JPS6149246B2 - - Google Patents
Info
- Publication number
- JPS6149246B2 JPS6149246B2 JP13237779A JP13237779A JPS6149246B2 JP S6149246 B2 JPS6149246 B2 JP S6149246B2 JP 13237779 A JP13237779 A JP 13237779A JP 13237779 A JP13237779 A JP 13237779A JP S6149246 B2 JPS6149246 B2 JP S6149246B2
- Authority
- JP
- Japan
- Prior art keywords
- silicate
- water
- magnesium
- aluminate
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000011777 magnesium Substances 0.000 claims description 18
- 229910052749 magnesium Inorganic materials 0.000 claims description 18
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 17
- PGZIKUPSQINGKT-UHFFFAOYSA-N dialuminum;dioxido(oxo)silane Chemical compound [Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O PGZIKUPSQINGKT-UHFFFAOYSA-N 0.000 claims description 15
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 11
- 230000002378 acidificating effect Effects 0.000 claims description 9
- 229910052910 alkali metal silicate Inorganic materials 0.000 claims description 9
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 159000000003 magnesium salts Chemical class 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- -1 alkali metal salt Chemical class 0.000 claims description 5
- 150000004645 aluminates Chemical class 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 238000005406 washing Methods 0.000 description 11
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical group [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 7
- 125000005624 silicic acid group Chemical group 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 229910004298 SiO 2 Inorganic materials 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 150000001339 alkali metal compounds Chemical class 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000004115 Sodium Silicate Substances 0.000 description 4
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 4
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 4
- ANBBXQWFNXMHLD-UHFFFAOYSA-N aluminum;sodium;oxygen(2-) Chemical compound [O-2].[O-2].[Na+].[Al+3] ANBBXQWFNXMHLD-UHFFFAOYSA-N 0.000 description 4
- 229940069428 antacid Drugs 0.000 description 4
- 239000003159 antacid agent Substances 0.000 description 4
- 230000001458 anti-acid effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 229910001629 magnesium chloride Inorganic materials 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 229910001388 sodium aluminate Inorganic materials 0.000 description 4
- 229910052911 sodium silicate Inorganic materials 0.000 description 4
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical group [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 229910000323 aluminium silicate Inorganic materials 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 229910052593 corundum Inorganic materials 0.000 description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 229910001845 yogo sapphire Inorganic materials 0.000 description 2
- BNGXYYYYKUGPPF-UHFFFAOYSA-M (3-methylphenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].CC1=CC=CC(C[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 BNGXYYYYKUGPPF-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004111 Potassium silicate Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000012643 polycondensation polymerization Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 229910052913 potassium silicate Inorganic materials 0.000 description 1
- NNHHDJVEYQHLHG-UHFFFAOYSA-N potassium silicate Chemical compound [K+].[K+].[O-][Si]([O-])=O NNHHDJVEYQHLHG-UHFFFAOYSA-N 0.000 description 1
- 235000019353 potassium silicate Nutrition 0.000 description 1
- KVOIJEARBNBHHP-UHFFFAOYSA-N potassium;oxido(oxo)alumane Chemical compound [K+].[O-][Al]=O KVOIJEARBNBHHP-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 125000005372 silanol group Chemical group 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
Description
【発明の詳細な説明】
本発明は組成中の重合ケイ酸部分が酸不溶性で
ある医療用ケイ酸アルミン酸マグネシウムの新規
な製造法に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel method for producing medical magnesium aluminate silicate in which the polymerized silicic acid moiety in the composition is acid-insoluble.
ケイ酸アルミン酸マグネシウムは持続性のある
酸中和作用を有しており、しかも経時変化のない
優れた制酸剤として消化器疾患の治療に賞用され
ている。従来から知られている組成中のケイ酸部
分が重合したケイ酸アルミン酸マグネシウムに係
る製造法（例えば特開昭48−13509号、特開昭49
−8497号公報参照）はケイ酸成分を重合させるの
に、製造工程で鉱酸類を使用するため、作業者
や、機械、などに対する悪影響があるほか、製造
時に副生する塩類を洗浄除去するために製品量の
400倍という大量の洗浄用水を要する欠点を有し
ており好ましくない。 Magnesium aluminate silicate has a long-lasting acid-neutralizing effect and is an excellent antacid that does not change over time and is used for the treatment of gastrointestinal diseases. Conventionally known manufacturing methods related to magnesium aluminate silicate in which the silicic acid moiety in the composition is polymerized (for example, JP-A-48-13509, JP-A-49
-Refer to Publication No. 8497) uses mineral acids in the manufacturing process to polymerize the silicic acid component, which has a negative impact on workers and machinery, and also to wash and remove salts that are by-produced during manufacturing. of product quantity to
It has the drawback of requiring a 400 times larger amount of water for washing, which is not preferable.
本発明者らは、かかる従来法の欠点を改善する
ための研究を重ねた結果、本発明により鉱酸類を
使用することなく、組成中のケイ酸成分が酸不溶
性である医療用ケイ酸アルミン酸マグネシウムを
得る方法を完成した。 As a result of repeated research to improve the drawbacks of such conventional methods, the present inventors have developed a medical aluminosilicate solution in which the silicic acid component in the composition is acid-insoluble, without using mineral acids. Completed a method to obtain magnesium.
即ち、本発明はケイ酸アルカリと酸性アルミニ
ウム塩とをAl：Si＝1.4〜2.4：10の割合になる量
で使用し、両者を70〜90℃で加熱反応させて得ら
れる重合ケイ酸アルミニウムゲルに水溶性のマグ
ネシウム塩とアルミン酸塩とアルカリ金属塩とを
反応させることからなる組成中のケイ酸部分が酸
不溶性である医療用ケイ酸アルミン酸マグネシウ
ムの製造法を提供するものである。 That is, the present invention uses an alkali silicate and an acidic aluminum salt in a ratio of Al:Si = 1.4 to 2.4:10, and produces a polymerized aluminum silicate gel obtained by heating and reacting the two at 70 to 90°C. The present invention provides a method for producing medical magnesium aluminate silicate in which the silicic acid moiety in the composition is acid-insoluble, which comprises reacting a water-soluble magnesium salt, an aluminate salt, and an alkali metal salt.
本発明を以下に詳細に説明する。 The present invention will be explained in detail below.
本発明方法においては重合ケイ酸アルミニウム
ゲルを得るに際しては、ケイ酸アルカリと酸性ア
ルミニウム塩とを70〜90℃の加熱下で反応させる
が、この反応を行うにあたつてはAl：Si＝1.4〜
2.4：10になるような割合の量でケイ酸アルカリ
と酸性アルミニウム塩とを用い、ケイ酸アルカリ
に対して酸性アルミニウム塩を注加するか、また
は酸性アルミニウム塩に対してケイ酸アルカリを
注加するか、いずれの方法による。本発明方法で
用いるケイ酸アルカリとしては、通常、ケイ酸ナ
トリウム（Na2O／SiO2＝0.25〜0.5）が使用され
るが、ケイ酸カリウムを使用しても良い。酸性ア
ルミニウム塩としては塩化アルミニウム、硝酸ア
ルミニウムあるいは硫酸アルミニウムが用いられ
るが、経済性から考えれば硫酸アルミニウムが好
ましいものである。上記のごとくにして得られた
重合ケイ酸アルミニウムゲルはその構造中にSi原
子がＯ原子を介して繰返し連なる重合ケイ酸部分
とAl原子がＯ原子を介してSi原子と結合した部分
とからなる基本構造を有し、平均的にSi原子10個
に対しAl原子1.4〜2.4個を有するものである。前
述のごときAl対Siの割合でケイ酸アルカリと酸性
アルミニウム塩とを70〜90℃で反応させると、生
成したケイ酸アルミニウムゲルが三次元的に縮重
合し重合度が大きくなり重合ケイ酸部分が酸不溶
性となる。その結果重合ケイ酸アルミニウムゲル
の凝集性が高まり、それが結局後述のケイ酸アル
ミン酸マグネシウムの水洗時のすぐれた効率に寄
与する。 In the method of the present invention, when obtaining a polymerized aluminum silicate gel, an alkali silicate and an acidic aluminum salt are reacted under heating at 70 to 90°C, but when carrying out this reaction, Al:Si=1.4 ~
Using an alkali silicate and an acidic aluminum salt in a ratio of 2.4:10, the acidic aluminum salt is added to the alkali silicate, or the alkali silicate is added to the acidic aluminum salt. or by any method. As the alkali silicate used in the method of the present invention, sodium silicate (Na 2 O/SiO 2 =0.25 to 0.5) is usually used, but potassium silicate may also be used. As the acidic aluminum salt, aluminum chloride, aluminum nitrate, or aluminum sulfate can be used, and aluminum sulfate is preferred from an economic standpoint. The polymerized aluminum silicate gel obtained as described above has a structure consisting of a polymerized silicate part in which Si atoms are repeatedly connected through O atoms, and a part in which Al atoms are bonded to Si atoms through O atoms. It has a basic structure, with an average of 1.4 to 2.4 Al atoms for every 10 Si atoms. When an alkali silicate and an acidic aluminum salt are reacted at 70 to 90°C in the ratio of Al to Si as described above, the resulting aluminum silicate gel undergoes three-dimensional condensation polymerization, increasing the degree of polymerization and forming a polymerized silicate portion. becomes acid insoluble. As a result, the cohesiveness of the polymerized aluminum silicate gel increases, which ultimately contributes to the excellent efficiency of washing magnesium aluminate silicate with water, which will be described later.
本発明方法により得られるケイ酸アルミン酸マ
グネシウムの特徴的利点である。 These are the characteristic advantages of magnesium aluminate silicate obtained by the method of the invention.
(1) 組成中のケイ酸部分が酸不溶性である
(2) 水洗時の洗浄効率においてすぐれているは、
前述のケイ酸アルカリと酸性アルミニウム塩に
おける
Al対Siの特定の割合
70〜90℃の反応温度
の条件の組合せによつてのみ得られるものであ
る。(1) The silicic acid part in the composition is acid-insoluble. (2) It has excellent cleaning efficiency when washed with water.
The specific ratio of Al to Si in the alkali silicate and acidic aluminum salt described above can only be obtained by a combination of conditions such as a reaction temperature of 70 to 90°C.
この様にして得られる重合ケイ酸アルミニウム
ゲルの構造には多くの活性シラノール基が存在す
るので、次の工程に好都合な反応部位を与える。
即ち、前述のようにして得られた活性な重合ケイ
酸アルミニウムゲルに対し、水溶性のマグネシウ
ム塩とアルミン酸塩とアルカリ金属化合物とを反
応させると、本発明の目的化合物であるケイ酸ア
ルミン酸マグネシウムを得ることができる。この
工程においては、PHが8.5〜11.0になるように重
合ケイ酸アルミニウムゲルに予め水溶性のマグネ
シウム塩を加え、次いでアルミン酸塩とアルカリ
金属化合物とを順に加えるか、または水溶性のマ
グネシウム塩と、アルミン酸塩とアルカリ金属化
合物とを同時に注加するかいずれかの方法を行
う。ここで用いられる水溶性のマグネシウム塩は
塩化マグネシウム、硝酸マグネシウムあるいは硫
酸マグネシウムから選ばれる。またアルミン酸塩
としてはアルミン酸ナトリウム、アルミン酸カリ
ウムが用いられ、アルカリ金属化合物としては、
ナトリウムまたはカリウムの水酸化物、炭酸水素
塩、炭酸塩の１種または２種以上の混合物が選択
して使用される。また、反応温度は常温〜60℃の
間で行なうのが好ましい。 The structure of the polymerized aluminum silicate gel thus obtained has many active silanol groups, thus providing convenient reaction sites for the next step.
That is, when the active polymerized aluminum silicate gel obtained as described above is reacted with a water-soluble magnesium salt, an aluminate salt, and an alkali metal compound, aluminosilicate, which is the target compound of the present invention, is produced. You can get magnesium. In this step, a water-soluble magnesium salt is added in advance to the polymerized aluminum silicate gel so that the pH is 8.5 to 11.0, and then an aluminate and an alkali metal compound are added in order, or a water-soluble magnesium salt and , or by simultaneously adding an aluminate and an alkali metal compound. The water-soluble magnesium salt used here is selected from magnesium chloride, magnesium nitrate or magnesium sulfate. In addition, sodium aluminate and potassium aluminate are used as aluminates, and as alkali metal compounds,
One or a mixture of two or more of sodium or potassium hydroxide, hydrogen carbonate, and carbonate may be selected and used. Further, the reaction temperature is preferably between room temperature and 60°C.
本発明の方法の第２工程において、適度に凝集
した重合ケイ酸アルミニウムゲルに水溶性のマグ
ネシウム塩とアルミン酸塩とアルカリ金属化合物
とを反応させるとき、凝集した大きな粒子径のケ
イ酸アルミン酸マグネシウムが生成する。このゲ
ルは粒子径が大きいため、沈降速度も速く従つ
て、洗浄効率や過性が良好となる。このケイ酸
アルミン酸マグネシウムゲルの反応生成液中に溶
解している副生塩を除去するため、流下過式洗
浄槽（フイルターウオツシヤー）を用いて、５
W/V%の濃度で洗浄すれば洗浄に要する日数は
１〜２日であり、必要な洗浄用水の使用量は製品
重量に対して100〜150倍であるのに対して、従来
法で得られるケイ酸アルミン酸マグネシウムゲル
の洗浄処理においては、数日〜十数日を要する
上、製品量の400倍もの洗浄用水を必要とする。
また、通水型フイルタープレスにて過洗浄する
場合においても１回のフイードあたりの過洗浄
時間及び必要な洗浄用水量は本発明の方法で得ら
れたものはそれぞれ１〜２時間、100〜150倍であ
るのに対して、、従来の方法で得られたものでは
それぞれ６〜８時間、400倍であつた。この様に
本発明の方法において生成したケイ酸アルミン酸
マグネシウムゲルを洗浄により精製する場合、従
来法に比較して洗浄時間で1/5〜1/8、洗浄用水量
で1/3〜1/4というすぐれた洗浄効率が得られ、製
造コストの著しい低減をもたらす。 In the second step of the method of the present invention, when a moderately aggregated polymerized aluminum silicate gel is reacted with a water-soluble magnesium salt, an aluminate, and an alkali metal compound, the aggregated magnesium aluminate silicate gel has a large particle size. is generated. Since this gel has a large particle size, the sedimentation rate is fast, and the washing efficiency and permeability are good. In order to remove by-product salts dissolved in the reaction product solution of this magnesium aluminate silicate gel, a filter washer was used to remove the by-product salts.
If cleaning is performed at a concentration of W/V%, the number of days required for cleaning is 1 to 2 days, and the amount of cleaning water required is 100 to 150 times the product weight, whereas with conventional methods, The cleaning treatment of magnesium aluminate silicate gel takes several days to more than ten days and requires 400 times the amount of cleaning water as the amount of product.
In addition, even when over-washing is performed using a water-flow type filter press, the over-washing time and amount of water required for one feed are 1 to 2 hours and 100 to 150 hours, respectively, for those obtained by the method of the present invention. In contrast, those obtained by conventional methods took 6 to 8 hours and 400 times longer. As described above, when the magnesium aluminate silicate gel produced by the method of the present invention is purified by washing, the washing time is 1/5 to 1/8 and the amount of washing water is 1/3 to 1/3 compared to the conventional method. An excellent cleaning efficiency of 4 is obtained, resulting in a significant reduction in manufacturing costs.
本発明方法によつて得られるケイ酸アルミン酸
マグネシウムの組成中に含まれる重合ケイ酸部分
は0.5規定塩酸水溶液と微温浴中で数時間振盪し
ても溶解しない。このような性質の重合ケイ酸部
分を持つケイ酸アルミン酸マグネシウムを内服し
た場合、重合ケイ酸部分は胃中でも不溶性のゲル
を保ち胃壁保護作用を示し医療上好ましい結果を
もたらす。 The polymerized silicic acid moiety contained in the composition of the magnesium aluminate silicate obtained by the method of the present invention does not dissolve even when shaken with a 0.5N aqueous hydrochloric acid solution in a lukewarm bath for several hours. When magnesium aluminate silicate having such a polymerized silicic acid moiety is taken internally, the polymerized silicic acid moiety maintains an insoluble gel even in the stomach, exhibits a gastric wall protective effect, and brings about medically favorable results.
以下に本発明の実施例を示す。 Examples of the present invention are shown below.
実施例 １
417KgのJIS3号けい酸ソーダ（Na2O／SiO2モル
比0.32、SiO2含有量27.0％）を水1200に溶解し
温度85℃に加温して、激しく撹拌しながら140Kg
の硫酸アルミニウム（Al2O3含量、17.3％）水溶
液300を徐々に添加する。さらに60分間、撹拌
し、30℃まで冷却した後に食品添加用塩化マグネ
シウム（MgO含量19.8％）202Kgを水1150に溶
解した溶液を加え、次いでアルミン酸ナトリウム
（Na2O／Al2O3モル比1.5、Al2O3含量22％）349Kg
を含む水溶液1200、水酸化ナトリウム4.8Kgを
含む水溶液100を順次加えて60分間撹拌を行な
う。（最終PH11.0）反応生成液をフイルターウオ
ツシヤー（有効量10000）に投入し、副生塩を
除去した後（洗浄用水使用量42m3）スラリーを圧
過機を用いて固液分離し、得られたケーキを
100℃以下の温度で乾燥し、粉末状となし、ケイ
酸アルミン酸マグネシウム393Kgを得た。Example 1 417 kg of JIS No. 3 sodium silicate (Na 2 O / SiO 2 molar ratio 0.32, SiO 2 content 27.0%) was dissolved in 1,200 ml of water, heated to 85°C, and 140 kg was dissolved with vigorous stirring.
Gradually add 300 g of an aqueous solution of aluminum sulfate ( Al2O3 content , 17.3%). After stirring for an additional 60 minutes and cooling to 30°C, a solution of 202 kg of food additive magnesium chloride (MgO content 19.8%) dissolved in 1150 kg of water was added, followed by sodium aluminate (Na 2 O / Al 2 O 3 molar ratio). 1.5, Al2O3 content 22%) 349Kg
1,200 kg of an aqueous solution containing 1,200 kg of sodium hydroxide and 100 kg of an aqueous solution containing 4.8 kg of sodium hydroxide were added sequentially and stirred for 60 minutes. (Final pH 11.0) The reaction product liquid was put into a filter washer (effective amount: 10,000) to remove by-product salts (washing water amount used: 42 m 3 ), and the slurry was separated into solid and liquid using a pressure filter. , the resulting cake
It was dried at a temperature of 100°C or lower to form a powder, yielding 393 kg of magnesium aluminate silicate.
この乾燥品の品質は次のとおりであつた。 The quality of this dried product was as follows.
Al2O3 27.2％ 制酸度 210ml/ｇ
MgO 10.8％ フツクス持続時間 63分
SiO2 31.6％
水 分 9.8％
実施例 ２
26.2Kgの塩化アルミニウム（Al2O3含量21.2％
を水110に溶解し、温度75℃に加温して、撹拌
しながらJIS3号けい酸ソーダ115Kgを水60に溶
解した液を徐々に加える。その後さらに１時間撹
拌をつづける。50℃に冷却した後、食品添加用塩
化マグネシウム55.6Kgを含む水溶液100とアル
ミン酸ナトリウム（Na2O／Al2O3＝1.5、Al2O3含
量22％）92Kg及び水酸化カリウム1.5Kgを含む水
溶液100を同時に滴下させ反応する。その後更
に１時間撹拌する（最終PH10.8）。以下実施例１
と同様の操作によりケイ酸アルミン酸マグネシウ
ム41.8Kgを得た。洗浄水量は4.8m3であつた。Al 2 O 3 27.2% Antacid level 210ml/g MgO 10.8% Fuss duration 63 minutes SiO 2 31.6% Moisture 9.8% Example 2 26.2Kg of aluminum chloride (Al 2 O 3 content 21.2%
Dissolve in 110 kg of water, heat to 75°C, and gradually add a solution of 115 kg of JIS No. 3 sodium silicate dissolved in 60 kg of water while stirring. Stirring was then continued for an additional hour. After cooling to 50°C, 100 kg of an aqueous solution containing 55.6 kg of food additive magnesium chloride, 92 kg of sodium aluminate (Na 2 O / Al 2 O 3 = 1.5, Al 2 O 3 content 22%) and 1.5 kg of potassium hydroxide were added. An aqueous solution containing 100 ml of water was simultaneously added dropwise to react. Then stir for an additional hour (final pH 10.8). Example 1 below
41.8 kg of magnesium aluminate silicate was obtained by the same operation as above. The amount of washing water was 4.8m3 .
得られた乾燥製品の品質は次のとおりであつ
た。 The quality of the obtained dried product was as follows.
Al2O3 28.3％ 制酸度 219ml/ｇ
MgO 11.3％ フツクス持続時間 66分
SiO2 32.5％
水 分 10.6％
実施例 ３
JIS3号のケイ酸ソーダ56.4Kgを水300に溶解
し、温度80℃に加熱し、硫酸アルミニウム
（Al2O3含量17.3％）14.2Kgを溶解した水溶液50
を撹拌しながら加え、さらに撹拌を１時間続け
る。30℃に冷却した後食品添加用塩化マグネシウ
ム109Kgを含む水溶液300、アルミン酸ナトリウ
ム（Na2O／Al2O3＝1.7、Al2O3含量19％）131Kg
を含む水溶液280、重槽11.8Kgを含む液20を
順次加え、さらに１時間撹拌する。（最終PH9.8）
通水型フイルタープレスを用いて、過後、１時
間通水し、洗浄を終了する。通水量は12m3であつ
た。得られたケーキを入熱温度220〜230℃で噴露
乾燥し、ケイ酸アルミン酸マグネシウム98Kgを得
た。Al 2 O 3 28.3% Antacid level 219ml/g MgO 11.3% Fuss duration 66 minutes SiO 2 32.5% Water 10.6% Example 3 56.4 kg of JIS No. 3 sodium silicate was dissolved in 300 ml of water and heated to 80°C. and an aqueous solution containing 14.2 kg of aluminum sulfate (Al 2 O 3 content 17.3%) 50
Add with stirring and continue stirring for an additional hour. After cooling to 30℃, 300 kg of aqueous solution containing 109 kg of magnesium chloride for food addition, 131 kg of sodium aluminate (Na 2 O / Al 2 O 3 = 1.7, Al 2 O 3 content 19%)
280 of an aqueous solution containing 11.8 kg of a heavy tank and 20 of a solution containing 11.8 kg of a heavy tank were added in sequence, and the mixture was further stirred for 1 hour. (Final PH9.8)
Using a water filter press, water is passed for 1 hour to complete the washing. The water flow rate was 12m3 . The resulting cake was spray-dried at a heat input temperature of 220 to 230°C to obtain 98 kg of magnesium aluminate silicate.
この乾燥製品の品質は次のとおりであつた。 The quality of this dried product was as follows.
Al2O3 27.3％ 制酸度 251ml MgO 21.4％ フツクス持続時間 90分 SiO2 16.0％ 水 分 11.2％Al 2 O 3 27.3% Antacid level 251ml MgO 21.4% Fuss duration 90 minutes SiO 2 16.0% Water 11.2%
Claims (1)
Al：Si＝1.4〜2.4：10の割合になる量で使用し、
両者を70〜90℃で加熱反応させて得られる重合ケ
イ酸アルミニウムゲルに水溶性のマグネシウム塩
とアルミン酸塩とアルカリ金属塩とを反応させる
ことからなる組成中の重合ケイ酸部分が酸不溶性
である医療用ケイ酸アルミン酸マグネシウムの製
造法。1 Alkali silicate and acidic aluminum salt
Use in an amount with a ratio of Al:Si = 1.4 to 2.4:10,
The polymerized aluminum silicate gel in the composition is made by reacting a water-soluble magnesium salt, an aluminate, and an alkali metal salt with a polymerized aluminum silicate gel obtained by heating the two to react at 70 to 90°C. A method for producing medical magnesium aluminate silicate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13237779A JPS5659617A (en) | 1979-10-16 | 1979-10-16 | Manufacture of magnesium silicoaluminate for medical treatment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13237779A JPS5659617A (en) | 1979-10-16 | 1979-10-16 | Manufacture of magnesium silicoaluminate for medical treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5659617A JPS5659617A (en) | 1981-05-23 |
| JPS6149246B2 true JPS6149246B2 (en) | 1986-10-28 |
Family
ID=15079947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13237779A Granted JPS5659617A (en) | 1979-10-16 | 1979-10-16 | Manufacture of magnesium silicoaluminate for medical treatment |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5659617A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107902662A (en) * | 2017-10-24 | 2018-04-13 | 安徽国创非金属矿业科技有限公司 | A kind of preparation method of high dispersibility high viscosity aluminium magnesium silicate inorganic gel |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59203723A (en) * | 1983-05-04 | 1984-11-17 | Nippon Chem Ind Co Ltd:The | Modified aluminosilicate and its manufacture |
-
1979
- 1979-10-16 JP JP13237779A patent/JPS5659617A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107902662A (en) * | 2017-10-24 | 2018-04-13 | 安徽国创非金属矿业科技有限公司 | A kind of preparation method of high dispersibility high viscosity aluminium magnesium silicate inorganic gel |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5659617A (en) | 1981-05-23 |
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