JPS62158209A - 液状ユビキノン薬剤組成物 - Google Patents

液状ユビキノン薬剤組成物

Info

Publication number: JPS62158209A
Authority: JP; Japan
Prior art keywords: coenzyme; ubiquinone; active ingredient; composition according; cremophor
Prior art date: 1985-12-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP61307593A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0455404B2 (fr

Inventor

ピエール　ノエル　ブラゼー

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ZOIREFU AG

Original Assignee

ZOIREFU AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-24

Filing date

1986-12-23

Publication date

1987-07-14

1986-12-23 Application filed by ZOIREFU AG filed Critical ZOIREFU AG

1987-07-14 Publication of JPS62158209A publication Critical patent/JPS62158209A/ja

1992-09-03 Publication of JPH0455404B2 publication Critical patent/JPH0455404B2/ja

Status Granted legal-status Critical Current

Links

235000017471 coenzyme Q10 Nutrition 0.000 title claims description 30
ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims description 29
239000000203 mixture Substances 0.000 title claims description 24
ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims description 10
NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 title claims description 8
229940035936 ubiquinone Drugs 0.000 title claims description 8
239000007788 liquid Substances 0.000 title claims 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 14
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 14
239000008389 polyethoxylated castor oil Substances 0.000 claims description 14
239000004480 active ingredient Substances 0.000 claims description 12
WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims description 12
CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims description 8
239000002904 solvent Substances 0.000 claims description 8
229930003427 Vitamin E Natural products 0.000 claims description 7
239000003963 antioxidant agent Substances 0.000 claims description 7
235000006708 antioxidants Nutrition 0.000 claims description 7
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
235000019165 vitamin E Nutrition 0.000 claims description 7
229940046009 vitamin E Drugs 0.000 claims description 7
239000011709 vitamin E Substances 0.000 claims description 7
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
229940079877 pyrogallol Drugs 0.000 claims description 6
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims description 4
QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical group C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 claims description 4
229920000151 polyglycol Polymers 0.000 claims description 4
239000010695 polyglycol Substances 0.000 claims description 4
239000000600 sorbitol Substances 0.000 claims description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
235000014113 dietary fatty acids Nutrition 0.000 claims description 3
229930195729 fatty acid Natural products 0.000 claims description 3
239000000194 fatty acid Substances 0.000 claims description 3
150000004665 fatty acids Chemical class 0.000 claims description 3
239000012875 nonionic emulsifier Substances 0.000 claims description 3
239000002736 nonionic surfactant Substances 0.000 claims description 3
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
235000010323 ascorbic acid Nutrition 0.000 claims description 2
239000011668 ascorbic acid Substances 0.000 claims description 2
229960005070 ascorbic acid Drugs 0.000 claims description 2
238000009833 condensation Methods 0.000 claims description 2
230000005494 condensation Effects 0.000 claims description 2
235000011187 glycerol Nutrition 0.000 claims description 2
239000003921 oil Substances 0.000 claims description 2
239000008194 pharmaceutical composition Substances 0.000 claims description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
125000003158 alcohol group Chemical group 0.000 claims 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
230000000640 hydroxylating effect Effects 0.000 claims 1
229920000642 polymer Polymers 0.000 claims 1
238000011200 topical administration Methods 0.000 claims 1
125000001655 ubiquinone group Chemical group 0.000 claims 1
239000005515 coenzyme Substances 0.000 description 10
238000010521 absorption reaction Methods 0.000 description 7
239000000243 solution Substances 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
230000001225 therapeutic effect Effects 0.000 description 4
241000700159 Rattus Species 0.000 description 3
230000003078 antioxidant effect Effects 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
238000000034 method Methods 0.000 description 3
238000007911 parenteral administration Methods 0.000 description 3
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
244000309464 bull Species 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
230000007170 pathology Effects 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
230000002110 toxicologic effect Effects 0.000 description 2
231100000027 toxicology Toxicity 0.000 description 2
229930003231 vitamin Natural products 0.000 description 2
239000011782 vitamin Substances 0.000 description 2
235000013343 vitamin Nutrition 0.000 description 2
229940088594 vitamin Drugs 0.000 description 2
150000003722 vitamin derivatives Chemical class 0.000 description 2
XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 description 1
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
230000002407 ATP formation Effects 0.000 description 1
241000700198 Cavia Species 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
206010061216 Infarction Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
206010028372 Muscular weakness Diseases 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000008135 aqueous vehicle Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229940110767 coenzyme Q10 Drugs 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
239000000645 desinfectant Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
-1 glucosades Chemical class 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
230000000749 insecticidal effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
230000002438 mitochondrial effect Effects 0.000 description 1
230000036473 myasthenia Effects 0.000 description 1
230000002107 myocardial effect Effects 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000027756 respiratory electron transport chain Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000011282 treatment Methods 0.000 description 1
229960004747 ubidecarenone Drugs 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oil, Petroleum & Natural Gas (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

JP61307593A 1985-12-24 1986-12-23 液状ユビキノン薬剤組成物 Granted JPS62158209A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH5525/85-2		1985-12-24
CH5525/85A CH667387A5 (it)	1985-12-24	1985-12-24	Formulazioni farmaceutiche acquose di ubichinone.

Publications (2)

Publication Number	Publication Date
JPS62158209A true JPS62158209A (ja)	1987-07-14
JPH0455404B2 JPH0455404B2 (fr)	1992-09-03

Family

ID=4295081

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP61307593A Granted JPS62158209A (ja)	1985-12-24	1986-12-23	液状ユビキノン薬剤組成物

Country Status (7)

Country	Link
JP (1)	JPS62158209A (fr)
BE (1)	BE906034A (fr)
CH (1)	CH667387A5 (fr)
DE (1)	DE3643330A1 (fr)
FR (1)	FR2598320B1 (fr)
GB (1)	GB2184355B (fr)
IT (1)	IT1198247B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005035477A1 (fr) *	2003-10-08	2005-04-21	Kaneka Corporation	Procede pour stabiliser un compose presentant un squelette quinone et composition ainsi stabilisee
JP2008520563A (ja) *	2004-11-16	2008-06-19	バイオアバイラビリティ，インク．	栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物
JP2013064009A (ja) *	2012-12-07	2013-04-11	Bioavailability Inc	栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物
JP2013107889A (ja) *	2012-12-07	2013-06-06	Bioavailability Inc	栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1250672B (it) *	1991-07-11	1995-04-21	Idb Holding Spa	Formulazioni orali di ubidecarenone in soluzione acquosa
ES2051643B1 (es) *	1992-10-13	1995-02-16	Inverni Della Beffa Farma	Formulaciones orales de ubidecarenona en forma de soluciones acuosas.
GR1001364B (el) *	1992-10-16	1993-10-29	Inverni Della Beffa Farma	Από του στόματος συν?έσεις ουβιδεκαρενόνης υπό μορφήν υδατικών διαλυμάτων.
WO1998035658A2 (fr) *	1997-02-12	1998-08-20	Mse Pharmazeutika Gmbh	Utilisation de 2,3-dimethoxy-5-methyle-6-decaprenyle-1,4-benzoquinone
ES2268246T3 (es) *	1997-02-12	2007-03-16	Mse Pharmazeutika Gmbh	Uso de 2,3-dimetoxi-5-metil-6-decaprenil-1,4-benzoquinona en el tratamiento de incontinencia.
US5925335A (en) *	1997-06-12	1999-07-20	C.S. Bioscience Inc.	Dental formulation
EP0888774A3 (fr) *	1997-06-30	1999-11-10	Soft Gel Technologies, Inc.	Formulation de gel contenant la coenzyme Q10
US6200550B1 (en) *	1998-12-11	2001-03-13	Q-Pharma, Inc.	Oral care compositions comprising coenzyme Q10
DE19944137A1 (de) *	1999-09-15	2001-03-22	Beiersdorf Ag	O/W-Emulsionen mit einem Gehalt an einem oder mehreren Biochinonen und einem erhöhten Gehalt an Glycerin
CA2441940A1 (fr) *	2001-03-27	2002-10-03	C.S. Bioscience, Inc.	Preparation dentaire
JP3742602B2 (ja) *	2001-05-09	2006-02-08	株式会社カネカ	還元型補酵素ｑの安定な溶液

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5218811A (en) *	1975-08-01	1977-02-12	Eisai Co Ltd	Preparation of aqueous solution of fat- soluble substances

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1334961A (fr) *	1961-03-06	1963-08-16	Merck & Co Inc	Solutions aqueuses stables à base de benzoquinone substituée
NL275602A (fr) *	1961-03-06
JPS498246B1 (fr) *	1965-07-15	1974-02-25
GB1225979A (fr) *	1967-03-23	1971-03-24
GB1317865A (en) *	1971-11-15	1973-05-23	Jujo Paper Co Ltd	Biologically active composition
JPS58113127A (ja) *	1981-12-28	1983-07-05	Ajinomoto Co Inc	ユビデカレノン含有水性液
JPS6025918A (ja) *	1983-07-25	1985-02-08	Ajinomoto Co Inc	脂溶性薬物含有水性液

1985
- 1985-12-24 CH CH5525/85A patent/CH667387A5/it not_active IP Right Cessation
1986
- 1986-12-17 GB GB8630158A patent/GB2184355B/en not_active Expired - Fee Related
- 1986-12-18 DE DE19863643330 patent/DE3643330A1/de not_active Ceased
- 1986-12-23 BE BE0/217600A patent/BE906034A/fr not_active IP Right Cessation
- 1986-12-23 FR FR868618075A patent/FR2598320B1/fr not_active Expired - Fee Related
- 1986-12-23 JP JP61307593A patent/JPS62158209A/ja active Granted
- 1986-12-23 IT IT22844/86A patent/IT1198247B/it active

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5218811A (en) *	1975-08-01	1977-02-12	Eisai Co Ltd	Preparation of aqueous solution of fat- soluble substances

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005035477A1 (fr) *	2003-10-08	2005-04-21	Kaneka Corporation	Procede pour stabiliser un compose presentant un squelette quinone et composition ainsi stabilisee
JP2008520563A (ja) *	2004-11-16	2008-06-19	バイオアバイラビリティ，インク．	栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物
JP2013064009A (ja) *	2012-12-07	2013-04-11	Bioavailability Inc	栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物
JP2013107889A (ja) *	2012-12-07	2013-06-06	Bioavailability Inc	栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物

Also Published As

Publication number	Publication date
IT1198247B (it)	1988-12-21
GB2184355B (en)	1990-03-28
IT8622844A1 (it)	1988-06-23
IT8622844A0 (it)	1986-12-23
FR2598320B1 (fr)	1990-11-02
BE906034A (fr)	1987-04-16
FR2598320A1 (fr)	1987-11-13
GB2184355A (en)	1987-06-24
JPH0455404B2 (fr)	1992-09-03
DE3643330A1 (de)	1987-06-25
GB8630158D0 (en)	1987-01-28
CH667387A5 (it)	1988-10-14

Publication	Publication Date	Title
JPS62158209A (ja)	1987-07-14	液状ユビキノン薬剤組成物
CN102470176B (zh)	2015-07-29	药物制剂
JP4086501B2 (ja)	2008-05-14	シリビンを含有する経口用マイクロエマルジョン組成物
JP2662183B2 (ja)	1997-10-08	サイクロスポリン軟質カプセル剤組成物
JPH02235817A (ja)	1990-09-18	新規シクロスポリン製剤
JP2002534382A (ja)	2002-10-15	タキサン類の薬学的調合物
JPH11506463A (ja)	1999-06-08	親脂性に富んだカンプトテシン誘導体治療薬
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JP2002513750A (ja)	2002-05-14	溶媒／助溶剤を含まないマイクロエマルジョン及びエマルジョンプレ濃縮物のドラッグデリバリーシステム
ES2285196T3 (es)	2007-11-16	Composciones farmaceuticas que comprenden ciclosporina, un ester de propilenglicol y un tensoactivo no ionico.
FI94837C (fi)	1995-11-10	Vesiliukoisia monoestereitä käytettäväksi farmakologisesti aktiivisten yhdisteiden kantajana ja farmaseuttisten apuaineiden liukoisuutta lisäävinä aineina
JP2855135B2 (ja)	1999-02-10	サイクロスポリン含有軟質カプセル剤組成物
JP2005539003A (ja)	2005-12-22	経口投与用シクロスポリン含有医薬組成物
JP3519414B2 (ja)	2004-04-12	サイクロポリン含有軟質カプセル製剤
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JP2005539002A (ja)	2005-12-22	シクロスポリン含有経口医薬組成物
JPS63192714A (ja)	1988-08-10	非経口用溶液
JP3276762B2 (ja)	2002-04-22	イソキノリン誘導体を含有する医薬組成物
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JPS62158209A - 液状ユビキノン薬剤組成物 - Google Patents

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