JPS6169720A - Antiseptic composition - Google Patents

Abstract

PURPOSE:An antiseptic composition that is obtained by adding antiseptics to a base of oil free from water, thus developing its effect with lower concentration than the conventional compositions with reduced side-effects. CONSTITUTION:The objective antiseptic composition is obtained by adding antiseptic agents such as triiodomethane, phenol or cresol to an oil melting below 45 deg.C. As the oil, are cited olive oil, squallan, jujube oil or 2-ethylhexanoic acid. When water-free oil is used as a base, the dose can be reduced to 1/2-1/100 that of the conventional composition. Further, the addition of a silicone oil such as methylpolysiloxane, methylphenylpolysiloxane markedly increase its effect.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a disinfectant composition for external use, and more particularly to a disinfectant composition for external use.

An oil with a melting point of 45° C. or less was used as a base. The present invention relates to a disinfectant composition that exhibits an effective effect even when containing a disinfectant at a lower concentration than conventional disinfectant compositions.

[Conventional technology]

Conventionally, external disinfectant compositions include water/oil emulsions as soft pastes, oil/water emulsions as creams, and petrolatum ointments with petrolatum gold bases.

Gels and the like using water-soluble polymers as bases are used. [Problems to be solved by the invention] However, conventional disinfectant compositions using these bases do not contain chemicals at high concentrations. Despite the fact that it is blended, the actual effect was not satisfactory.

[Means for solving problems]

In view of this fact, we have conducted intensive research to provide a dosage form that is sufficiently effective even with low drug concentrations, and have found that using an oil that does not contain water as a base material is effective for this purpose. The present invention was completed by discovering that the following can be achieved, and that the effect can be significantly increased by blending silicone oil with it.

Accordingly, one object of the present invention is to provide a bactericidal composition containing a bactericidal agent in an oil having a melting point of 45° C. or less. Another object of the present invention is to provide a disinfectant composition further containing silicone oil.

In the present invention, examples of the bactericidal agent include triiodomethane, phenol, cresol, hexachlorophene, resorcinol, benzalkonium mide, sodium lauryl sulfate, and chlorhexidine gluconate.

Examples of the oil used as a base in the present invention include vegetable oil,
Examples include animal oils, synthetic oils, fatty acids and natural or synthetic fatty acid triglycerides.

Vegetable oils include olive oil, almond oil, jojoba oil, peanut oil, evening primrose oil, macadamia nut oil, castor oil, coconut oil, cacao butter, palm oil, palm kernel oil, safflower oil, sunflower oil, and safflower oil. Oils, hydrogenated coconut oil, hydrogenated palm oil, avocado oil, grapeseed oil, sesame oil, sasanquat oil, soybean oil.

camellia oil, corn oil, rapeseed oil, versic oil,
Examples include cottonseed oil, cassava, and carnauba wax. Animal oils include lanolin and lanolin derivatives, turdle oil, 1 guinea pig oil, and mink oil.

Beeswax, squalane, squalene, pristane.

Examples include beef tallow, hydrogenated oil, pig intestine, egg yolk oil, shellac, and beeswax. Examples of the synthetic oil include liquid paraffin, α-olefin oligomer, liquid polyimbutylene, pristane, vaseline, paraffin, and the like. As fatty acids, linear saturated fats such as hexanoic acid, heptanoic acid, octanoic acid, and nonane powder ff: 2-ethylhexanoic acid, isocaproic acid.

2-Methylundecanoic acid, 3-methyltocosanl! 2゜2.2-Methyldodecanoic acid, methyltetradecanoic acid, 2
-ethyltetradecanoic acid, 2-propyltridecanoic acid,
2-butyldodecanoic acid, 2-pentylundecanoic acid, 2
- Branched saturated fatty acids such as hebutylnonane, 2.3-dimethyltetradecanoic acid, 2-ethylhexadecanoic acid, 2-heptylundecanoic acid, 2-butyltetradecanoic acid, isostearic acid, emery type isostearin; 3-hexenoic acid, 4-hexenoic acid, 6-hebute7e, 3-octenoic acid % 2-decenoic acid, 4-decenoic acid, 9-undecenoic acid, 10-undecenoic acid, 3-dodecenic acid, cis-9
-tridecenoic acid, 4-tetrazoceph eR1V7. -9-
Hexadecene rI1. cis-7-hebutadenoic acid, cis-8-heptadenoic acid, cis-9-heptadenoic acid, cis-7-octadecenoic acid, cis-8-octadecenoic acid,
Linear monoenes such as cis-9-nonadecenoic acid and cis-11-eicosenoic acid [FF acid nidorans-2-methyl-2-
Pentenoic acid, cis-2-methyl-2-hexenoic acid, 2-
Branched monoenoic fatty acids such as methylenehexanoic acid, methacrylic acid, 2-ethylhexanoic acid, 3-methyl-2-nonene, 3-methyl-3-nonenoic acid, L (→-2.4-dimethyl-2-dodecenoic acid; Knorr Acid, trans-10.
Cis-12-octadecadienoic acid, cis-9, cis-1
di-, tri- or tetraenoic fatty acids such as 1-octadecadienoic acid, lylunic acid, arachidonic acid, and culpanodonic acid;
2-hexyne, 2-heptic acid, 2-octynic acid, 7
Examples include acetylene fatty acids such as -octynic acid, 2-nonynoic acid, 2-decyne R, 6-unzosic acid, 6-dodecyne W1.7-dobucic acid, 6-doridecinate, and 8-doridecinate. Also, as natural and synthetic fatty acid triglycerides.

For example, tributyrin (4,4,4),) licaproin (
6,6,6),) Licaprylin (8,8゜8), 1-caproyl-2,3-diolein (6゜18', 18'
), 1-elide-2,3-cicaglyrin (8,8,1
8'), 1-lyluo-2,3-dicaglyline (8,8,
18'), 1-cabriclue 2,3-diolein (8,
18', 18'), ) linnanin (9,9,9
),) Licaprin (10°10.10), 1-Lauro-
2,3-Cicaprin (10,10,12), I
-Mi II St-2,3-Cicaprine (10,10,14), 1-oleo-2,3-Cicaprine (10,10,18'), 1-elide-2,
3-Cicapurin (10,10,18').

1-Rilluo 2.3-Cicaprine (10, 10°18'
I), 2-oleo-1,3-cycaprine (10°18'
, 10), 1-Cabryl-2,3-diolein (10,
18', 18'), 1-Cabryl-2,3-dielaidine (10,18', 18'), 1-oleo-2,3-dilaurine (12,12,18'), 1-Elaidine-2
, 3-dilaurine (12,12゜18'), 1-lyluo-2,3-dilaurine (12゜12.18'), 2-oleo-1,3-dilaurine (12,18', 12), 1
-Lauro-2,3-diolein (12,18',18'
), 1-lauro-2゜3-silylyne (12,18',
18'), 1-oleo-2,3-cimiristin (14,
14, 18').

1-Riloo 2,3-cimiristin (14,14゜18
), 1-myrist-2,3-diolein (14°18
', 18'), 1-myristo-2,3-silylin (14,18', 18'), 1-palmito-2゜3
-diolein (16,18', 18'), 1-palmito-2,3-silylin (16,18', 18').

1-Stearo-2,3-diolein (18,18').

18'), 1-stearlff-2, 3-silylin (1
8, 18', 18'),) diolein (ts', is'
.

18'), trilyluin (18', 18', 1
8').

2-stearo-1,3-diolein (18', 18゜1
8'), etc.

Among these oils, olive oil, jojoba oil, camellia oil,
Squalane, α-olefin oligomer.

Particularly preferred are 2-ditylhexanoic acid, isostearic acid, 2-ethylhexanoic acid triglyceride, instearic acid triglyceride, and the like.

These oils, fatty acids, and fatty acid triglycerides can be used alone or as a mixture of two or more, and it is preferable that they have a melting point of 37° C. or lower.

The disinfectant composition of the present invention is composed of a disinfectant agent and an oil. It is prepared by simply mixing. The blend of bactericidal drugs varies depending on the class, but should be 1/1/2 of the amount of conventional external preparations.
2 to 1/100 i is sufficient.

It is usually blended in an amount of 0.01 to 0.0001% of the total composition.

Examples of the silicone oil used in the present invention include methylpolysiloxane, methylphenylpolysiloxane, dimethylpolysiloxane polyethylene glycol copolymer, dimethylpolysiloxane polyethylene glycol copolymer, cyclic dimethylsiloxane, dimethyltrimethylpolysiloxane, and amine. Examples include silicone, methylhydrodiene polysiloxane, and the like. It is preferable to mix these in an amount of 5 to 50% of the total composition.
In this case, the amount of bactericidal agent added is 1 of that of conventional external preparations.
/10~115oo.

The fungicidal composition of the present invention can be used for example in lotions, sprays, etc.
Water-free oil-based fungicidal compositions which can be in the form of skin drops are particularly preferred.

〔Effect of the invention〕

As mentioned above, the fungicide composition of the present invention can obtain sufficient effects in an amount of 1/2 to 1500 of the usual amount,
Furthermore, side effects of drugs can also be reduced.

〔Example〕

Next, the present invention will be described with reference to examples, but the present invention is not limited thereto.

Example 1 ■[Benzalkonium chloride 0.005 (1 part by weight)■
Squalane 20.0 ・■ Isostearic acid Balance meter 100 [F] ~ ■ Mix well to make a lotion.

Example 2 ■ GlucoΔmonchlorhexinone 0.01
(Part of Mi+) ■Jojoba oil 30.0 ■2-Ethyl hexaΔ triglyceride 45.0 ■Dimethylpolysiloxane (1cs) Balance meter 1
00 ■~■ are mixed well and filled into a pump spray container to make a spray type lawn yong. Does this invention cause itching in one area? When five women with the disease used it, the itching disappeared within 1 to 2 days.

Example 3 ■Hexachlorophene 0.01 (3FtJ)■
Olive oil 70.0 ■Dimethylpolysiloxane (1 cm) Balance meter 100 Mix ■~■ well and fill it into a spray container.

Surgical site 1 Used to disinfect wounds on fingers.

that's all

Claims (1)

[Scope of Claims] 1. A disinfectant composition characterized by containing a disinfectant in an oil having a melting point of 45°C or less. 2. A disinfectant composition comprising a disinfectant and a silicone oil contained in an oil having a melting point of 45°C or less.