soluble nitrogen-containing compound, and 10% (weight) or less of a curing agent. and a microcapsule body containing as a wall substance, 0.25 to 5% (by weight) of an anti-aggregation agent of a nonionic surfactant, and 5 to 30% (by weight) of a water-soluble thickener. A chlordane-containing microcapsule composition. (7) The composition according to item 6, wherein the microcapsule is a dry microcapsule. (8) The diluent is liquid paraffin, vegetable oil, animal oil,
7. The composition according to item 6, which is a hydrogenated oil, a neutral oil, or a petroleum-based organic solvent. (9) The composition according to item 6, wherein the polycationic water-soluble nitrogen-containing compound is gelatin. (10) The composition according to item 6, wherein the curing agent is formaldehyde, glutaraldehyde, or glyogysar. (11) The composition according to item 6, wherein the anti-aggregation agent is a nonionic surfactant with an HLB of 10 to 20, stearic acid, or magnesium stearate. (12) The water-soluble thickener is sodium carboxymethyl cellulose, gum arabic, polyvinyl alcohol,
7. The composition according to item 6, which is dextrin, crystalline cellulose, carboxyvinyl polymer, methylcellulose, polyvinylpyrrolidone, or hydroxypropylcellulose. (13) Microcapsule composition (dry weight basis) 7
A granule containing 0 to 95% (by weight) and 5 to 30% (by weight) of an excipient, wherein 20 to 85% of the above components
(weight) and 50% (weight) or less of the diluent as the core material,
10 to 30% polycationic water-soluble nitrogen-containing compound
(by weight), a hardening agent of 10% (by weight) or less as a wall material, a nonionic surfactant, an anti-aggregation agent of 0.25 to 5% (by weight), and a water-soluble thickener of 5 to 30% (by weight). % (by weight) of a chlordane-containing microcapsule composition. (14) The composition according to item 13, wherein the microcapsule is a dry microcapsule. (15) The composition according to item 13, wherein the diluent is liquid paraffin, animal or vegetable oil, hardened oil, neutral oil, or petroleum-based organic solvent. (16) The composition according to item 13, wherein the polycationic water-soluble nitrogen-containing compound is gelatin. (17) The composition according to item 13, wherein the curing agent is formaldehyde, glutaraldehyde, glyogyzal, or the like. (18) The composition according to item 13, wherein the anti-aggregation agent is a nonionic surfactant with an HLB of 10 to 20, stearic acid, and magnesium stearate. (19) The water-soluble thickener is sodium carboxymethyl cellulose, gum arabic, polyvinyl alcohol,
14. The composition according to item 13, which is dextrin, crystalline cellulose, and carboxyvinyl polymer. (20) Excipients include starch, dextrin, crystalline cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose calcium, sodium carbonate, sodium hydrogen carbonate, calcium carbonate, calcium hydrogen carbonate, sodium hydrogen phosphate, calcium hydrogen phosphate, sulfuric acid 14. The composition according to item 13 above, which is sodium.