JPS61501428A - インタ−ロイキン−２を酵母内で発現するベクタ−、形質転換された酵母及びインタ−ロイキン−２の製造法 - Google Patents

インタ−ロイキン−２を酵母内で発現するベクタ−、形質転換された酵母及びインタ−ロイキン−２の製造法

Info

Publication number
JPS61501428A
JPS61501428A JP60500770A JP50077085A JPS61501428A JP S61501428 A JPS61501428 A JP S61501428A JP 60500770 A JP60500770 A JP 60500770A JP 50077085 A JP50077085 A JP 50077085A JP S61501428 A JPS61501428 A JP S61501428A
Authority
JP
Japan
Prior art keywords
yeast
vector
plasmid
replication
promoter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP60500770A
Other languages
English (en)
Japanese (ja)
Inventor
ルモアン　イブ
サンダミーヤ　ポール
ロワソン　ジエラール
エグル　ミツシエル
ルコツク　ジヤン‐ピエール
Original Assignee
トランスジ−ン　ソシエテ　アノニム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by トランスジ−ン　ソシエテ　アノニム filed Critical トランスジ−ン　ソシエテ　アノニム
Publication of JPS61501428A publication Critical patent/JPS61501428A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP60500770A 1984-02-16 1985-02-15 インタ−ロイキン−２を酵母内で発現するベクタ−、形質転換された酵母及びインタ−ロイキン−２の製造法 Pending JPS61501428A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8402350A FR2559782B1 (fr) 1984-02-16 1984-02-16 Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2
FR8402350 1984-02-16

Publications (1)

Publication Number Publication Date
JPS61501428A true JPS61501428A (ja) 1986-07-17

Family

ID=9301097

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60500770A Pending JPS61501428A (ja) 1984-02-16 1985-02-15 インタ−ロイキン−２を酵母内で発現するベクタ−、形質転換された酵母及びインタ−ロイキン−２の製造法

Country Status (5)

Country Link
EP (1) EP0152358A1 (da)
JP (1) JPS61501428A (da)
DK (1) DK472285D0 (da)
FR (1) FR2559782B1 (da)
WO (1) WO1985003723A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0162898A4 (en) * 1983-11-14 1987-07-23 Chiron Corp INTERLEUKIN-2 GENERATION USING CLONED GENES FOR INTERLEUKIN-2 AND YEAR ALPHA FACTOR.
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
DE3537461A1 (de) * 1985-10-22 1987-04-23 Hoechst Ag Derivat des interleukin-2, seine herstellung und verwendung
JPS62185098A (ja) * 1986-02-10 1987-08-13 Otsuka Pharmaceut Co Ltd インタ−ロイキン−２活性を有するポリペプチド
US4992367A (en) * 1986-05-12 1991-02-12 Hoffmann-La Roche Inc. Enhanced expression of human interleukin-2 in mammalian cells
IL89989A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human interleukin-2 in methylotrophic yeasts
WO1991005051A1 (fr) * 1989-09-28 1991-04-18 Leningradsky Gosudarstvenny Universitet Procede d'obtention de polypeptides d'interleukine-2 humaine dans des cellules de levure
RU2230781C1 (ru) * 2002-12-27 2004-06-20 Общество с ограниченной ответственностью "Биотех" Штамм дрожжей saccharomyces cerevisiae 1-60-д578 (msil), - продуцент рекомбинантного интерлейкина-2 человека и способ его получения
RU2304586C1 (ru) * 2006-03-27 2007-08-20 Михаил Николаевич Смирнов Препарат интерлейкина-2 и способ его получения
RU2322452C2 (ru) * 2006-03-27 2008-04-20 Михаил Николаевич Смирнов Иммуномодулирующая композиция

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2469454A2 (fr) * 1979-11-13 1981-05-22 Anvar Nouveaux plasmides hybrides et micro-organismes les contenant
US4615974A (en) * 1981-08-25 1986-10-07 Celltech Limited Yeast expression vectors
DE3377363D1 (en) * 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells

Also Published As

Publication number Publication date
FR2559782B1 (fr) 1986-07-18
WO1985003723A1 (fr) 1985-08-29
FR2559782A1 (fr) 1985-08-23
DK472285A (da) 1985-10-15
EP0152358A1 (fr) 1985-08-21
DK472285D0 (da) 1985-10-15

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