JPS61246118A - 抗アレルギ−点鼻薬 - Google Patents

抗アレルギ−点鼻薬

Info

Publication number: JPS61246118A
Authority: JP; Japan
Prior art keywords: drug; solvent; nasal; aqueous solution; allergic
Prior art date: 1985-04-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP8605085A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0586370B2 (fr

Inventor

Masako Motomura

本村　昌子

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-22

Filing date

1985-04-22

Publication date

1986-11-01

1985-04-22 Application filed by Individual filed Critical Individual

1985-04-22 Priority to JP8605085A priority Critical patent/JPS61246118A/ja

1986-11-01 Publication of JPS61246118A publication Critical patent/JPS61246118A/ja

1993-12-10 Publication of JPH0586370B2 publication Critical patent/JPH0586370B2/ja

Status Granted legal-status Critical Current

Links

230000003266 anti-allergic effect Effects 0.000 title claims description 19
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 28
239000003814 drug Substances 0.000 claims abstract description 23
229940079593 drug Drugs 0.000 claims abstract description 22
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 20
239000002904 solvent Substances 0.000 claims abstract description 15
235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 14
229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 14
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims abstract description 10
239000004327 boric acid Substances 0.000 claims abstract description 10
235000010323 ascorbic acid Nutrition 0.000 claims abstract description 9
239000011668 ascorbic acid Substances 0.000 claims abstract description 9
229960005070 ascorbic acid Drugs 0.000 claims abstract description 9
229960000265 cromoglicic acid Drugs 0.000 claims abstract description 7
IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims abstract 3
239000007922 nasal spray Substances 0.000 claims description 20
229940097496 nasal spray Drugs 0.000 claims description 13
206010020751 Hypersensitivity Diseases 0.000 claims description 2
208000026935 allergic disease Diseases 0.000 claims 1
230000007815 allergy Effects 0.000 claims 1
239000007864 aqueous solution Substances 0.000 abstract description 17
239000013566 allergen Substances 0.000 abstract description 10
206010039085 Rhinitis allergic Diseases 0.000 abstract description 9
201000010105 allergic rhinitis Diseases 0.000 abstract description 9
206010039083 rhinitis Diseases 0.000 abstract description 5
239000000243 solution Substances 0.000 abstract description 5
239000007788 liquid Substances 0.000 abstract description 3
238000005406 washing Methods 0.000 abstract description 3
230000003139 buffering effect Effects 0.000 abstract description 2
241000218692 Cryptomeria Species 0.000 abstract 2
241000218645 Cedrus Species 0.000 description 11
239000012153 distilled water Substances 0.000 description 8
230000000694 effects Effects 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
239000003270 steroid hormone Substances 0.000 description 6
230000000172 allergic effect Effects 0.000 description 5
208000010668 atopic eczema Diseases 0.000 description 5
208000024891 symptom Diseases 0.000 description 5
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 4
239000000427 antigen Substances 0.000 description 4
102000036639 antigens Human genes 0.000 description 4
108091007433 antigens Proteins 0.000 description 4
VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 4
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
239000007923 nasal drop Substances 0.000 description 4
229940100662 nasal drops Drugs 0.000 description 4
239000002504 physiological saline solution Substances 0.000 description 4
206010039101 Rhinorrhoea Diseases 0.000 description 3
206010048908 Seasonal allergy Diseases 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
208000010753 nasal discharge Diseases 0.000 description 3
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 3
229960004618 prednisone Drugs 0.000 description 3
108010024636 Glutathione Proteins 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
-1 benzoate ester Chemical class 0.000 description 2
239000000428 dust Substances 0.000 description 2
229960003180 glutathione Drugs 0.000 description 2
230000000147 hypnotic effect Effects 0.000 description 2
238000000034 method Methods 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
230000028327 secretion Effects 0.000 description 2
206010041232 sneezing Diseases 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
241000238876 Acari Species 0.000 description 1
206010065181 Bacterial rhinitis Diseases 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
206010020565 Hyperaemia Diseases 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
206010028735 Nasal congestion Diseases 0.000 description 1
206010052437 Nasal discomfort Diseases 0.000 description 1
208000030880 Nose disease Diseases 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
241001420836 Ophthalmitis Species 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
208000003251 Pruritus Diseases 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
239000002253 acid Substances 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
230000007012 clinical effect Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000002497 edematous effect Effects 0.000 description 1
210000003979 eosinophil Anatomy 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
230000003480 fibrinolytic effect Effects 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
230000002439 hemostatic effect Effects 0.000 description 1
108010073843 histaglobulin Proteins 0.000 description 1
GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
150000002484 inorganic compounds Chemical class 0.000 description 1
229910010272 inorganic material Inorganic materials 0.000 description 1
230000007794 irritation Effects 0.000 description 1
230000007803 itching Effects 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
229940126701 oral medication Drugs 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
208000010403 panophthalmitis Diseases 0.000 description 1
210000004303 peritoneum Anatomy 0.000 description 1
201000004338 pollen allergy Diseases 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
235000004400 serine Nutrition 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000012192 staining solution Substances 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
235000002374 tyrosine Nutrition 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1

Landscapes

Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP8605085A 1985-04-22 1985-04-22 抗アレルギ−点鼻薬 Granted JPS61246118A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP8605085A JPS61246118A (ja)	1985-04-22	1985-04-22	抗アレルギ−点鼻薬

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP8605085A JPS61246118A (ja)	1985-04-22	1985-04-22	抗アレルギ−点鼻薬

Publications (2)

Publication Number	Publication Date
JPS61246118A true JPS61246118A (ja)	1986-11-01
JPH0586370B2 JPH0586370B2 (fr)	1993-12-10

Family

ID=13875853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP8605085A Granted JPS61246118A (ja)	1985-04-22	1985-04-22	抗アレルギ−点鼻薬

Country Status (1)

Country	Link
JP (1)	JPS61246118A (fr)

1985
- 1985-04-22 JP JP8605085A patent/JPS61246118A/ja active Granted

Also Published As

Publication number	Publication date
JPH0586370B2 (fr)	1993-12-10

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