JPS61501866A - 分析用多層要素 - Google Patents

分析用多層要素

Info

Publication number: JPS61501866A
Authority: JP; Japan
Prior art keywords: layer; reagent; detectable species; registration; antibody
Prior art date: 1984-05-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP59502271A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0449911B2 (fr

Inventor

バーク，カール　メインズ

Original Assignee

ポラロイド　コ−ポレ−シヨン

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-29

Filing date

1984-05-29

Publication date

1986-08-28

1984-05-29 Application filed by ポラロイド　コ−ポレ−シヨン filed Critical ポラロイド　コ−ポレ−シヨン

1984-05-29 Priority claimed from PCT/US1984/000835 external-priority patent/WO1985005686A1/fr

1986-08-28 Publication of JPS61501866A publication Critical patent/JPS61501866A/ja

1992-08-12 Publication of JPH0449911B2 publication Critical patent/JPH0449911B2/ja

Status Granted legal-status Critical Current

Links

238000004458 analytical method Methods 0.000 title claims description 15
239000000427 antigen Substances 0.000 claims description 42
102000036639 antigens Human genes 0.000 claims description 41
108091007433 antigens Proteins 0.000 claims description 41
239000003153 chemical reaction reagent Substances 0.000 claims description 32
238000006243 chemical reaction Methods 0.000 claims description 26
239000012491 analyte Substances 0.000 claims description 21
229920000936 Agarose Polymers 0.000 claims description 20
239000007788 liquid Substances 0.000 claims description 20
239000000463 material Substances 0.000 claims description 20
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 13
238000009792 diffusion process Methods 0.000 claims description 12
230000005855 radiation Effects 0.000 claims description 11
239000000758 substrate Substances 0.000 claims description 8
238000000926 separation method Methods 0.000 claims description 6
239000004408 titanium dioxide Substances 0.000 claims description 6
239000004793 Polystyrene Substances 0.000 claims description 5
229920002223 polystyrene Polymers 0.000 claims description 5
230000003100 immobilizing effect Effects 0.000 claims description 3
239000004744 fabric Substances 0.000 claims description 2
239000004816 latex Substances 0.000 claims 1
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230000014759 maintenance of location Effects 0.000 claims 1
239000000941 radioactive substance Substances 0.000 claims 1
241000894007 species Species 0.000 description 32
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238000000034 method Methods 0.000 description 23
239000000523 sample Substances 0.000 description 22
238000012360 testing method Methods 0.000 description 14
239000000243 solution Substances 0.000 description 12
238000001514 detection method Methods 0.000 description 11
229920000642 polymer Polymers 0.000 description 10
108060003951 Immunoglobulin Proteins 0.000 description 9
102000018358 immunoglobulin Human genes 0.000 description 9
238000001114 immunoprecipitation Methods 0.000 description 7
239000000203 mixture Substances 0.000 description 7
BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 6
108010010803 Gelatin Proteins 0.000 description 6
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239000008273 gelatin Substances 0.000 description 6
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239000002202 Polyethylene glycol Substances 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
238000006073 displacement reaction Methods 0.000 description 3
239000003446 ligand Substances 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
239000002953 phosphate buffered saline Substances 0.000 description 3
229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
239000001267 polyvinylpyrrolidone Substances 0.000 description 3
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
239000010409 thin film Substances 0.000 description 3
GBBVHDGKDQAEOT-UHFFFAOYSA-N 1,7-dioxaspiro[5.5]undecane Chemical compound O1CCCCC11OCCCC1 GBBVHDGKDQAEOT-UHFFFAOYSA-N 0.000 description 2
102000009027 Albumins Human genes 0.000 description 2
108010088751 Albumins Proteins 0.000 description 2
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
235000019944 Olestra Nutrition 0.000 description 2
102000007562 Serum Albumin Human genes 0.000 description 2
108010071390 Serum Albumin Proteins 0.000 description 2
239000013060 biological fluid Substances 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
239000007795 chemical reaction product Substances 0.000 description 2
238000002967 competitive immunoassay Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
239000000835 fiber Substances 0.000 description 2
239000010408 film Substances 0.000 description 2
239000012847 fine chemical Substances 0.000 description 2
239000012530 fluid Substances 0.000 description 2
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
238000001917 fluorescence detection Methods 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
229940072221 immunoglobulins Drugs 0.000 description 2
238000002372 labelling Methods 0.000 description 2
230000000670 limiting effect Effects 0.000 description 2
-1 p-nonylphenoxy Chemical group 0.000 description 2
239000002245 particle Substances 0.000 description 2
238000011002 quantification Methods 0.000 description 2
239000000700 radioactive tracer Substances 0.000 description 2
230000001568 sexual effect Effects 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000004381 surface treatment Methods 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
239000010936 titanium Substances 0.000 description 2
230000007704 transition Effects 0.000 description 2
229920002554 vinyl polymer Polymers 0.000 description 2
FEMVWXUMIWVIQK-UHFFFAOYSA-N 4-ethenylpyridine Chemical compound C(=C)C1=CC=NC=C1.C(=C)C1=CC=NC=C1 FEMVWXUMIWVIQK-UHFFFAOYSA-N 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
208000023514 Barrett esophagus Diseases 0.000 description 1
241000283707 Capra Species 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
229920001917 Ficoll Polymers 0.000 description 1
102000006395 Globulins Human genes 0.000 description 1
108010044091 Globulins Proteins 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
241001494479 Pecora Species 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
239000002998 adhesive polymer Substances 0.000 description 1
239000002390 adhesive tape Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000010425 asbestos Substances 0.000 description 1
KXHPPCXNWTUNSB-UHFFFAOYSA-M benzyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC1=CC=CC=C1 KXHPPCXNWTUNSB-UHFFFAOYSA-M 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
OIPMQULDKWSNGX-UHFFFAOYSA-N bis[[ethoxy(oxo)phosphaniumyl]oxy]alumanyloxy-ethoxy-oxophosphanium Chemical compound [Al+3].CCO[P+]([O-])=O.CCO[P+]([O-])=O.CCO[P+]([O-])=O OIPMQULDKWSNGX-UHFFFAOYSA-N 0.000 description 1
238000005885 boration reaction Methods 0.000 description 1
239000007975 buffered saline Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
230000008859 change Effects 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000002860 competitive effect Effects 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
239000002131 composite material Substances 0.000 description 1
239000013068 control sample Substances 0.000 description 1
239000010949 copper Substances 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
DTVMXQFQTCJMOR-UHFFFAOYSA-N dioctyl propanedioate Chemical compound CCCCCCCCOC(=O)CC(=O)OCCCCCCCC DTVMXQFQTCJMOR-UHFFFAOYSA-N 0.000 description 1
NJLLQSBAHIKGKF-UHFFFAOYSA-N dipotassium dioxido(oxo)titanium Chemical compound [K+].[K+].[O-][Ti]([O-])=O NJLLQSBAHIKGKF-UHFFFAOYSA-N 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
239000002657 fibrous material Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000003292 glue Substances 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
230000036541 health Effects 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
150000002540 isothiocyanates Chemical class 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
239000000123 paper Substances 0.000 description 1
239000011236 particulate material Substances 0.000 description 1
230000035699 permeability Effects 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000139 polyethylene terephthalate Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000002028 premature Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000004445 quantitative analysis Methods 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
230000003307 reticuloendothelial effect Effects 0.000 description 1
229910052895 riebeckite Inorganic materials 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
238000002791 soaking Methods 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
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239000004575 stone Substances 0.000 description 1
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238000012546 transfer Methods 0.000 description 1
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Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Physics & Mathematics (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Sampling And Sample Adjustment (AREA)
Analysing Materials By The Use Of Radiation (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Investigating Or Analysing Biological Materials (AREA)

JP59502271A 1984-05-29 1984-05-29 分析用多層要素 Granted JPS61501866A (ja)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1984/000835 WO1985005686A1 (fr)	1982-12-29	1984-05-29	Element multicouche pour analyse

Publications (2)

Publication Number	Publication Date
JPS61501866A true JPS61501866A (ja)	1986-08-28
JPH0449911B2 JPH0449911B2 (fr)	1992-08-12

Family

ID=22182152

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP59502271A Granted JPS61501866A (ja)	1984-05-29	1984-05-29	分析用多層要素

Country Status (4)

Country	Link
JP (1)	JPS61501866A (fr)
AT (1)	ATE54756T1 (fr)
AU (1)	AU576771B2 (fr)
DE (1)	DE3482773D1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1261743A (fr) *	1984-07-23	1989-09-26	Shai Inbar	Produit pour les essais de diagnostic biologiques et procede utilisant des fragments fab marques

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS53131089A (en) *	1977-01-14	1978-11-15	Eastman Kodak Co	Element for analysis of liquid
JPS5767860A (en) *	1980-10-15	1982-04-24	Fuji Photo Film Co Ltd	Material for multilayer analysis
JPS57200862A (en) *	1981-06-05	1982-12-09	Fuji Photo Film Co Ltd	Mutilayer analysis element utilizing unique binding reaction
JPS5818167A (ja) *	1981-07-24	1983-02-02	Fuji Photo Film Co Ltd	分析フイルム及びこれを用いる分析方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4258001A (en) *	1978-12-27	1981-03-24	Eastman Kodak Company	Element, structure and method for the analysis or transport of liquids
US4390343A (en) *	1981-07-06	1983-06-28	Miles Laboratories, Inc.	Multilayer analytical element having an impermeable radiation diffusing and blocking layer

1984
- 1984-05-29 DE DE8484902316T patent/DE3482773D1/de not_active Expired - Fee Related
- 1984-05-29 AU AU30178/84A patent/AU576771B2/en not_active Ceased
- 1984-05-29 JP JP59502271A patent/JPS61501866A/ja active Granted
- 1984-05-29 AT AT84902316T patent/ATE54756T1/de not_active IP Right Cessation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS53131089A (en) *	1977-01-14	1978-11-15	Eastman Kodak Co	Element for analysis of liquid
JPS5767860A (en) *	1980-10-15	1982-04-24	Fuji Photo Film Co Ltd	Material for multilayer analysis
JPS57200862A (en) *	1981-06-05	1982-12-09	Fuji Photo Film Co Ltd	Mutilayer analysis element utilizing unique binding reaction
JPS5818167A (ja) *	1981-07-24	1983-02-02	Fuji Photo Film Co Ltd	分析フイルム及びこれを用いる分析方法

Also Published As

Publication number	Publication date
AU576771B2 (en)	1988-09-08
AU3017884A (en)	1985-12-31
DE3482773D1 (de)	1990-08-23
JPH0449911B2 (fr)	1992-08-12
ATE54756T1 (de)	1990-08-15

Publication	Publication Date	Title
EP0185654B1 (fr)	1990-07-18	Element multicouche pour analyse
EP0051183B1 (fr)	1987-08-26	Elément d'analyse à plusieurs couches
KR101066707B1 (ko)	2011-09-21	분석 장치의 동적 검출 범위의 확장 방법
EP0427984B2 (fr)	2000-12-27	Articles pour utilisation dans les techniques enzyme-immunoessais et méthodes pour fabriquer ces articles
JP4934147B2 (ja)	2012-05-16	迅速診断のためのテスト装置
US7943395B2 (en)	2011-05-17	Extension of the dynamic detection range of assay devices
US6689317B1 (en)	2004-02-10	Immunoassay apparatus for diagnosis
CN112513613B (zh)	2024-12-31	用于放大侧向流动测定信号的系统、装置和方法
WO1992004612A1 (fr)	1992-03-19	Microanalyse sur une carte
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WO1987007304A1 (fr)	1987-12-03	Procede et systeme de detection de cellules
WO1987003690A1 (fr)	1987-06-18	Immunoanalyse de composants de liaison lies a des particules
KR101057918B1 (ko)	2011-08-19	분석 장치에서 후크 효과의 감소
JP2012242162A (ja)	2012-12-10	標識用複合粒子
JP2001033454A (ja)	2001-02-09	多孔質固相リガンド測定試験片上における被検物質の定量法および装置
JPS63210664A (ja)	1988-09-01	酸素要求検出系を用いる装置のための乾燥試験片及び被検流体中の分析成分の検出方法
JPS61501866A (ja)	1986-08-28	分析用多層要素
JPH0424660B2 (fr)	1992-04-27
JPH01237455A (ja)	1989-09-21	乾式免疫分析要素
CA2149537A1 (fr)	1994-01-20	Methode servant a preparer des courbes d'etalonnage